DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.

Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug discovery. So far only a few ligases have been utilized for TPD.

Humidity sensors based on molecular rectifiers.

Ambient humidity plays a key role in the health and well-being of us and our surroundings, making it necessary to carefully monitor and control it. To achieve this goal, several types of instruments based on various materials and operating principles have been developed. Reducing the production costs for such systems without affecting their sensitivity and reliability would allow for broader use and greater efficiency.

The location independence of learned attentional flexibility.

Individuals can adjust their shift readiness, known as attentional flexibility, according to the statistical structure of the environment. However, the extent to which these modulations in attentional flexibility are associated with a global readiness to shift attention to any location versus an anticipated shift to a single location remains unknown. Across two experiments, participants shifted attention among three rapid serial visual presentation (RSVP) streams of alphanumeric characters in response to embedded visual cues and made button presses in response to targets at the cued location.