Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A: activation of endogenous phospholipases contributes to the pronociceptive effect.

Background: Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient's lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acute arthritis, using a Lys49-PLA ( myotoxin II; MT-II) to induce articular inflammation.