Publications by authors named "Renana Yemini"
Background: Efforts to improve the quality of marginal grafts for transplantation are essential. Machine perfusion preservation appears as a promising solution.
Methods: The United Network for Organ Sharing (UNOS) database was queried for deceased liver donor records between 2016 and 2022.
Article Synopsis
- Kidney transplant recipients generally have a higher life expectancy, but the need for multiple transplants raises ethical concerns about organ allocation, which this study addresses through long-term follow-up.
- Conducted at a single center from 2000 to 2019, the study categorized 2152 kidney transplant patients into three groups based on the number of transplants: Group A (1), Group B (2), and Group C (3 or more).
- Results indicated similar rates of death-censored graft failure and overall mortality among all groups, though Group A had a lower risk of graft failure; the strongest predictor of patient and graft survival was identified as having a living donor.
Background: Bariatric surgery (BS) is the optimal approach for sustained weight loss and may alter donation candidacy in potential donors with obesity. We evaluated the long-term effects of nephrectomy after BS on metabolic profile, including body mass index, serum lipids and diabetes, and kidney function of donors.
Methods: This was a single-center retrospective study.
Introduction: Metrics for posttransplant immune monitoring to prevent over or under immunosuppression in renal transplant recipients (RTRs) are lacking.
Methods: We surveyed 132 RTRs, 38 in the first year posttransplant and 94 >1-year posttransplant, to study the clinical expression of immunosuppressive therapy. A questionnaire administered to these RTRs was divided into physical (Q physical) and mental (Q mental) symptoms.
Article Synopsis
- Obesity among kidney transplant recipients is linked to higher risks of mortality and graft failure, prompting a study comparing outcomes between obese (BMI > 30 kg/m²) and non-obese patients, involving 1403 patients from a single center.
- The study found that obese patients had worse survival rates and higher incidence of graft complications, particularly with deceased donor (DD) transplants, indicating a need for closer consideration of metabolic health in these patients.
- Researchers suggest that weight loss strategies, including the use of GLP-1 inhibitors and possible bariatric surgery, could help improve outcomes for obese patients awaiting kidney transplants.
Unlabelled: With scarce organ supply, a selection of suitable elderly candidates for transplant is needed, as well as auditing the long-term outcomes after transplant. We conducted an observational cohort study among our patient cohort >60 years old with a long follow up. (1).
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- The study investigates the safety and effectiveness of bariatric surgery, specifically Roux-en-Y gastric bypass and sleeve gastrectomy, for morbidly obese patients undergoing liver transplantation.
- Eighteen patients were analyzed, showing significant weight loss averages of 31% total and 81% excess weight, with improvements in diabetes management for some.
- Although bariatric surgery proved beneficial for addressing obesity in patients with liver issues, the associated surgical risks were noted to be higher than in typical bariatric surgery scenarios.
Background: The surgical risk of morbidly obese patients is high and even higher for kidney transplant candidates. A BMI > 35-40 kg/m is often a contraindication for that surgery. The safety, feasibility, and outcome of bariatric surgery for those patients are inconclusive.
View Article and Find Full Text PDFBackground: Data on the benefits of bariatric surgery for morbid obesity among kidney transplant recipients are scarce.
Objective: To examine the effect of bariatric surgery on graft function and survival and on obesity-related co-morbidities.
Setting: University hospital.
The surgical risk of transplanted patients is high, and the modified gastrointestinal anatomy after bariatric surgery (BS) may lead to pharmacokinetic alterations in the absorption of immunosuppressive drugs. Data on outcomes of BS and the safety and feasibility of maintaining immunosuppression and graft safety among solid organ transplanted patients are scarce. In the current study, weight loss, improvement in comorbidities, and changes in dosage and trough levels of immunosuppression drugs before and after BS were analyzed for all transplanted patients who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y gastric bypass (LRYGB) in our institution between November 2011 and January 2017.
View Article and Find Full Text PDFBackground: Gastroesophageal reflux disease and inadequate weight loss (IWL) are long-term complications of laparoscopic sleeve gastrectomy (LSG) and indications for a laparoscopic conversion to an alternative bariatric procedure. The aim of this study is to report the long-term outcomes of biliopancreatic diversion with a duodenal switch (DS) or a Roux-en-Y gastric bypass (RYGB) as conversion procedures for weight loss failure after LSG.
Methods: The data of all patients who underwent post-LSG conversion to either a RYGB or a DS at our institution between November 2006 and May 2016 was retrospectively analyzed.
Previously, many morbidly obese (MO) patients were denied liver transplantation (LT) because of the higher operative risk. However, nowadays, 5 and 10 years graft survival is the rule, and patients whose lives can be prolonged with LT are dying of obesity-related comorbidities. Recent experience suggests that weight reduction in MO liver transplant recipients would improve their long-term survival.
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