Publications by authors named "Rena Isogawa"
Article Synopsis
- Drug resistance in malaria parasites hampers effective treatment and control, prompting research into an antimalarial compound, N-89, which has shown promising effects.
- In this study, a N-89-resistant clone, NRC10H, was developed from the Plasmodium falciparum FCR-3 strain, and gene mutations were identified through whole-genome sequencing and real-time PCR.
- Seven genes related to drug resistance showed mutations in NRC10H, with the specific variant A532S in the multidrug resistance protein 2 (mdr2) being unique to this clone, indicating it plays a role in the resistance mechanism against N-89.
Background: With the emergence and growing number of drug-resistant , a new drug for malaria control must be urgently developed. The new antimalarial synthetic compound N-251 was recently discovered. As an endoperoxide structure in the body, the compound shows high antimalarial activity and curative effects.
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