Dermatologic events from EGFR inhibitors: the issue of the missing patient voice.

Purpose: As epidermal growth factor receptor (EGFR) inhibitors are associated with a variety of dermatologic adverse events (dAEs), the purpose of this study was to develop an overview of current knowledge of dAEs associated with EGFR inhibitors and to identify knowledge gaps regarding incidence, treatment, impact on quality of life (QOL), and patient acceptance.

Method: A structured literature search was conducted using MEDLINE/PubMed (January 1983 to January 2014). In total, 71 publications published from 2004 to 2014 were identified for consideration in the final evidence review.

Water flows of MSW landfills and implications for long-term emissions.

A test landfill served for experiments to describe the water and material household of municipal solid waste (MSW) landfills. Special emphasis was given to the determination of the influence of the water flow on the substance balance. Therefore, a water balance was measured and the discharge was modeled by means of a mathematical model.