Impact of Youth Health Ambassador Programme on health awareness in youths in Singapore.

Background: The Youth Health Ambassador Programme (YHAP) is a health educational program aimed at empowering youths to become health ambassadors in the community through raising their health awareness and training them in primary health prevention. This study evaluates the effectiveness of YHAP in improving the knowledge, attitudes, and practices (KAP) of participants in physical and mental health.

Materials And Methods: This study followed a single-group quasi-experimental design, with a pre- and postworkshop KAP survey.

Exposure to air pollution and cognitive function based on the minimum mental state examination: a systematic review and meta-analysis.

Evidence regarding the cognitive effects of air pollution is inconsistent. This study aimed to quantitatively analyze the relationship between air pollutants and cognitive abilities using the Mini-Mental State Examination (MMSE). We systematically searched for studies published until July 1, 2023, and assessed heterogeneity with Cochran's Q test and I² statistics, while publication bias was evaluated using Funnel plots and Egger's test.

Lavender improves sleep through olfactory perception and GABAergic neurons of the central amygdala.

Ethnopharmacological Relevance: The use of lavender as sleep aid or hypnotic agent can be traced back as early as ancient Romans and Greeks. Yet, objective experimental data on whether and how lavender enhances sleep duration or/and sleep quality remain lacking.

Aim Of The Study: We aimed to characterize the sleep-wake regulating effects of lavender in the mouse and to demonstrate the brain targets and neural circuits involved.

Establishment of a transgene-free iPS cell line (SDCHi002-A) from a young patient bearing a NPRL3 mutation and suffering from Epilepsy.

Epilepsy affects ∼ 65 million people worldwide. In this study, peripheral blood mononuclear cells were isolated from a young patient patient bearing a Nitrogen Perntease Regulator Like 3 Protein (NPRL3) mutation and suffering from Epilepsy verified by clinical and genetic diagnosis. Induced pluripotent stem cells (iPSCs) were established by a non-integrative method, using plasmids carrying OCT4, SOX2, KLF4, BCL-XL and C-MYC.

The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment.

Pancreatic ductal adenocarcinoma (PDAC) is a common malignant tumor of the digestive tract. Although gemcitabine and other therapeutic agents are effective in patients with advanced and metastatic pancreatic cancer, drug resistance has severely limited their use. However, the mechanisms of gemcitabine resistance in pancreatic cancer are poorly understood.

Microplastics-biofilm in aquatic ecosystem: Formation, pollutants complexation, greenhouse gas emission and ecotoxicology.

The omnipresent microplastics (MPs) have gradually become a significant environmental problem due to its adverse consequences for ecological systems. MPs serve as substrates for biofilms colonization, which enhances adsorption of harmful contaminants on MPs surface in the aquatic ecosystem. The present study provides a critical discussion on the mechanism involved in MPs-biofilm formation, microbial colonization and the robust factors influencing the process in the aquatic ecosystem.

Synergistic variation in abscisic acid and brassinolide treatment signaling component alleviates fruit quality of 'Shine Muscat' grape during cold storage.

Grape fruit are harvested in the late summer or early fall and need to be stored at low temperatures to prevent enfeeblement and prolong their shelf-life. This study aimed to determine the effects of abscisic acid (ABA), brassinolide (BR) and ABA + BR (ABR) treatment on the berry quality of 'Shine Muscat' under low temperatures. ABA and BR maintained fruit appearance, cellular structure, weight, firmness.

Chromobacterium violaceum infections in children: two case reports and literature review.

Purpose: Chromobacterium violaceum(C. violaceum) is a gram-negative bacterium that rarely infects humans, especially children. However, the mortality rate is high and there are no clear guidelines for treatment.

NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research.

NIAGADS is the National Institute on Aging (NIA) designated national data repository for human genetics research on Alzheimer's Disease and related dementia (ADRD). NIAGADS maintains a high-quality data collection for ADRD genetic/genomic research and supports genetics data production and analysis. NIAGADS hosts whole genome and exome sequence data from the Alzheimer's Disease Sequencing Project (ADSP) and other genotype/phenotype data, encompassing 209,000 samples.

Development of an evaluation system for rational drug use in patients with chronic kidney disease using the Delphi method.

Background: Chronic kidney disease (CKD) stages 3-4 present a significant clinical challenge due to the absence of a systematic approach to managing associated medication-related problems (MRPs). This lack of a structured framework hinders the timely identification and effective intervention for these complications, potentially compromising patient safety and prognosis.

Objective: This study aims to leverage the Delphi method to establish an evaluation index for a rational drug use evaluation system dedicated to CKD patients in stages 3-4.

Synergetic construction of color and multifunction for sustainable lyocell fabric by Coptis chinensis and BTCA.

In the context of escalating standards of living, the demand for healthy and multifunctional textiles is increasing. As a kind of cellulose macromolecular-based material, lyocell fiber has low carbon, is environmentally friendly, and demonstrates superb performance. The utilization of some Chinese herb dyes solves the pollution problem in the color and functionality construction of lyocell fabric by synthetic dyes and finishing agents.

Renal function and risk of dementia: a Mendelian randomization study.

Background: The burgeoning recognition of the nexus between renal functionality and the prevalence of dementia has precipitated a surge in research endeavors. This study aims to substantiate the causal relationship between kidney functionality and dementia.

Methods: We utilized clinical renal function metrics from the Chronic Kidney Disease Genetics (CKDGen) Consortium and diverse dementia types (Alzheimer's disease [AD] and vascular dementia) from the FinnGen Biobank by using Mendelian randomization analysis.

Morphological characteristics of CT blend sign predict hematoma expansion and outcomes in intracerebral hemorrhage in elderly patients.

Background And Purpose: The underlying basis of the blend sign on brain computed tomography (CT) in patients with intracerebral hemorrhage (ICH) is unclear. Few studies have examined the morphological alterations in the CT blend sign in ICH. Therefore, we assessed changes in the CT blend sign and their association with hematoma expansion (HE) and adverse outcomes in ICH patients.

Improved HER/OER Performance of NiS/MoS Composite Modified by CeO and LDH.

In recent years, there has been significant interest in transition-metal sulfides (TMSs) due to their economic affordability and excellent catalytic activity. Nevertheless, it is difficult for TMSs to achieve satisfactory performance due to problems such as low conductivity, limited catalytic activity, and inadequate stability. Therefore, a catalyst with a heterostructure constituted of a nickel-iron-layered double hydroxide, nickel sulfide, molybdenum disulfide, and cerium dioxide was designed.

Effect of Deposit Scale on Mechanical Properties of In-Situ Alloyed CrCoNi Medium Entropy Alloys Formed by Directed Energy Deposition.

Directed energy deposition (DED), as an additive manufacturing technology, has shown unique advantages in multi-material additive manufacturing and remanufacturing. In this study, two types in-situ alloyed CrCoNi medium entropy alloys that have thin-walled structures with different thicknesses (T1 and T2) were manufactured by the DED process, and the mechanisms of differences in relative density, microstructure, and mechanical properties at different heights were systematically analyzed. In terms of microstructure, the T1 and T2 samples along the building direction exhibit significant differences in crystallographic orientation, grain size, and dislocation density, which are related to the local temperature gradient differences caused by the scanning path and heat accumulation.

Evaluation of Female Recipient Infertility and Donor Spermatogonial Purification for Germ Cell Transplantation in .

Since the advent of germ cell transplantation (GCT), it has been widely used in shortening the fish breeding cycle, sex-controlled breeding and the protection of rare and endangered fish. In this study, the effectiveness of female sterile recipient preparation and donor stem cell isolation and purification were comprehensively evaluated for spermatogonial stem cell transplantation (SSCT) in . The best way to prepare sterile recipients was found to be giving three-year-old fish four intraovarian injections of busulfan (20 mg/kg body weight) combined with exposure to a high temperature (28 °C) after the spawning season compared with the two other ways, which induced apoptosis of most of the endogenous germ cells, resulting in shrinkage of the spawning plate and enlargement of the ovarian lumen.