Publications by authors named "Renata Almeida de Sa"
Article Synopsis
- Transforming growth factor 1 (TGF-1) plays a key role in the severity of Chagas disease, with higher serum levels linked to worse patient outcomes.
- The study investigated whether specific gene polymorphisms were related to the risk and severity of Chagas disease in a Brazilian population, focusing on five single-nucleotide polymorphisms.
- Results showed that certain genotypes (-509 C>T and +10 T>C) were more common in Chagas patients compared to noninfected individuals, indicating an association with disease susceptibility, but not with the form of the disease.
Objective: To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro and compare the distribution of allele and genotype frequencies of the polymorphisms analyzed in the present study population with other regions in the country and different ethnic groups.
Materials And Methods: We analyzed a sample of the Brazilian population, comprising 196 patients with PCa treated by the urology services of the Brazilian National Cancer Institute (INCA) and Mario Kroeff Hospital (HMK), and 208 male blood donors from the Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro (UFRJ). The polymorphisms were determined in DNA, extracted from peripheral blood leucocytes using the Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP).