Publications by authors named "Ren-Fa Huang"
Acute kidney injury (AKI) is one of the most challenging clinical problems in kidney disease due to serious complications and high mortality rate, which can lead to acute lung injury (ALI) through inflammatory reactions and oxidative stress. Adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway has been reported to be involved in the development of renal ischemia-reperfusion through autophagy and it remains unclear whether AMPK/mTOR pathway has an effect on the AKI-induced ALI. In this study, we aimed to investigate the effects of autophagy-related AMPK/mTOR signaling pathway on inflammatory factors and oxidative stress in an AKI-induced ALI model.
View Article and Find Full Text PDFObjective: To investigate protective effect of Cordyceps sinensis (CS) through autophagy-associated adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway in acute kidney injury (AKI)-induced acute lung injury (ALI).
Methods: Forty-eight male Sprague-Dawley rats were divided into 4 groups according to a random number table, including the normal saline (NS)-treated sham group (sham group), NS-treated ischemia reperfusion injury (IRI) group (IRI group), and low- (5 g/kg·d) and high-dose (10 g/kg·d) CS-treated IRI groups (CS1 and CS2 groups), 12 rats in each group. Nephrectomy of the right kidney was performed on the IRI rat model that was subjected to 60 min of left renal pedicle occlusion followed by 12, 24, 48, and 72 h of reperfusion.
Objective: To investigate the effect of both fermented Cordyceps powder (CS) and prednisone on the Notch2/hes-1 signaling activation in the kidney tubules of rats with acute aristolochic acid nephropathy (AAAN).
Methods: Totally 50 SD rats were randomly divided into 4 groups, i.e.
Article Synopsis
- - The study explores how the Notch signaling pathway contributes to inflammation and cell death (apoptosis) following renal ischemia/reperfusion injury (IRI) in male rats, evaluating both the physiological and biochemical changes.
- - Rats were treated with either normal saline or a Notch inhibitor (DAPT) after undergoing kidney damage, and various markers were assessed, including creatinine levels and protein expressions related to inflammation and apoptosis.
- - Results showed that Notch signaling activation worsened kidney damage, but DAPT treatment significantly improved kidney function and reduced inflammation and cell death, highlighting the potential therapeutic role of inhibiting the Notch pathway in renal IRI cases.