Publications by authors named "Rena Ubukata"
C-C chemokine receptor type 7 (CCR7) is a member of the G protein-coupled receptor family and functions as a lymph node-homing receptor for immune cells. Upon ligand binding, CCR7 promotes the migration of immune cells to secondary lymphoid organs. In cancers, CCR7 has been revealed as a critical molecule in lymph node metastasis.
View Article and Find Full Text PDFDevelopment of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies.
Biochem Biophys Rep
December 2024
Article Synopsis
- Leukocyte migration is critical for immune responses and is regulated by chemokines, with atypical chemokine receptors (ACKRs) influencing their abundance.
- This study focused on developing novel monoclonal antibodies (mAbs) to target the mouse ACKR4 (mACKR4), which is important for dendritic cell movement and tumor development in mice.
- Three mAbs (AMab-1, AMab-2, and AMab-3) were successfully created, showing effectiveness in detecting mACKR4 through flow cytometry and western blot analysis, indicating their potential use in preclinical research.
Development of Sensitive Anti-Mouse CCR5 Monoclonal Antibodies Using the N-Terminal Peptide Immunization.
Monoclon Antib Immunodiagn Immunother
August 2024
One of the G protein-coupled receptors, C-C chemokine receptor 5 (CCR5), is an important regulator for the activation of T and B lymphocytes, dendritic cells, natural killer cells, and macrophages. Upon binding to its ligands, CCR5 activates downstream signaling, which is an important regulator in the innate and adaptive immune response through the promotion of lymphocyte migration and the secretion of proinflammatory cytokines. Anti-CCR5 monoclonal antibodies (mAbs) have been developed and evaluated in clinical trials for tumors and inflammatory diseases.
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