Publications by authors named "Renata Turek-Jabrocka"
Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total.
View Article and Find Full Text PDFAltered N-glycan profile of IgG-depleted serum proteins in Hashimoto's thyroiditis.
Biochim Biophys Acta Gen Subj
March 2020
Article Synopsis
- Hashimoto's thyroiditis (HT) is an autoimmune disorder that primarily causes inflammation of the thyroid gland and is the leading cause of hypothyroidism, though its exact mechanisms remain unclear.* -
- The study used high-performance liquid chromatography and mass spectrometry to analyze serum N-glycans in HT patients, revealing changes in glycosylation patterns, particularly an increase in specific sialylated structures and a decrease in core fucosylation.* -
- These glycosylation alterations may be linked to the chronic inflammation associated with HT, indicating that serum protein sialylation changes are characteristic of autoimmune processes in this condition.*
Article Synopsis
- Aggressive pituitary tumors causing Cushing's Disease are rare and often resistant to standard treatments; temozolomide (TZM) has emerged as a promising first-line chemotherapy for these cases.
- This report discusses a 61-year-old male who faced multiple surgeries and treatments for an invasive pituitary macroadenoma related to Cushing's Disease, showing initial improvement with TZM but eventually experiencing severe clinical deterioration.
- After nine cycles of TZM, the patient's tumor exhibited significant growth and associated clinical symptoms, ultimately leading to his death in February 2016.
Rationale: Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insufficiency following traumatic thoracic injury in adolescence.
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