Is season important for the diagnosis of cutaneous melanoma in southern Brazil? A 10-year hospital-based study.

Background: Exposure to sunlight is an important etiologic factor in cutaneous melanoma (CM). In several countries, more cases of CM are diagnosed in summer than in winter.

Aim: To analyze whether there is seasonal variation in the diagnosis of CM in southern Brazil.

Plasma endothelin-1 levels after coronary stenting in humans.

Endothelin (ET)-1 levels were analyzed in patients who underwent elective coronary stenting. There was a significant increase in systemic ET-1 levels immediately after the procedure, which is probably a marker of endothelial dysfunction that is associated with arterial injury. However, there was no association between ET-1 levels and in-stent restenosis in humans.