A Surface-Enhanced Raman Scattering Platform for Rapid, Sensitive, and Cost-Effective Quantitative Analysis of Exosomes Based on Titanium Dioxide Functionalized Nanomaterials.

Exosomes have emerged as vital biomarkers for cancer diagnosis because they carry diverse biomolecules, reflecting the physiological state of their original cells. However, despite this potential, there are still challenges in developing highly sensitive, rapid, and efficient detection methods in clinical diagnosis. Here, we present a straightforward approach for the efficient enrichment and SERS quantification of exosomes via the interaction between titanium dioxide (TiO) and the phospholipid bilayer on the exosome membrane.

Experiences of intimate partner violence among female cancer patients: a meta-synthesis of qualitative research.

Objectives: This research systematically synthesized qualitative studies on intimate partner violence experiences among female cancer patients, aiming to inform the development of relevant psychosocial interventions.

Methods: PubMed, Embase, Web of Science, Scopus, Medline, The Cochrane Library, CINAHL, CNKI, Wanfang, VIP, and Sinomed databases were searched for qualitative studies on intimate partner violence among female cancer patients. The search time frame was from the establishment of the database to April 8 2024.

Scaling relations of spectral form factor and Krylov complexity at finite temperature.

In the study of quantum chaos diagnostics, considerable attention has been attributed to the Krylov complexity and the spectral form factor (SFF) for systems at infinite temperature. These investigations have unveiled universal properties of quantum chaotic systems. By extending the analysis to include the finite-temperature effects on the Krylov complexity and SFF, we demonstrate that the Lanczos coefficients b_{n}, which are associated with the Wightman inner product, display consistency with the universal hypothesis presented in Parker et al.

An unusual transfusion-dependent hemoglobin H disease caused by a novel complex inverted duplication involving the α-globin regulatory elements and α-thalassemia--SEA deletion.

Four multi-species conserved sequences (MCSs) are important enhancers which affect α-globin expression. Deletions of MCS can cause α-thalassemia. So far, duplication of MCS has never been reported to account for thalassemia.

Interpretable Machine Learning Model for Predicting Postpartum Depression: Retrospective Study.

Background: Postpartum depression (PPD) is a prevalent mental health issue with significant impacts on mothers and families. Exploring reliable predictors is crucial for the early and accurate prediction of PPD, which remains challenging.

Objective: This study aimed to comprehensively collect variables from multiple aspects, develop and validate machine learning models to achieve precise prediction of PPD, and interpret the model to reveal clinical implications.

Targeted Modulation of the Meningeal Lymphatic Reverse Pathway for Immunotherapy of Breast Cancer Brain Metastases.

Treatment of tumor brain metastases remains challenging due to the ineffectiveness of drugs in crossing the blood-brain barrier (BBB). Here, we proposed a potential strategy to target and modulate the meningeal lymphatic system for immunotherapy of breast cancer brain metastases (BCBM) through peripheral administration. CT/fluorescence dual-modality imaging demonstrated that the phospholipid nanoprobe (α-PLNPs) through intracisternal magna injection effectively labeled and long-range tracked the meningeal lymphatic pathway from meningeal lymphatic vessels (MLVs) to periphery drainage cervical lymph nodes (CLNs).

PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner.

Small extracellular vesicles (sEVs), carrying PD-L1, have been implicated in immune evasion and tumor progression. However, understanding how PD-L1 sEVs are secreted still needs to be improved. We found that the secretion dynamics of PD-L1 sEVs is similar to that of other sEVs.

Metal-organic frameworks (MOFs): A review of volatile organic compounds (VOCs) detection.

This research presents a systematic review of the application of metal-organic frameworks (MOFs) to detect volatile organic compounds (VOCs). VOCs, compounds with high vapor pressure at ambient temperature and normal pressure, are widely present in a variety of industrial and living environments. VOCs are not only hazardous to the environment but also have a severe impact on human health.

Inhalation exposure to airborne PM attenuates hepatic metabolic pathways through -nitrosylation of the primary ER stress sensor.

Inhalation exposure to airborne fine particulate matter (aerodynamic diameter: <2.5 µm, PM) is known to cause metabolic dysfunction-associated steatohepatitis (MASH) and the associated metabolic syndrome. Hepatic lipid accumulation and inflammation are the key characteristics of MASH.

ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis.

The Mitochondrial Unfolded Protein Response (UPR), a mitochondria-originated stress response to altered mitochondrial proteostasis, plays important roles in various pathophysiological processes. In this study, we revealed that the endoplasmic reticulum (ER)-tethered stress sensor CREBH regulates UPR to maintain mitochondrial homeostasis and function in the liver. CREBH is enriched in and required for hepatic Mitochondria-Associated Membrane (MAM) expansion induced by energy demands.

Modulating and Imaging Macrophage Reprogramming for Cancer Immunotherapy.

Cancer immunotherapy has made great progress in effectively attacking or eliminating cancer. However, the challenges posed by the low reactivity of some solid tumors still remain. Macrophages, as a key component of the tumor microenvironment (TME), play an important role in determining the progression of solid tumors due to their plasticity and heterogeneity.

Reduced expressions of TCA cycle genes during aging in humans and mice.

Aging is associated with a decline in physiological functions and an increased risk of metabolic disorders. The liver, a key organ in metabolism, undergoes significant changes during aging that can contribute to systemic metabolic dysfunction. This study investigates the expression of genes involved in the tricarboxylic acid (TCA) cycle, a critical pathway for energy production, in the aging liver.

Finite-Time Robust Distributed Estimate for Nonlinear Systems With Heterogeneous Sensors.

This article proposes a finite-time distributed state estimation (DSE) algorithm for discrete-time stochastic nonlinear systems with heterogeneous sensors. Considering the network with heterogeneous sensors, the distributed estimate framework is designed by three phases, namely, priori prediction, measurement update, and consensus fusion. To obtain the accurate priori prediction results, the interactive multiple model (IMM) method is adopted to calculate the priori state value in the priori prediction phase.

TIMM9 as a prognostic biomarker in multiple cancers and its associated biological processes.

TIMM9 has been identified as a mediator of essential functions in mitochondria, but its association with pan-cancer is poorly understood. We herein employed bioinformatics, computational chemistry techniques and experiments to investigate the role of TIMM9 in pan-cancer. Our analysis revealed that overexpression of TIMM9 was significantly associated with tumorigenesis, pathological stage progression, and metastasis.

Distributed Asynchronous Constrained Output Formation Optimal Tracking for Multiagent Systems With Intermittent Communications.

Distributed output formation optimal tracking problems for multiagent systems over time-varying topologies with asynchronous and intermittent communications are investigated. Each agent collaboratively computes and tracks the optimal output formation reference that minimizes a global objective function formed by summing local objective functions. Simultaneously, this reference satisfies global constraints composed of local nonlinear inequality constraints and local closed convex set constraints.

Generalized spectral form factor in random matrix theory.

The spectral form factor (SFF) plays a crucial role in revealing the statistical properties of energy-level distributions in complex systems. It is one of the tools to diagnose quantum chaos and unravel the universal dynamics therein. The definition of SFF in most literature only encapsulates the two-level correlation.

Resilient Time-Varying Formation Tracking Control for General Linear Multiagent Systems With a Nonautonomous Leader and Adversarial Followers.

This article is concerned with resilient formation tracking problems for general linear multiagent systems, where the leader's control input is unavailable to all the followers and partial followers' behaviors are malicious due to the node attacks. Despite the presence of the nonautonomous leader and the adversarial followers, the remaining benign followers are still expected to track the leader's trajectory with the prescribed time-varying formation. To this end, a resilient scheme comprising an attack detection and isolation strategy and a formation tracking protocol is proposed.

Gut microbiota dysbiosis links chronic apical periodontitis to liver fibrosis in nonalcoholic fatty liver disease: Insights from a mouse model.

Aim: In this study, we investigated the systemic implications of chronic apical periodontitis (CAP). CAP may contribute to the nonalcoholic fatty liver disease (NAFLD) progression through the gut microbiota and its metabolites, which are related to the degree of fibrosis.

Methodology: Sixteen 7-week-old male apolipoprotein E knockout (apoE) mice were randomly divided into two groups: the CAP and Con groups.

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways.

Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties.

Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway.

Berberine (BBR) is a compound derived from Chinese herbal medicine, known for its anticancer properties through multiple signaling pathways. However, whether BBR can inhibit tumor growth by participating in ferroptosis remains unconfirmed. In this study, we demonstrated that berberine synergistically inhibited NSCLC in combination with multiple ferroptosis inducers, and this combination synergistically down-regulated the mRNA and protein expression of SLC7A11, GPX4, and NRF2, resulting in ferroptosis accompanied by significant depletion of GSH, and aberrant accumulation of reactive oxygen species and malondialdehyde.

Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE Mice on a high-fat diet.

The aim of this study was to explore the impact of chronic apical periodontitis (CAP) on atherosclerosis in apoE mice fed high-fat diet (HFD). This investigation focused on the gut microbiota, metabolites, and intestinal barrier function to uncover potential links between oral health and cardiovascular disease (CVD). In this study, CAP was shown to exacerbate atherosclerosis in HFD-fed apoE mice, as evidenced by the increase in plaque size and volume in the aortic walls observed via Oil Red O staining.

miR-122-3p targets UBE2I to regulate the immunosuppression of liver cancer and the intervention of Liujunzi formula.

Ethnopharmacological Relevance: Liujunzi formula has been used to treat liver cancer in China for many years, but its underlying mechanism remains unclear. We previously found that decreased expression of miR-122-3p was associated with liver cancer. In this study, we aimed to explore the target of miR-122-3p and the effect of the Liujunzi formula on miR-122-3p and its downstream events in liver cancer.