Influence of upper blepharoplasty on intraocular lens calculation.

Purpose: To determine the effect of upper blepharoplasty on corneal topography and intraocular lens power calculation using Galilei and IOLMaster.

Methods: Thirty patients submitted to upper blepharoplasty from May 2014 to March 2017 at the Hospital Oftalmológico de Sorocaba (São Paulo, Brazil) were included in this observational case series. All patients underwent imaging sessions with Galilei and IOLMaster preoperatively (baseline) and at 1 and 6 months postoperatively.

Automated algorithms combining structure and function outperform general ophthalmologists in diagnosing glaucoma.

Purpose: To test the ability of machine learning classifiers (MLCs) using optical coherence tomography (OCT) and standard automated perimetry (SAP) parameters to discriminate between healthy and glaucomatous individuals, and to compare it to the diagnostic ability of the combined structure-function index (CSFI), general ophthalmologists and glaucoma specialists.

Design: Cross-sectional prospective study.

Methods: Fifty eight eyes of 58 patients with early to moderate glaucoma (median value of the mean deviation = -3.

Use of statistical analyses in the ophthalmic literature.

Purpose: To identify the most commonly used statistical analyses in the ophthalmic literature and to determine the likely gain in comprehension of the literature that readers could expect if they were to add knowledge of more advanced techniques sequentially to their statistical repertoire.

Design: Cross-sectional study.

Methods: All articles published from January 2012 through December 2012 in Ophthalmology, the American Journal of Ophthalmology, and Archives of Ophthalmology were reviewed.

Prevalence and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus in ocular infections.

Purpose: To study the prevalence of methicillin-resistant Staphylococcus aureus among S. aureus ocular infections in a tertiary health center in Brazil and compare antibiotic susceptibility patterns between MRSA and methicillin-susceptible S. aureus isolates.

Predicting progression of glaucoma from rates of frequency doubling technology perimetry change.

Purpose: To evaluate the ability of longitudinal frequency doubling technology (FDT) to predict the development of glaucomatous visual field loss on standard automated perimetry (SAP) in glaucoma suspects.

Design: Prospective, observational cohort study.

Participants: The study included 587 eyes of 367 patients with suspected glaucoma at baseline selected from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES).

Likelihood ratios for glaucoma diagnosis using spectral-domain optical coherence tomography.

Purpose: To present a methodology for calculating likelihood ratios for glaucoma diagnosis for continuous retinal nerve fiber layer (RNFL) thickness measurements from spectral-domain optical coherence tomography (spectral-domain OCT).

Design: Observational cohort study.

Methods: A total of 262 eyes of 187 patients with glaucoma and 190 eyes of 100 control subjects were included in the study.

Evaluation of progressive neuroretinal rim loss as a surrogate end point for development of visual field loss in glaucoma.

Purpose: To evaluate the validity of using progressive loss of neuroretinal rim area as a surrogate end point for the development of visual field loss in glaucoma.

Design: Prospective, observational cohort study.

Participants: The study group included 492 eyes of 328 patients classified with suspected glaucoma at the baseline visit.

Advances in the Structural Evaluation of Glaucoma with Optical Coherence Tomography.

Optical coherence tomography (OCT) is capable of providing quantitative and objective assessments of the optic disc, macula and retinal nerve fiber layer in glaucoma. The recent advent of spectral domain OCT (SD-OCT) has enhanced the resolution, decreased scan acquisition time, and improved the reproducibility of measurements compared to older versions of this technology. However, although OCT has been successfully used for detection of disease and evaluation of progression, the limited agreement between structural and functional tests indicates the strong need for a combined approach for detecting and monitoring the disease.

Predicting progression in glaucoma suspects with longitudinal estimates of retinal ganglion cell counts.

Purpose: We evaluated the ability of baseline and longitudinal estimates of retinal ganglion cell (RGC) counts in predicting progression in eyes suspected of having glaucoma.

Methods: The study included 288 glaucoma suspect eyes of 288 patients followed for an average of 3.8 ± 1.

Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study.

Purpose: To evaluate the role of corneal hysteresis (CH) as a risk factor for the rate of visual field progression in a cohort of patients with glaucoma followed prospectively over time.

Design: Prospective observational cohort study.

Participants: The study group included 114 eyes of 68 patients with glaucoma followed for an average of 4.

Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.

Purpose: To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage.

Methods: The study included 142 eyes from 91 patients suspected of having the disease based on the appearance of the optic disc. All eyes had normal visual fields before the imaging session.

Association between rates of binocular visual field loss and vision-related quality of life in patients with glaucoma.

Importance: It is reasonable to hypothesize that for 2 patients with similar degrees of integrated binocular visual field (BVF) loss, the patient with a history of faster disease progression will report worse vision-related quality of life (VRQOL) than the patient with slowly progressing damage. However, to our knowledge, this hypothesis has not been investigated in the literature.

Objective: To evaluate the association between binocular rates of visual field change and VRQOL in patients with glaucoma.

Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma.

Purpose: To estimate retinal ganglion cell (RGC) losses associated with the earliest development of visual field defects in glaucoma.

Design: Observational cohort study.

Participants: The study group included 53 eyes of 53 patients with suspected glaucoma who were followed as part of the Diagnostic Innovations in Glaucoma (DIGS) study.

Combining structure and function to evaluate glaucomatous progression: implications for the design of clinical trials.

The selection of a suitable method for assessment of glaucomatous progression and estimation of rates of change is an essential component of the design of clinical trials investigating neuroprotective therapies for the disease. Due to the limitations of currently available tests, approaches combining structural and functional tests are essential in order to provide reliable detection of endpoints. This could also potentially enable shorter clinical trials with relatively smaller sample size requirements.

A combined index of structure and function for staging glaucomatous damage.

Objectives: To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage.

Methods: Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects. All the eyes were tested with standard automated perimetry and spectral domain optical coherence tomography within 6 months.

Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography.

Purpose: To evaluate the diagnostic accuracy of spectral domain optical coherence tomography (SD-OCT) for detection of preperimetric glaucoma and compare it with the performance of confocal scanning laser ophthalmoscopy (CSLO).

Design: Cohort study.

Participants: A cohort of 134 eyes of 88 glaucoma suspects based on the appearance of the optic disc.

A combined index of structure and function for staging glaucomatous damage.

Objectives: To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage.

Methods: Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects.All the eyes were tested with standard automated perimetry and spectral domain optical coherence tomography within 6 months.

Incorporating risk factors to improve the assessment of rates of glaucomatous progression.

Purpose: To present and evaluate a new method of integrating risk factors into the analysis of rates of visual field progression in glaucoma.

Methods: The study included 352 eyes of 250 glaucoma patients followed up for an average of 8.1 ± 3.

Immunoblotting for the serodiagnosis of Helicobacter pylori infection in Brazilian patients with and without gastric carcinoma.

We evaluated the performance of a commercial immunoblotting in the serodiagnosis of Helicobacter pylori infection in Brazilian patients. The presence of anti-H. pylori antibodies was also investigated in a group of 20 duodenal ulcer patients after successful treatment.