Patient-specific surrogate model to predict pelvic floor dynamics during vaginal delivery.

Childbirth is a challenging event that can lead to long-term consequences such as prolapse or incontinence. While computational models are widely used to mimic vaginal delivery, their integration into clinical practice is hindered by time constraints. The primary goal of this study is to introduce an artificial intelligence pipeline that leverages patient-specific surrogate modeling to predict pelvic floor injuries during vaginal delivery.

Pregnancy state before the onset of labor: a holistic mechanical perspective.

Successful pregnancy highly depends on the complex interaction between the uterine body, cervix, and fetal membrane. This interaction is synchronized, usually following a specific sequence in normal vaginal deliveries: (1) cervical ripening, (2) uterine contractions, and (3) rupture of fetal membrane. The complex interaction between the cervix, fetal membrane, and uterine contractions before the onset of labor is investigated using a complete third-trimester gravid model of the uterus, cervix, fetal membrane, and abdomen.

Development of a multilayer fetal membrane material model calibrated using bulge inflation mechanical tests.

The fetal membranes are an essential mechanical structure for pregnancy, protecting the developing fetus in an amniotic fluid environment and rupturing before birth. In cooperation with the cervix and the uterus, the fetal membranes support the mechanical loads of pregnancy. Structurally, the fetal membranes comprise two main layers: the amnion and the chorion.

Injuries in Muscle-Tendon-Bone Units: A Systematic Review Considering the Role of Passive Tissue Fatigue.

Background: Low-cycle fatigue damage accumulating to the point of structural failure has been recently reported at the origin of the human anterior cruciate ligament under strenuous repetitive loading. If this can occur in a ligament, low-cycle fatigue damage may also occur in the connective tissue of muscle-tendon units. To this end, we reviewed what is known about how, when, and where injuries of muscle-tendon units occur throughout the body.

A 3D trabecular bone homogenization technique.

Purpose: Bone is a hierarchical material that can be characterized from the microscale to macroscale. Multiscale models make it possible to study bone remodeling, inducing bone adaptation by using information of bone multiple scales. This work proposes a computationally efficient homogenization methodology useful for multiscale analysis.

The management of episiotomy technique and its effect on pelvic floor muscles during a malposition childbirth.

Vaginal childbirth is the leading cause of pelvic floor muscles injury, which contributes to pelvic floor dysfunction, being enhanced by fetal malposition. Therefore, the aim of the present study is to verify the influence of mediolateral episiotomies in the mechanics of the pelvic floor with the fetus in occiput posterior position when compared to the occiput anterior position. Numerical simulations of vaginal deliveries, with and without episiotomy, are performed based on the Finite Element Method.

A biomechanical analysis on the impact of episiotomy during childbirth.

Episiotomy is still a controversy issue among physicians, despite the enormous growth of clinical research. Therefore, the potential of numerical modeling of anatomical structures to simulate biomechanical processes was exploited to realize quantitatively the real effects of the episiotomy and its consequences on the pelvic floor muscle. As such, a numerical model was used composed of pelvic floor muscles, a surface delimiting the anterior region, and a fetus body.

Segmentation of female pelvic organs in axial magnetic resonance images using coupled geometric deformable models.

The segmentation of pelvic structures in magnetic resonance (MR) images of the female pelvic cavity is a challenging task. This paper proposes the use of three novel geometric deformable models to segment the bladder, vagina and rectum in axial MR images. The different imaging appearances and prior shape knowledge are combined into a level set framework as segmentation cues.

Strength of round and uterosacral ligaments: a biomechanical study.

Purpose: To investigate the tensile biomechanical properties of round and uterosacral ligaments.

Methods: Tissue samples were obtained from 15 female cadavers without pelvic organ prolapse. Uniaxial tensile tests were performed to obtain stiffness and maximum stress of round and uterosacral ligaments.

A meshless microscale bone tissue trabecular remodelling analysis considering a new anisotropic bone tissue material law.

In this work, a novel anisotropic material law for the mechanical behaviour of the bone tissue is proposed. This new law, based on experimental data, permits to correlate the bone apparent density with the obtained level of stress. Combined with the proposed material law, a biomechanical model for predicting bone density distribution was developed, based on the assumption that the bone structure is a gradually self-optimising anisotropic biological material that maximises its own structural stiffness.

Uniaxial mechanical behavior of the human female bladder.

Introduction And Hypothesis: The objective of the present study was to investigate the tensile biomechanical properties of the human female bladder.

Methods: Tissue samples were obtained from 13 cadavers without pelvic floor dysfunctions. We performed uniaxial tensile tests to measure the stiffness and maximum stress of the bladder tissue.

Vaginal tissue properties versus increased intra-abdominal pressure: a preliminary biomechanical study.

Background/aims: This study aims to evaluate the pelvic floor (PF) tension response during simulated increased intra-abdominal pressure (IAP) and the vaginal biomechanical properties.

Methods: A 3-dimensional computational finite element model for PF was developed based on magnetic resonance imaging from a nulliparous healthy volunteer. The model was used to simulate an IAP of 90 cm H(2)O and to evaluate the PF stresses in the longitudinal and transversal axes.

Structural and thermal properties of polypropylene mesh used in treatment of stress urinary incontinence.

Besides material biocompatibility, it is possible to infer that both vaginal and urethral erosion rates associated with sub-urethral synthetic slings may be related to the mechanical properties of the meshes and also to their other properties. With the aim of understanding what distinguishes the different polypropylene meshes, used for the treatment of the stress urinary incontinence (SUI), their structural and thermal properties were investigated. Five different mesh types were tested (Aris, Auto Suture, Avaulta, TVTO and Uretex).