Publications by authors named "Ren-Hu Sun"
[Significance of IL-1beta-induced ectopic expression of CDX2 in the intestinal metaplasia of gastric epithelium].
Zhonghua Wei Chang Wai Ke Za Zhi
July 2010
Objective: To evaluate the effect of IL-1beta on the expression of CDX2 in human gastric epithelial cell line GES-1 and its role in the intestinal metaplasia.
Methods: GES-1 cells were treated with IL-1beta in different concentrations and the expressions of CDX2 mRNA and protein were detected by real-time PCR, immunocytochemistry and Western blot at different time points. GES-1 cells were then pre-treated with NF-KappaB pathway inhibitor PDTC, and the expression of CDX2 mRNA and protein induced by IL-1beta were detected.
Background And Objective: Chemokine receptor CCR7 is up-regulated in gastrointestinal carcinomas and is significantly associated with lymphatic invasion and lymph node metastasis. This study was to investigate the role and mechanism of CCL21/CCR7 in invasion of colorectal carcinoma cell line SW480.
Methods: The invasive capacity of SW480 cells was examined using Wound healing assay and Transwell assay.