Development of a prognostic gene signature and exploration of P4HA1 in the modulation of cuproptosis in colorectal cancer.

Cuproptosis, a newly identified form of cell death, has drawn increasing attention for its association with various cancers, though its specific role in colorectal cancer (CRC) remains unclear. In this study, transcriptomic and clinical data from CRC patients available in the TCGA database were analyzed to investigate the impact of cuproptosis. Differentially expressed genes linked to cuproptosis were identified using Weighted Gene Co-Expression Network Analysis (WGCNA).

Cost-effectiveness analysis of hepatitis E vaccination strategies among patients with chronic hepatitis B in China.

Aim: This study aimed to evaluate the cost-effectiveness of hepatitis E vaccination strategies in chronic hepatitis B (CHB) patients.

Methods: Based on the societal perspective, the cost-effectiveness of three hepatitis E vaccination strategies-vaccination without screening, screening-based vaccination, and no vaccination-among CHB patients was evaluated using a decision tree-Markov model, and incremental cost-effectiveness ratios (ICERs) were calculated. Values for treatment costs and health utilities were estimated from a prior investigation on disease burden, and values for transition probabilities and vaccination-related costs were obtained from previous studies and government agencies.

Acoustic Insulation Characteristics and Optimal Design of Membrane-Type Metamaterials Loaded with Asymmetric Mass Blocks.

Membrane-type acoustic metamaterials (MAMs) are the focus of the current research due to their lightweight, small size, and good low-frequency sound insulation performance. However, there exists difficulties for extensive application because of the narrow sound insulation band. In order to achieve broadband sound isolation under the premise of lightweight, a novel MAM with asymmetric rings is firstly proposed in this paper.

Acoustic Insulation Mechanism of Membrane-Type Acoustic Metamaterials Loaded with Arbitrarily Shaped Mass Blocks of Variable Surface Density.

Membrane-type acoustic metamaterials (MAMs) have recently received widespread attention due to their good low-frequency sound-transmission-loss (STL) performance. A fast prediction method for the STL of rectangular membranes loaded with masses of arbitrary shapes and surface density values is proposed as a semi-analytical model for calculating the STL of membrane-type acoustic metamaterials. Through conformal mapping theory, the mass blocks of arbitrary shapes were transformed into regular shapes, which simplified the calculation model of acoustic propagation loss prediction, and the prediction results were verified by finite element simulations.

Sound Insulation Performance of Composite Double Sandwich Panels with Periodic Arrays of Shunted Piezoelectric Patches.

The existing sandwich structure of the aircraft cabin demonstrates a good sound insulation effect in medium and high frequency bands, but poor in the low frequency band. Therefore, we propose an infinite new lightweight broadband noise control structure and study its sound transmission loss (STL). The structure is an orthogonally rib-stiffened honeycomb double sandwich structure with periodic arrays of shunted piezoelectric patches, and demonstrates lighter mass and better strength than the existing sandwich structure.

Disease burden concerning hepatitis E-infected inpatients in Jiangsu province, China.

Objective: This study aimed to determine the disease burden of hepatitis E virus (HEV)-infected inpatients in Jiangsu province, China.

Methods: Between July 1, 2016 and October 31, 2018, 1152 HEV-infected inpatients were identified from four cities in Jiangsu province, namely, Nanjing, Suzhou, Yancheng, and Zhenjiang. The disease burden comprised the economic burden and loss of health due to HEV infection.

A Cluster of Bunyavirus-Associated Severe Fever With Thrombocytopenia Syndrome Cases in a Coastal Plain Area in China, 2015: Identification of a Previously Unidentified Endemic Region for Severe Fever With Thrombocytopenia Bunyavirus.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is a typical tick-borne, natural focal disease. The natural foci of SFTS were considered to exist in hilly and mountainous areas before 2015. A cluster of 3 patients exposed to a patient with a fulminant disease consistent with SFTS occurred from July to August 2015 in Dongtai County, which is characterized by alluvial plains; this prompted investigation.

Chemical vapor deposition growth of ReS nanowires for high-performance nanostructured photodetector.

Rhenium disulfide (ReS2) is a recently discovered next-generation transition metal dichalcogenides (TMDs) material that exhibits unique properties, which have resulted in its wide use in the fabrication of electronic and optoelectronic devices. Studies on ReS2 have mainly focused on the synthesis and applications of two-dimensional (2D) materials, while studies on one-dimensional (1D) ReS2 have yet to be reported. Herein, 1D single-crystal ReS2 nanowires have been synthesized successfully for the first time via chemical vapor deposition (CVD) and utilized as the active layer in a nanostructured photodetector.

Interleukin-32 stimulates osteosarcoma cell invasion and motility via AKT pathway-mediated MMP-13 expression.

As a pro-inflammatory cytokine, interleukin-32 (IL-32) is reported to play an important role in tumor development and progression. However, its effects on the invasion and motility of osteosarcoma cells remain elusive. The aim of the present study was to determine the molecular mechanisms of IL-32 in osteosarcoma cells using RT-PCR and western blot analysis.

Long-term efficacy of a hepatitis E vaccine.

Background: Hepatitis E virus (HEV) is a leading cause of acute hepatitis. The long-term efficacy of a hepatitis E vaccine needs to be determined.

Methods: In an initial efficacy study, we randomly assigned healthy adults 16 to 65 years of age to receive three doses of either a hepatitis E vaccine (vaccine group; 56,302 participants) or a hepatitis B vaccine (control group; 56,302 participants).

The association of MDM2 c.346G>A genetic variant with the risk of osteosarcoma in Chinese.

Unlabelled: Previous studies suggest that the MDM2 gene is one of the most important candidate genes for influencing the risk of osteosarcoma. This study aims to investigate the potential association of MDM2 c.346G>A genetic variant with the risk of osteosarcoma in Chinese.

Two-stage nicking enzyme signal amplification combined with DNAzyme amplification for the detection of bone morphogenetic protein 6 mRNA.

Highly sensitive detection of bone morphogenetic protein 6 (BMP6) mRNA is essential to monitor bone regeneration in the regenerating defects. In this work, we proposed a quantitative approach based on two-stage nicking enzyme signal amplification (NESA) and DNAzyme amplification for highly sensitive detection of BMP6 mRNA. The two-stage NESA involves two templates and two-stage amplification reactions under isothermal conditions.

Prospective cohort study of the safety of an influenza A(H1N1) vaccine in pregnant Chinese women.

To monitor and evaluate the safety of the influenza A(H1N1) vaccine in pregnant women and its influence on the fetus and neonate, we performed a prospective study in which 122 pregnant Chinese women who received the influenza A(H1N1) vaccine and 104 pregnant women who did not receive any vaccine (serving as controls) were observed. The results indicated that the seroconversion rate in the vaccinated group was 90.4% (95% confidence interval [CI], 82.

Vibrations of cylindrical objects obstructing a Poiseuille-type flow.

Using the lattice Boltzmann equation, we numerically studied the dynamics of a physical model system, the Poiseuille flow-induced vibrations (PFIV). At a moderate Reynolds number, for flows past a cylinder that is free to move in the cross-flow direction while being fixed in the streamwise direction, between two parallel walls, a variety of distinct vibration regimes involving symmetrical periodic vibration, deflective quasiperiodic vibration, and deflective periodic vibration with corresponding wake states were observed. The data analysis shows that the distribution of the lift coefficient depending on the blockage ratio plays an important role in such a system.

[An epidemiological investigation of the rabies between 1999 - 2008 in Yancheng city, Jiangsu province.].

Objective: To better understand the epidemiology of rabies during the past ten years in Yancheng city, Jiangsu province.

Methods: Data was collected and analyzed on rabies cases in Yancheng. Density and vaccination rate on Canine, Rate of injured people bit by dogs, and the information of post-exposure prophylaxis were studied.

Serologic study on the outbreak of acute upper respiratory tract infections caused by adenovirus 3.

From April to June, 2004, an outbreak of acute upper respiratory tract infections (AURTI) occurred in the north area of Jiangsu Province, China. Twenty throat swabs were collected with 13 of them presenting an adenovirus (Ad)-like cytopathogenic effect on HEp-2. These were verified as Ad by the electron microscope, direct immunofluorescence assay and Ad primer-mediated PCR.

Molecular characterization of rabies virus isolates in China during 2004.

Human rabies cases have been on the rise during the past few years in China and a total of 2651 cases were reported in 2004. To better understand the current rabies epidemics in China, we isolated rabies viruses from dogs and humans from five provinces and characterized these isolates genetically by sequencing the entire nucleoprotein (N) gene. Comparison of the N genes among these isolates revealed 86.

[Sequence analysis of Echovirus type 30 isolated from an aseptic meningitis outbreak in northern Jiangsu province in 2003].

Objective: To determine the partial sequence of virus strains causing an aseptic meningitis outbreak in northern part of Jiangsu province in 2003 and to compare them with the same serotype strains isolated in other countries to better understand its genetic characteristics and hereditary trend of development.

Methods: Virus RNA was amplified using two sets of specific enteroviral 3' half of VP1 primers 012/011 and 040/011. Polymerase chain reaction (PCR) products were purified and sequenced.