Differential expression of apoptosis-related genes from death receptor pathway in chronic myeloproliferative diseases.

Background: Chronic myeloproliferative disorders (MPDs) are clonal haematopoietic stem cell malignancies characterised by an accumulation of mature myeloid cells in bone marrow and peripheral blood. Deregulation of the apoptotic machinery may be associated with MPD physiopathology.

Aims: To evaluate expression of death receptors' family members, mononuclear cell apoptosis resistance, and JAK2 allele burden.