Publications by authors named "Ren Yagami"

Hepatocyte nuclear factor-4α (HNF4α) presents in multiple isoforms generated using alternative promoter (P1 and P2) and splicing. Neither conservation of tissue distribution of HNF4α isoforms, nor presence of alternative promoter usage is known. In this study, to detect the expression of HNF4α in some species of animals, we have applied monoclonal antibodies against P1 (K9218) and P2 (H6939) promoter-driven and P1/P2 promoter-driven H1415 HNF4α for immunohistochemistry and western blot analysis.

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Slit and its receptor Roundabout (Robo) are important for neuronal development and neo-angiogenesis in various neoplastic and non-neoplastic diseases. Angiogenesis is a key factor for tumor growth and other angiogenesis-dependent diseases including rheumatoid arthritis, and chronic inflammation Recently, over-expression of Slit/Robo1 family proteins has been reported in several types of malignancy. We explored the expression of Robo1 in neoplastic and non-neoplastic diseases with a focus on newly formed blood vessels.

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Background: Neuraminidase inhibitors (NAIs) effectively treat influenza. The clinical effectiveness of four NAIs (oseltamivir, zanamivir, laninamivir, and peramivir) was evaluated against influenza A/H1N1pdm09, A/H3N2, and B viruses. Additionally, fever duration in patients infected with oseltamivir-resistant influenza A/H1N1pdm09 with the H275Y mutation was evaluated.

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Article Synopsis
  • The study assessed the effectiveness of the quadrivalent inactivated influenza vaccine (IIV4) introduced in Japan during the 2015-2016 season against various strains of influenza.
  • Out of 713 participants, the adjusted vaccine effectiveness (VE) was found to be low for influenza A (30.0%) and higher for influenza B (50.2%), especially among young children aged 0-5 years.
  • Results indicate that certain strains of A(H1N1)pdm09 had mutations that could affect how well the vaccine works, highlighting the variable effectiveness across different age groups and influenza types.
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We investigated the circulation patterns of human influenza A and B viruses in Myanmar between 2010 and 2015 by analyzing full HA genes. Upper respiratory tract specimens were collected from patients with symptoms of influenza-like illness. A total of 2,860 respiratory samples were screened by influenza rapid diagnostic test, of which 1,577 (55.

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Influenza B viruses of both the Yamagata and the Victoria lineages are implicated in a large proportion of the morbidity and mortality associated with influenza outbreaks. In this study, we characterized the full genomes of 53 influenza B viruses isolated during 2012-2015 in three Asian countries: Japan, Myanmar, and Vietnam. Analysis of the hemagglutinin (HA) genes revealed co-circulation of both the Yamagata and Victoria lineages within the same season in these countries.

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Article Synopsis
  • Influenza A viruses, particularly the A/H3N2 strain, evolve quickly, necessitating ongoing surveillance to ensure vaccines and antiviral treatments remain effective.
  • Analysis of 100 virus isolates from four Asian countries between 2012-2015 identified multiple clades due to reassortment, especially notable during the 2013-2014 seasons.
  • The study highlighted mutations conferring resistance to antiviral drugs, as well as new polymorphisms that could help predict future strains and improve vaccine alignment for upcoming flu seasons.
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The current School Health and Safety Act in Japan states that children with influenza infection should stay home until day 6(th) after symptoms onset. This was an amendment of a previous version recommending school return on day 3 after defervescence. Here, we investigated the duration of fever and virus shedding after laninamivir treatment in 7 children infected with influenza A(H3N2) virus and 21 children with influenza B virus in relation to the school return timing recommended by the School Health and Safety Act during the 2011-2012 influenza season.

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