Simultaneous Anti-Tuberculosis and Anti-Tumor Treatment with Immune Checkpoint Inhibitors for Co-Existent Pulmonary Tuberculosis and Advanced Lung Cancer.

Background: Immune checkpoint inhibitors (ICIs) have emerged as the first-line treatment for driver-negative advanced non-small cell lung cancer (NSCLC). However, there is uncertainty regarding the availability and timing of ICI initiation in patients with NSCLC combined with pulmonary tuberculosis (TB). Additionally, the implementation of dual therapy for anti-TB and anti-tumor treatment poses significant challenges in terms of avoiding drug-drug interactions and reducing adverse reactions during clinical diagnosis and treatment.

Developmental validation of a novel all-in one assay of X chromosomal multi-insertion/deletion loci for forensic genetics.

Multi-insertion/deletion polymorphisms (Multi-InDels), as the novel genetic markers, show great potential in forensic research. Whereas, forensic researchers mainly focus on the multi-InDels on the autosomes, which can provide relatively limited information in some complex paternity cases. In this study, a novel X chromosomal multi-InDel multiplex amplification system was designed, containing 22 multi-InDels and one STR locus on the X chromosome.

The harmful effect of ankylosing spondylitis on diabetes mellitus: new evidence from the Mendelian randomization analysis.

Background: While observational research has highlighted a possible link between ankylosing spondylitis (AS) and type 2 diabetes (T2DM), the quality of evidence remains limited, and the causal relationship is yet to be established. This study aims to explore the causal link between AS and T2DM, as well as its impact on traits related to glucose metabolism.

Method: To infer a causal relationship between AS and various diabetes-related traits, including type 1 diabetes (T1DM), T2DM, blood glucose levels, fasting glucose, glycated hemoglobin, and fasting insulin, we employed Mendelian randomization (MR) analysis.

Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions.

In this research, a self-developed panel comprising 22 X chromosomal multi-InDels and one X-STR was used to explore the genetic polymorphisms and forensic characteristics of these loci in Guizhou Miao and Guizhou Bouyei populations. Besides, genetic affiliations among Guizhou Miao, Guizhou Bouyei and Guizhou Han populations were investigated using principal component analysis, STRUCTURE and machine learning methods. The findings indicated that these loci in the male and female samples had comprehensive discrimination powers greater than 0.

Synthesis and performance optimization of CsPbBr/CdS core/shell lead halide perovskite nanocrystals by an ion exchange method.

All-inorganic lead halide perovskite nanocrystals (NCs) have excellent optoelectronic properties and promising applications. Improving the stability of inorganic halide NCs and optimizing their photoluminescence quantum yields (PLQY) has become an urgent task. Constructing core-shell structures is an effective method to improve the environmental stability and PLQY, however, realizing core-shell structured perovskite NCs with good dispersion and multiple perovskites encapsulated within the shell material remains challenging.

Optical degradation correction of manufacturing-perturbed glass-plastic hybrid lens systems via a joint hardware-software optimization framework.

Glass-plastic hybrid lens systems are increasingly critical in various optical applications due to their unique advantages and growing demands. Due to limitations in manufacturing processes and costs, the yield rate of glass-plastic hybrid lens systems in mass production struggles to match that of mature all-plastic ones. In this work, we propose a pioneering joint hardware-software optimization framework designed for correcting optical degradation in manufacturing-perturbed glass-plastic hybrid lens systems.

Persistent flat band splitting and strong selective band renormalization in a kagome magnet thin film.

Magnetic kagome materials provide a fascinating playground for exploring the interplay of magnetism, correlation and topology. Many magnetic kagome systems have been reported including the binary FeX (X = Sn, Ge; m:n = 3:1, 3:2, 1:1) family and the rare earth RMnSn (R = rare earth) family, where their kagome flat bands are calculated to be near the Fermi level in the paramagnetic phase. While partially filling a kagome flat band is predicted to give rise to a Stoner-type ferromagnetism, experimental visualization of the magnetic splitting across the ordering temperature has not been reported for any of these systems due to the high ordering temperatures, hence leaving the nature of magnetism in kagome magnets an open question.

Multicenter validation of automated detection of paramagnetic rim lesions on brain MRI in multiple sclerosis.

Background And Purpose: Paramagnetic rim lesions (PRLs) are an MRI biomarker of chronic inflammation in people with multiple sclerosis (MS). PRLs may aid in the diagnosis and prognosis of MS. However, manual identification of PRLs is time-consuming and prone to poor interrater reliability.

Developmental and validation of a novel small and high-efficient panel of microhaplotypes for forensic genetics by the next generation sequencing.

Background: In the domain of forensic science, the application of kinship identification and mixture deconvolution techniques are of critical importance, providing robust scientific evidence for the resolution of complex cases. Microhaplotypes, as the emerging class of genetic markers, have been widely studied in forensics due to their high polymorphisms and excellent stability.

Results And Discussion: In this research, a novel and high-efficient panel integrating 33 microhaplotype loci along with a sex-determining locus was developed by the next generation sequencing technology.

Emotional labor, fatigue, and presenteeism in Chinese nurses: the role of organizational identification.

Background: Presenteeism has become a significant issue related to health. However, the effect of fatigue and organizational identification on the relationship between emotional labor and presenteeism among Chinese nurses remains unclear. This study aims to explore the correlation of Chinese nurses' emotional labor, fatigue and organizational identification with presenteeism, and to analyze the mediating effect of fatigue and the moderating effect of organizational identification on the relationship between emotional labor and presenteeism.

Strong and anti-swelling nanofibrous hydrogel composites inspired by biological tissue for amphibious motion sensors.

Conductive hydrogel-based sensors are increasingly favored for flexible electronics due to their skin-like characteristics. However, conventional hydrogels suffer from significant swelling in humid environments and poor mechanical properties which largely restrict their applications in wearable electronic devices, especially for underwater sensing. Herein, drawing inspiration from the extracellular matrix (ECM) structure, a TPU-PVAc@AgNPs/MXene nanofibrous hydrogel composite (TPAMH) with excellent mechanical robustness and anti-swelling properties is developed.

The Association Between Social Isolation and Medication Adherence Among Chinese Older Adults With Chronic Diseases: Serial Mediation of Social Support and Loneliness.

Background: Medication adherence is essential for chronic disease management among older adults. Previous studies have shown significant links among social isolation, social support, loneliness, and medication adherence, yet most were based on cross-sectional designs.

Purpose: We conducted a longitudinal cohort study among Chinese older adults with chronic diseases to explore the mediating effects of social support and loneliness in the association between social isolation and medication adherence.

Estimating postmortem interval based on oral microbial community succession in rat cadavers.

The accurate estimation of the postmortem interval has been one of the crucial issues to be solved in forensic research, and it is influenced by various factors in the process of decay. With the development of high-throughput sequencing technology, forensic microbiology has become the major hot topic in forensic science, which provides new research options for postmortem interval estimation. The oral microbial community is one of the most diverse of microbiomes, ranking as the second most abundant microbiota following the gastrointestinal tract.

Single-cell transcriptome revealed dysregulated RNA-binding protein expression patterns and functions in human ankylosing spondylitis.

Objective: To explore the expression characteristics and regulatory patterns of RBPs in different immune cell types of AS, and to clarify the potential key role of RBPs in the occurrence and development of AS disease.

Methods: PBMC sample data from scRNA-seq (HC*29, AS*10) and bulk RNA-seq (NC*3, AS*5) were selected for correlation analysis.

Results: (1) Compared with the HC group, the numbers of B, DC (dendritic cells), CD14 Mono and CD8 T cells were increased in AS group, while the numbers of platelet (platelets), CD8 NKT, CD16 Mono (non-classical monocytes), Native CD4 T and NK were decreased.

Forensic features and phylogenetic structure survey of four populations from southwest China the autosomal insertion/deletion markers.

Unlabelled: Insertion/Deletion (InDel) polymorphisms, characterized by their smaller amplicons, reduced mutation rates, and compatibility with the prevalent capillary electrophoresis (CE) platforms in forensic laboratories, significantly contribute to the advancement and application of genetic analysis. Guizhou province in China serves as an important region for investigating the genetic structure, ethnic group origins, and human evolution. However, DNA data and the sampling of present-day populations are lacking, especially about the InDel markers.

Development, validation, and clinical application of a UPLC-MS/MS method for omadacycline determination in human serum.

Background: Omadacycline is the first aminomethyl-tetracycline variety to successfully enter clinical applications. To support regular therapeutic drug monitoring (TDM) in clinical practice, an ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method was developed that would allow omadacycline quantification in human serum.

Methods: Proteins were precipitated from serum samples using methanol.

Tunable and highly sensitive fluorescent thermometers from LaCaZrO:Cr with a time-resolved technology.

Non-contact optical temperature measurement can effectively avoid the disadvantages of traditional contact thermometry and thus, become a hot research topic. Herein, a fluorescence intensity ratio (FIR) thermometry using a time-resolved technique based on LaCaZrO:Cr (LCZO) is proposed, with a maximum relative sensitivity (Sr - FIR) of 2.56% K at 473 K and a minimum temperature resolution of 0.

Safety, efficacy, and pharmacokinetics of nirmatrelvir and ritonavir in patients with severe COVID-19 and renal impairment: A case report.

Nirmatrelvir/ritonavir (N/r) has received emergency use authorization for mild-to-moderate COVID-19 treatment in adult and pediatric patients (aged and weighing at least 12 years and 40 kg, respectively) presenting positive direct SARS-CoV-2 viral testing results and a high risk of disease progression to severe COVID-19. However, information remains limited concerning the corresponding drug safety, efficacy, and pharmacokinetics in patients with severe renal impairment. In this study, we present the case of a 91-year-old Chinese man who, despite exhibiting recurrent positive SARS-CoV-2 results and progression to severe COVID-19, was treated with N/r.

Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study.

Background: A grim prognosis of pancreatic cancer (PCa) was attributed to the difficulty in early diagnosis of the disease.

Aims: Identifying novel biomarkers for early detection of PCa is thus urgent to improve the overall survival rates of patients.

Methods: The study was performed firstly by identification of candidate microRNAs (miRNAs) in formalin-fixed, paraffin-embedded tissues using microarray profiles, and followed by validation in a serum-based cohort study to assess clinical utility of the candidates.