Natribaculum breve gen. nov., sp. nov. and Natribaculum longum sp. nov., halophilic archaea isolated from saline soil.

Two halophilic archaeal strains, TRM20010(T) and TRM20345(T), were isolated from saline soil of the Lop Nur region in Xinjiang, north-west China. Cells from the two strains were pleomorphic rods, stained Gram-negative and produced red-pigmented colonies. Strains TRM20010(T) and TRM20345(T) were able to grow at 30-62 °C (optimum 37 °C), 0.

Synthetic-method-dependent magnetic relaxation in a cobalt(II) phosphonate chain compound.

A polar cobalt(II) phosphonate Co(bamdpH2)(H2O) (1) [bamdpH4 = (benzylazanediyl)bis(methylene)diphosphonic acid] is reported. It shows a linear chain structure. The neighboring chains are connected by moderately strong hydrogen bonds forming a supramolecular layer.

EGR2 is critical for peripheral naïve T-cell differentiation and the T-cell response to influenza.

Early growth response 2 (EGR2) transcription factor negatively regulates T-cell activation, in contrast to the positive regulation of this process by EGR1. Here, we unexpectedly found that EGR2 promotes peripheral naïve T-cell differentiation, with delayed T-cell receptor-induced proliferation in naïve T cells from Egr2 conditional knockout (CKO) mice and decreased production of IFN-γ, IL-4, IL-9, and IL-17A in cells subjected to T-helper differentiation. Moreover, genes that promote T-cell activation, including Tbx21 and Notch1, had decreased expression in Egr2 CKO T cells and are direct EGR2 target genes.

Homochiral cobalt phosphonates containing δ-type chains with a tunable interlayer distance and a field-induced phase transition.

Two pairs of enantiomeric Co(II) compounds with formulas [Co2 (μ3 -OH)(cyamp)(Cn H2n+1 COO)] (cyampH2 =(S)- or (R)-[(1-cyclohexylethyl)amino]methylphosphonic acid; n=1 (1); n=7 (2)) were synthesized. The structures of S-1 and S-2 were determined by single-crystal structural analyses. Both crystallize in a monoclinic chiral space group P21 , and exhibit layered structures in which the Δ-type chains of corner-sharing Co3 (μ3 -OH) triangles are connected by the phosphonate groups.

Influence of hepatic impairment on lenvatinib pharmacokinetics following single-dose oral administration.

This open-label, single-dose study assessed lenvatinib pharmacokinetics (PK) in subjects with normal hepatic function (n = 8) and mild, moderate, or severe hepatic impairment (n = 6 each). Subjects received 10 mg oral lenvatinib, except those with severe hepatic impairment (5 mg). Plasma and urine samples were collected over 14 days; free and total lenvatinib and its metabolites were analyzed using validated chromatography/spectrometry.

Plasma and tissue free amino acid profiles and their concentration correlation in patients with lung cancer.

Variation of plasma free amino acids (PFAAs) is an essential feature of protein metabolic abnormalities in cancer patients. But there still little data about the cancer tissue free amino acid (TFAAs) profiles, including their patterns and correlations with PFAAs. To evaluate the variation in PFAAs and cancer TFAAs in patients with lung cancer, including their patterns and correlations, we investigated the concentrations of free amino acids in lung cancer tissues (n=27), paired lung paracarcinomous tissues (n=27) and plasma (n=27) using an automatic amino acid analyzer after pre-treatment.

Control of the single-molecule magnet behavior of lanthanide-diarylethene photochromic assemblies by irradiation with light.

Lanthanide-based extended coordination frameworks showing photocontrolled single-molecule magnet (SMM) behavior were prepared by combining highly anisotropic Dy(III) and Ho(III) ions with the carboxylato-functionalized photochromic molecule 1,2-bis(5-carboxyl-2-methyl-3-thienyl)perfluorocyclopentene (H2 dae), which acts as a bridging ligand. As a result, two new compounds of the general formula [{Ln(III) 2 (dae)3 (DMSO)3 (MeOH)}⋅10 MeOH]n (M=Dy for 1 a and Ho for 2) and two additional pseudo-polymorphs [{Dy(III) 2 (dae)3 (DMSO)3 (H2 O)}⋅x MeOH]n (1 b) and [{Dy(III) 2 (dae)3 (DMSO)3 (DMSO)}⋅x MeOH]n (1 c) were obtained. All four compounds have 2D coordination-layer topologies, in which carboxylate-bridged Ln2 units are linked together by dae(2-) anions into grid-like frameworks.

Effect of rifampicin on the pharmacokinetics of lenvatinib in healthy adults.

Background And Objectives: Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor under clinical investigation in solid tumours. This study evaluated the influence of P-glycoprotein (P-gp) inhibition (single-dose rifampicin) and simultaneous cytochrome P450 3A4 (CYP3A4)/P-gp induction (multiple-dose rifampicin) on lenvatinib pharmacokinetics.

Methods: This Phase I, single-centre, single-dose (lenvatinib mesylate 24 mg), open-label, sequential study enrolled 15 healthy volunteers.

A luminescent heptanuclear DyIr6 complex showing field-induced slow magnetization relaxation.

The first example of iridium/lanthanide phosphonates, i.e. [DyIr6(ppy)12(bpp)2(bppH)4](CF3SO3)·8H2O (1) (ppy(-) = 2-phenylpyridine, bpp(2-) = 2-pyridylphosphonate) is reported.

A layered erbium phosphonate in pseudo-D(5h) symmetry exhibiting field-tunable magnetic relaxation and optical correlation.

A layered erbium(III) phosphonate compound, [Er(notpH4)(H2O)]ClO4·3H2O (1), in which the Er(III) ion has a pseudo-D5h symmetry exhibits field tunable multiple magnetic relaxation. The near-IR emission spectrum of 1, excited at 1064 nm (Nd:YAG laser), provides a direct probe of the crystal field splitting correlated to the magnetic data.

Expression and function of kisspeptin during mouse decidualization.

Background: Plasma kisspeptin levels dramatically increased during the first trimester of human pregnancy, which is similar to pregnancy specific glycoprotein-human chorionic gonadotropin. However, its particular role in the implantation and decidualization has not been fully unraveled. Here, the study was conducted to investigate the expression and function of kisspeptin in mouse uterus during early pregnancy and decidualization.

QPEEG analysis of the effects of sodium valproate on adult Chinese patients with generalized tonic-clonic seizures.

Objectives EEG effects of the sustained-release form of sodium valproate (SR-VPA) are unknown, although it is widely used in Chinese patients with generalized tonicclonic seizures (GTCS). Methods Fourteen newly diagnosed, untreated GTCS patients were recruited and treated with SR-VPA. Waking EEG was recorded and analyzed by way of quantitative pharmaco-electroencephalogram (QPEEG) analysis during the three-month follow-up.

[Nipple reduction by using a modified Z-shaped incision technique].

Objective: To explore an ideal surgical method for nipple hypertrophy correction.

Methods: From July 2008 to June 2011, 44 nipple reductions were performed for 22 women (44 sides) by using the modified Z-shaped incision technique. The incision consists of two circles, one quadrangle and one triangle located on the top, body and base of the nipple.

1550-nm time-of-flight ranging system employing laser with multiple repetition rates for reducing the range ambiguity.

We demonstrated a time-of-flight (TOF) ranging system employing laser pulses at 1550 nm with multiple repetition rates to decrease the range ambiguity, which was usually found in high-repetition TOF systems. The time-correlated single-photon counting technique with an InGaAs/InP avalanche photodiode based single-photon detector, was applied to record different arrival time of the scattered return photons from the non-cooperative target at different repetition rates to determine the measured distance, providing an effective and convenient method to increase the absolute range capacity of the whole system. We attained hundreds of meters range with millimeter accuracy by using laser pulses of approximately 10-MHz repetition rates.

Effect of lenvatinib (E7080) on the QTc interval: results from a thorough QT study in healthy volunteers.

Purpose: QT assessment of oncology drugs is generally challenging because they are genotoxic and, of necessity,they require multisite evaluation in cancer patients. Lenvatinib is not genotoxic, therefore, this thorough QT (TQT)study with lenvatinib, a multityrosine kinase inhibitor, was undertaken utilizing healthy volunteers and concentration effect modeling to project the TQT effect at high plasma levels.

Methods: Fifty-two healthy subjects randomly received single doses of lenvatinib 32 mg, placebo, or moxifloxacin 400 mg in a three-way crossover study.

Polar metal phosphonate containing unusual μ(4)-OH bridged double chains showing canted antiferromagnetism with large coercivity.

The first examples of metal phosphonates based on an asymmetrical 2-(phosphonomethyl)benzoic acid (2-pmbH3) are reported, namely, Co2(μ4-OH)(2-pmb) (1) and Cu4(μ3-OH)2(2-pmb)2 (2). Both crystallize in polar space groups and show layered structures. Compound 1 contains unusual μ4-OH bridged double chains of {Co2(μ4-OH)O3}, inter-connected by the phosphonate groups.

Panax notoginseng saponins inhibits atherosclerotic plaque angiogenesis by down-regulating vascular endothelial growth factor and nicotinamide adenine dinucleotide phosphate oxidase subunit 4 expression.

Objective: To investigate the mechanism of Panax notoginseng saponins (PNS), an effective component extracted from Panax notoginseng, on atherosclerotic plaque angiogenesis in atherosclerosis-prone apolipoprotein E-knockout (ApoE-KO) mice fed with high-fat, high-cholesterol diet.

Methods: Twenty ApoE-KO mice were divided into two groups, the model group and the PNS group. Ten normal C57BL/6J mice were used as a control group.

Effect of structural isomerism on magnetic dynamics: from single-molecule magnet to single-chain magnet.

This Paper reports the first examples of O-P-O bridged Mn2(salen)2 (salen = N,N'-bis(salicylidene)ethylenediamine) chain compounds, namely, [Mn2(salen)2(2-FC6H4PO3H)](ClO4)·1/2CH3OH (1) and [Mn2(salen)2(4-FC6H4PO3H)](ClO4) (2). The phosphonate ligands adopt a syn-anti bidentate bridging mode in 1 and a syn-syn bidentate bridging mode in 2, originated from the isomeric phosphonate ligands. The different bridging modes cause a significant change in the Mn-O···O-Mn torsion angle over the O-P-O bridge, which are 96.

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression.

Interleukin 9 (IL-9) is a γc-family cytokine that is highly produced by T-helper 9 (Th9) cells and regulates a range of immune responses, including allergic inflammation. Here we show that IL-2-JAK3-STAT5 signaling is required for Th9 differentiation, with critical STAT5 binding sites in the Il9 (the gene encoding IL-9) promoter. IL-2 also inhibited B cell lymphoma 6 (BCL6) expression, and overexpression of BCL6 impaired Th9 differentiation.

Evaluation of the effects of formulation and food on the pharmacokinetics of lenvatinib (E7080) in healthy volunteers.

Objective: To evaluate the effect of formulation and a high-fat meal on the pharmacokinetics of orally administered lenvatinib (E7080).

Materials: Lenvatinib 10-mg capsule and tablet.

Methods: Pharmacokinetics and safety of a single 10-mg lenvatinib dose were evaluated in healthy subjects in two randomized, two-period, crossover, phase 1, bioavailability trials.

Tuning the coordination geometries and magnetic dynamics of [Ln(hfac)4](-) through alkali metal counterions.

Four lanthanide compounds with formulas [Cs{Dy(hfac)4}] (1), [Cs{Er(hfac)4}] (2), [K{Dy(hfac)4}] (3), and [K{Er(hfac)4}] (4) (hfac = hexafluoroacetylacetone) are reported. Compounds 1 and 2 crystallize in the orthorhombic Pbcn space group, while 3 and 4 are in the triclinic P1̅ space group. All display chain structures in which the mononuclear [Ln(hfac)4](-) anions are linked by alkali metal ions.

Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China.

Environmental exposure to heavy metals is a well-known risk factor for cancers. To evaluate potential health risks of heavy metals (Cr, Cd, Pb, As and Hg) and Se in cultivated topsoil and grains, we investigated the concentrations of Hg, As and Se using atomic fluorescence spectrometry and Cr, Cd and Pb using inductive coupled plasma emission spectrometry (ICP-MS). We also analyzed human cancer tissues for heavy metals.

Cobalt phosphonates based on 4-(ethoxycarbonyl)naphthalen-1-yl)phosphonic acid.

The first examples of metal phosphonates based on 4-(ethoxycarbonyl)naphthanen-1-yl)phosphonic acid (4-cnppH2) are reported, namely, Co(4-cnpp) (1), Co2(4-cnpp)2(dptz) (2) and Co2(4-cnpp)2(4,4'-bpy)(H2O) (3) (dptz = 3,6-di(pyridin-3-yl)-1,2,4,5-tetrazine, 4,4'-bpy = 4,4'-bipyridine). The cobalt atoms are four-coordinated with distorted tetrahedral geometries in both 1 and 2, while five-coordinated with a distorted trigonal bipyramidal environment in compound 3. Compound 1 shows a layer structure in which the inorganic layers made up of edge-sharing {CoNO3} dimers and {PO3C} linkages are separated by the organic groups of the 4-cnpp(2-) ligands.

Qindan capsule changes adventitial collagen synthesis in spontaneously hypertensive rats.

Objective: To investigate the effect of Qindan capsule (QC) on collagen synthesis and the mechanism underlying the process in spontaneously hypertensive rats (SHRs).

Methods: Twentyfour SHRs were divided into three groups: the hypertension model group, the QC treatment group, and the losartan treatment group. Eight Wistar Kyoto (WKY) rats were used as the normal control group.

A mononuclear cobalt(II)-dithienylethene complex showing slow magnetic relaxation and photochromic behavior.

Mononuclear complex Co(hpbdti)2·3CH3OH (1) was synthesized [hpbdtiH = 2-(2-hydroxyphenyl)-4,5-bis(2,5-dimethyl(3-thienyl))-1H-imidazole], showing multiple-step field-induced slow magnetic relaxation behaviors, and photochromic properties in CH2Cl2-CH3CN solution.