Microfluidic extensional flow device to study mass transfer dynamics in the polymer microparticle formation process.

Polymer microparticles are often used to encapsulate drugs for sustained drug-release treatments. One of the ways they are manufactured is by using a solvent extraction process, in which the polymer solution is emulsified into an aqueous bulk phase using a surfactant as a stabilizing agent, followed by the removal of the solvent. The radius of a polymer drop decreases as a function of time until the polymer reaches the gelling point, after which it is separated and dried.

A novel oxazolidinone antibiotic: RWJ-416457.

The crystal structure of the antibiotic drug candidate RWJ-416457 (systematic name: N-{(5S)-3-[4-(5,6-dihydro-2H,4H-2-methylpyrrolo[3,4-c]pyrazol-5-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}acetamide), C(18)H(20)FN(5)O(3), which belongs to the first new class of antibiotics discovered in the past 30 years, has been determined at 150 K. Each molecule of this drug donates one hydrogen bond to a neighboring molecule and accepts one hydrogen bond to give (O=C-R-N-H..

Applications of NIR in early stage formulation development. Part II. Content uniformity evaluation of low dose tablets by principal component analysis.

A near infrared method based on principal component analysis (PCA) was developed for predicting content uniformity of low dose tablets manufactured by a direct compression process. The work was conducted in early stage formulation development. NIR spectra of one hundred and eighty tablets from three feasibility batches were used as the pseudo-calibration set.

The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms.

This contribution concerns the issue of crystal nucleation in the polymorphic and hydrate forming system inosine-water. A combination of computational and experimental tools have been used to explore the relationship between solution phase inosine species and the structural synthons as found in its crystal structures. It is evident that the initial nucleation of a metastable polymorph at temperatures above 10 degrees C is directed by dimeric self-association as revealed through proton NMR.