Publications by authors named "Renata Castiglioni Pascon"

Cryptococcosis is a fungal infection for which treatment relies on old antifungal agents usually leading to drawbacks such as high toxicity and mainly low efficiency since drug resistance of microorganisms is strongly widespread. The discovery of new antifungal agents is urgent and investigations about underexplored Natural Product (NP) can yield the necessary outcomes to guide the discovery of new prototypes to anti-cryptococcal molecules development. In this scenario, an integrated strategy involving metabolomic data analysis, biological assessement and genome mining of P.

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Fungal pathogens are a major cause of death, especially among immunocompromised patients. Therapies against invasive fungal infections are restricted to a few antifungals; therefore, novel therapies are necessary. Nutritional signaling and regulation are important for pathogen establishment in the host.

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Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules and organelles, essential for cell survival in adverse conditions. More than 40 autophagy-related (ATG) genes have been identified and characterized in fungi, among them ATG4 and ATG8. ATG4 encodes a cysteine protease (Atg4) that plays an important role in autophagy by initially processing Atg8 at its C-terminus region.

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Article Synopsis
  • The increasing use of rubber has caused significant environmental issues due to its long decomposition time, sparking interest in microbial rubber degradation through bioremediation.
  • Research on the G. paraffinivorans MTZ041 isolate revealed the presence of the lcp gene, which helps initiate the breakdown of both natural and synthetic rubber.
  • Growth studies over 11 weeks showed that MTZ041 could thrive on rubber as a carbon source, highlighting its potential role in addressing rubber waste challenges through bioremediation.
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Article Synopsis
  • Hydrocarbons are significant environmental pollutants, and finding new microorganisms that can break them down is crucial for effective biodegradation.
  • Researchers isolated several bacterial strains from compost, specifically targeting those that can degrade n-hexadecane, identifying six isolates as members of the Gordonia genus.
  • Two selected strains, Gordonia paraffinivorans and Gordonia sihwensis, demonstrated impressive degradation rates and unique gene clusters involved in hydrocarbon degradation, highlighting their potential for biotransformation of harmful pollutants.
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The serine-threonine kinase AKT/PKB is a critical regulator of various essential cellular processes, and dysregulation of AKT has been implicated in many diseases, including cancer. Despite AKT action is known to function mainly in the cytoplasm, AKT has been reported to translocate to the nucleus. However, very little is known about the mechanism required for the nuclear import of AKT as well as its function in this cellular compartment.

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Composting is a promising source of new organisms and thermostable enzymes that may be helpful in environmental management and industrial processes. Here we present results of metagenomic- and metatranscriptomic-based analyses of a large composting operation in the São Paulo Zoo Park. This composting exhibits a sustained thermophilic profile (50 °C to 75 °C), which seems to preclude fungal activity.

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The Mre11-Rad50-Nbs1 protein complex has emerged as a central player in the cellular DNA damage response. Mutations in scaANBS1, which encodes the apparent homologue of human Nbs1 in Aspergillus nidulans, inhibit growth in the presence of the anti-topoisomerase I drug camptothecin. We have used the scaANBS1 cDNA as a bait in a yeast two-hybrid screening and report the identification of the A.

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