Citral relaxes umbilical vessels of normotensive and preeclamptic parturients.

Introduction: Citral is a low-toxicity monoterpene that has a vasodilator effect on various smooth muscles, and The present study aimed to evaluate its vasorelaxant effect on umbilical vessels of normotensive parturients (NTP) and with preeclampsia parturients (PEP).

Method: Segments of human umbilical artery (HUA) and vein (HUV) of NTP or PEP were mounted in a bath to record the force of contraction, under tension of 3.0 gf and contracted with the contracting agents: K (60 mM), 5 -HT (10 μM) and Ba (1-30 mM).

Perillyl Alcohol Promotes Relaxation in Human Umbilical Artery.

Background: Perillyl alcohol (POH) is a monoterpenoid found in plant essential oils and has been shown to relax murine vessels, but its effect on human vessels remains poorly studied.

Objective: The study aimed to characterize the effect of POH on human umbilical arteries (HUA).

Methods: Rings of HUA were obtained from uncomplicated patients and suspended in an organ bath for isometric recording.

Pharmacological Screening of Species from the Lippia genus, Content in Terpenes and Phenylpropanoids, and their Vasorelaxing Effects on Human Umbilical Artery.

Background: Naturally occurring bioactive compounds have a plethora of biological effects.

Objective: In this study, we examined a pharmacological screening of natural products on the human umbilical artery (HUA).

Methods: HUA preparations were used to follow contractions by KCl (60 mM) and tested at different concentrations (1-5000 μg/mL and μM) of the Lippia alba (EOLa) and Lippia origanoides (EOLo) essential oils, terpenes (citral, limonene perilic alcohol) and phenylpropanoids (eugenol, methyl eugenol).

Effect of (Mill.) N.E. Brown Essential Oil on the Human Umbilical Artery.

is popularly known as lemon balm, with its essential oil (EO) cited for displaying antimicrobial, sedative, and vasorelaxant effects. Yet, its action on isolated human vessels has not been described in the literature. Thus, we evaluated the vasorelaxant effect of essential oil of (EOLa) on human umbilical arteries (HUA) isolated in organ baths.

Myorelaxant Effect of the Essential Oil on Coronary Artery and Its Toxicity in the Model.

Purpose: Alternative methods for the use of animals in research have gained increasing importance, due to assessments evaluating the real need for their use and the development of legislation that regulates the subject. The principle of the 3R's (replacement, reduction and refinement) has been an important reference, such that in vitro, ex vivo and cord replacement methods have achieved a prominent place in research.

Methods: Therefore, due to successful results from studies developed with these methods, the present study aimed to evaluate the myorelaxant effect of the essential oil (EODa) using a coronary artery model, and the toxicity of both the essential oil and its major constituent, α-terpinene, against in toxicity and negative geotaxis assays.

Myorelaxant action of the Dysphania ambrosioides (L.) Mosyakin & Clemants essential oil and its major constituent α-terpinene in isolated rat trachea.

This study aimed to investigate the myorelaxant action of the Dysphania ambrosioides essential oil (EODa) and its major constituent α-terpinene on tracheal smooth muscle isolated from rats. In tracheal smooth muscle ex vivo, in organ baths, isometric contractions recordings were done in order to evaluated the effect of EODa (1-1000 μg/mL) and α-terpinene (1-3000 μg/mL) on the following parameters: basal tone, contractions evoked by potassium (KCl 60 mM), acetylcholine (ACh 10 μM) or serotonin (5-HT 10 μM). The EODa and its major constituent α-terpinene, did not statistically alter basal tone; however, they induced myorelaxant effects on top of contractions induced by KCl, ACh and 5-HT.

Eucalyptol reduces airway hyperresponsiveness in rats following cigarette smoke-exposed.

Background: Cigarette smoke is the major cause of airway inflammatory disease, including airway hyperresponsiveness. Eucalyptol (EUC), also named 1.8-cineole, is a monoterpenoid found in essential oil of medicinal plants, showing several biological effects.

Tocolytic activity of the Lippia alba essential oil and its major constituents, citral and limonene, on the isolated uterus of rats.

The species Lippia alba (Mill.) N. E.

Effect of the (Mill.) N.E. Brown essential oil and its main constituents, citral and limonene, on the tracheal smooth muscle of rats.

The (Mill.) N.E.