[Significance of tumor necrosis factor (TNF-alpha) in rheumatoid arthritis].

Tumor necrosis factor (TNF alpha) plays a key role in the pathogenesis of rheumatoid arthritis (RA), where both cell-mediated and humoral immune responses contribute to the destruction of cartilage and inflammation of synovium. This article presents genetics, properties and mechanisms of action of TNF alpha in RA. In addition, results of experimental and clinical studies are summarized, showing that treatment with antagonists against TNF alpha proved to be beneficial to the patients with RA by modifying the course of disease, slowing its progress and reducing its symptoms.