Publications by authors named "Ren-Chong Xie"
Article Synopsis
- Complement 1 inhibitor (C1INH) regulates complement cascades and protease activation, with the highest expression of EcC1INH mRNA found in the liver.
- Exposure to Vibrio alginolyticus significantly boosts EcC1INH mRNA levels in both liver and kidney tissues.
- The N-terminal domain of EcC1INH reduces LPS binding to cells and can inhibit LPS-induced inflammation by interfering with proinflammatory cytokine production.
Bcl-2 is a pro-survival member of Bcl-2 like superfamily, playing an important role in regulating the apoptotic process. In this study, the full-length Bcl-2 (EcBcl-2) was obtained, consisting of a 5'UTR of 290 bp, an ORF of 699 bp and a 3'UTR of 920 bp. EcBcl-2 gene encoded a polypeptide of 232 amino acids with an estimated molecular mass of 26.
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- LvMST4 is a protein kinase identified in the shrimp L. vannamei that regulates various cellular processes such as mitosis and immune responses.
- Infection with V. alginolyticus boosts LvMST4 expression, activating the TLR-TRAF6 signaling pathway and leading to changes in hemocyte counts and respiratory burst activity.
- Silencing LvMST4 impacts bacterial clearance, TRAF6 and p38 expression levels, and increases both respiratory burst activity and mortality, indicating its crucial role in the shrimp's immune response.
Molecular cloning and characterization of PTEN in the orange-spotted grouper (Epinephelus coioides).
Fish Shellfish Immunol
November 2016
Article Synopsis
- PTEN is a crucial tumor suppressor gene involved in regulating cell growth, survival, and programmed cell death (apoptosis), with the study isolating the full-length EcPTEN gene, which encodes a 422-amino-acid protein.
- EcPTEN mRNA is widely expressed in various tissues, especially in the liver, and its expression significantly increases in immune tissues of groupers exposed to Vibrio alginolyticus.
- Overexpressing EcPTEN in cells can promote apoptosis and inhibit certain signaling pathways, suggesting it plays an important role in regulating cellular functions and potential disruption of mammalian signaling pathways.