Effects of glutathione supplementation during peritoneal dialysis.

We examined the effect of L-2-oxothiazolidine-4-carboxylate (OTZ) on peritoneal morphology and function of mesothelial cells in rats during peritoneal dialysis (PD). We implanted intraperitoneal catheters into 14 rats and injected the rats twice daily for 4 weeks with standard PD fluid (group C, control; n = 7) or PD fluid supplemented with OTZ 1 mmol/L (group OTZ; n = 7). At the beginning and the end of the study, we collected samples of 4-hour dwell effluents from every rat under sterile conditions.

Can an increased level of circulating IL-8 be a predictor of human longevity?

Background: Interleukin-6 (IL-6) and IL-8 are considered to be potent inflammatory agents. However, IL-8 has also been reported to serve as an organ protective factor. The goal of our study was to compare the circulating levels of IL-8 and IL-6 in C-reactive protein (CRP)-negative subjects of different ages.

[Morphology of neutrophils in centarians].

Recently, centenarians are involved in many research programs as they are believed to represent so-called successful aging. The aim of the study was to characterize morphological alterations observed in neutrophils from their peripheral blood. The study involved 40 centenarians (group B--34 females and 6 males) as well as 40 young healthy subjects aged 20-30 years (group K--35 females and 5 males).

Glucose suppresses peritoneal inflammatory reactions and mesothelial hyperplasia caused by intraperitoneal saline infusion.

In the past, we had observed that infusion of normal saline into the peritoneal cavity stimulates an inflammatory response. In the present study, we examined what effect the addition of glucose to normal saline would have on the peritoneal inflammatory response and change in peritoneal morphology. After catheter implantation, rats were infused intraperitoneally (i.

[Plasma level of interleukin-6 and interleukin-8 in the elderly].

It is believed that changes in the serum level of cytokines (e.g. IL-6) are natural consequence of physiological aging.