Publications by authors named "RenYi Lu"
Article Synopsis
- Dahuang Mudan decoction (DMD) is a traditional Chinese medicine used to treat infectious diseases, and this study aims to evaluate its effects on septic mice and understand its mechanisms.
- Various tests, including sepsis models and blood tests, showed that DMD and its components significantly improved survival rates and reduced organ damage in septic mice, similar to a positive control drug (Xuebijing injection).
- The study concluded that DMD and its ingredients work by reducing inflammation and coagulation activation, suggesting a promising therapeutic potential for sepsis treatment.
Article Synopsis
- Sepsis is a serious condition caused by an uncontrolled immune response to infection, leading to organ failure and high death rates, but current diagnostic methods for it are not very effective.
- This study explores new potential biomarkers for sepsis by analyzing multiple datasets to identify genes that could help improve diagnosis, culminating in the identification of two specific genes.
- One of these genes showed promise as a diagnostic tool, accurately distinguishing between different types of sepsis and exhibiting notable changes in expression levels in a mouse model of sepsis.
Excessive inflammatory response is a critical pathogenic factor for the tissue damage and organ failure caused by systemic inflammatory response syndrome (SIRS) and sepsis. In recent years, drugs targeting RIPK1 have proved to be an effective anti-inflammatory strategy. In this study, we identified a novel anti-inflammatory lead compound 4-155 that selectively targets RIPK1.
View Article and Find Full Text PDFAntifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine.
Antibiotics (Basel)
December 2022
Fungal infections have become a growing public health challenge due to the clinical transmission of pathogenic fungi. The currently available antifungal drugs leave very limited choices for clinical physicians to deal with such situation, not to mention the long-standing problems of emerging drug resistance, side effects and heavy economic burdens imposed to patients. Therefore, new antifungal drugs are urgently needed.
View Article and Find Full Text PDFNeutrophil extracellular traps in fungal infections: A seesaw battle in hosts.
Front Immunol
October 2022
Fungal infections are a growing health care challenge. Neutrophils play a key role in defense against fungal infections. There are many effective ways for neutrophils to eliminate fungal invaders, such as phagocytosis, oxidative bursts, and the formation of extracellular traps.
View Article and Find Full Text PDFThe incidence of fungal infections has increased continuously in recent years. Caspofungin (CAS) is one of the first-line drugs for the treatment of systemic fungal infection. However, the emerging CAS-resistant clinical isolates and high economic cost for CAS administration hamper the wide application of this drug.
View Article and Find Full Text PDFNew Triazole NT-a9 Has Potent Antifungal Efficacy against Cryptococcus neoformans and .
Antimicrob Agents Chemother
January 2020
In the past decades, the incidence of cryptococcosis has increased dramatically, which poses a new threat to human health. However, only a few drugs are available for the treatment of cryptococcosis. Here, we described a leading compound, NT-a9, an analogue of isavuconazole, that showed strong antifungal activities and NT-a9 showed a wide range of activities against several pathogenic fungi , including , , , , , , and , with MICs ranging from 0.
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