Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A: activation of endogenous phospholipases contributes to the pronociceptive effect.

Background: Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient's lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acute arthritis, using a Lys49-PLA ( myotoxin II; MT-II) to induce articular inflammation.

The effect of hetero- and homosexual experience and long-term treatment with fluoxetine on homosexual behavior in male rats.

Introduction: The selective serotonin reuptake inhibitors have become the most frequently prescribed drugs for the treatment of depression. Sexual side effects have been noted to occur with this treatment on heterosexual behavior in rats. Heterosexual experience facilitates sexual orientation of male rats and decreases the latencies to first mount and first intromission.