β-amyloid pathology is not associated with depression in a large community sample autopsy study.

Background: Depression has been associated with dementia. This study aimed to verify if β-amyloid Alzheimer's disease-type burden was associated with lifetime major depressive disorder (MDD) and with current depressive symptoms in a large population-based autopsy study.

Methods: We included 1013 deceased subjects submitted to autopsy (mean age=74.