Metal halide luminescent materials, particularly those doped with ns ions, exhibit exceptional optical properties. However, the luminescent mechanisms associated with the stereochemical activity of lone-pair electrons remain insufficiently explored. In this study, zero-dimensional (0D) tin-based halide (CHN)SnCl is utilized as a model system to investigate the effects of lattice distortion and lone-pair electron expression on fluorescence emission characteristics by doping with 6s and 5s ions.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
Electrocatalytic hydrogen production offers a promising solution to address current energy depletion. Herein, a RuNi/MoN heterostructure on carbon cloth (CC), RuNi/MoN@CC, was successfully constructed using a simple method, allowing for dual regulation of morphology and electronic structure. Under the influence of Ni, the in-situ generated MoN inherits the morphology of the NiMoO precursor, presenting a nanowire morphology, which is favorable for increasing electrochemical active area.
View Article and Find Full Text PDFDynamic gain control of aversive signals enables adaptive behavioral responses. Although the role of amygdalar circuits in aversive processing is well established, the neural pathway for amplifying aversion remains elusive. Here, we show that the brainstem circuit linking the interpeduncular nucleus (IPN) with the nucleus incertus (NI) amplifies aversion and promotes avoidant behaviors.
View Article and Find Full Text PDFEfficient homing of infused hematopoietic stem and progenitor cells (HSPCs) into the bone marrow (BM) is the prerequisite for successful hematopoietic stem cell transplantation. However, only a small part of infused HSPCs find their way to the BM niche. A better understanding of the mechanisms that facilitate HSPC homing will help to develop strategies to improve the initial HSPC engraftment and subsequent hematopoietic regeneration.
View Article and Find Full Text PDFFull-Stokes polarization detection, with high integration and portability, offers an efficient path toward next-gen multi-information optoelectronic systems. Nevertheless, current techniques relying on optical filters create rigid and bulky configurations, limiting practicality. Here, a flexible, filter-less full-Stokes polarimeter featuring a uniaxial-oriented chiral perovskite film is first reported.
View Article and Find Full Text PDFRoad damage is a great threat to the service life and safety of roads, and the early detection of pavement damage can facilitate maintenance and repair. Street view images serve as a new solution for the monitoring of pavement damage due to their wide coverage and regular updates. In this study, a road pavement damage dataset, the Street View Image Dataset for Automated Road Damage Detection (SVRDD), was developed using 8000 street view images acquired from Baidu Maps.
View Article and Find Full Text PDFBackground: Without a pseudocapsule, prostate cancer is invasive in volume growth and has some regularity in spatial distribution. Our study aims to explore the specific origin location, invasive characteristics, and morphology of prostate cancer.
Methods: Ninety-eight clinical specimens with tumor volume equal to or less than one-third of the organ volume and 111 autopsy specimens were retrospectively analyzed.
Neuroinflammation and oxidative stress damage are involved in the pathogenesis of cerebral ischemia-reperfusion injury (CIRI). Ferroptosis emerged as a new player in the regulation of lipid peroxidation processes. This study aimed at exploring the potential involvement of ciprofol on ferroptosis-associated CIRI and subsequent neurological deficits in the mouse model of transient cerebral ischemia and reperfusion.
View Article and Find Full Text PDFFront Cell Neurosci
October 2023
Understanding the developmental changes that affect neurons is a key step in exploring the assembly and maturation of neural circuits in the brain. For decades, researchers have used a number of labeling techniques to visualize neuronal morphology at different stages of development. However, the efficiency and accuracy of neuronal labeling technologies are limited by the complexity and fragility of neonatal brains.
View Article and Find Full Text PDFMetastasis is the leading cause of high ovarian-cancer-related mortality worldwide. Three major processes constitute the whole metastatic cascade: invasion, intravasation, and extravasation. Tumor cells often reprogram their metabolism to gain advantages in proliferation and survival.
View Article and Find Full Text PDFRIG-I-MAVS signaling pathway plays a crucial role in defending against pathogen infection and maintaining immune balance. Upon detecting viral RNA, RIG-I triggers the formation of prion-like aggregates of the adaptor protein MAVS, which then activates the innate antiviral immune response. However, the mechanisms that regulate the aggregation of MAVS are not yet fully understood.
View Article and Find Full Text PDFInt Immunopharmacol
July 2023
Background: NLR family pyrin domain-containing 3 (NLRP3)-mediated pyroptosis plays a key role in various acute and chronic inflammatory diseases. Targeted inhibition of NLRP3-mediated pyroptosis may be a potential therapeutic strategy for various inflammatory diseases. Ergolide (ERG) is a sesquiterpene lactone natural product derived from the traditional Chinese medicinal herb, Inula britannica.
View Article and Find Full Text PDFBackground: Acute tubular necrosis (ATN) is a common type of acute renal failure. Recent studies have shown that NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-mediated pyroptosis in macrophages plays a crucial role in the progression of ATN. Previously, we synthesized an anti-inflammatory compound 15a based on Tanshinone IIA (Tan IIA).
View Article and Find Full Text PDFAcetamide- or formamide-assisted in situ strategy is designed to synthesize carbon atom self-doped g-C N (AHCN ) or nitrogen vacancy-modified g-C N (FHCN ). Different from the direct copolymerization route that suffers from the problem of mismatched physical properties of acetamide (or formamide) with urea, the synthesis of AHCN (or FHCN ) starts from a crucial preorganization step of acetamide (or formamide) with urea via freeze drying-hydrothermal treatment so that the chemical structures as well as C-doping level in AHCN and N-vacancy concentration in FHCN can be precisely regulated. By using various structural characterization methods, well-defined AHCN and FHCN structures are proposed.
View Article and Find Full Text PDFSepsis-induced cardiomyopathy (SIC) is one of the most common complications of infection-induced sepsis. An imbalance in inflammatory mediators is the main factor leading to SIC . N 6 -methyladenosine (m 6 A) is closely related to the occurrence and development of sepsis.
View Article and Find Full Text PDFA qualitative and quantitative analysis of metabolites was performed by metabolomics comparation on the pericarps of four varieties of Maxim. The as scion combined with three rootstock varieties of Maxim (YJ), July Maxim (QJ), and August Maxim (BJ), at the same time seedlings breeding were compared as control (MJ). A total of 1429 metabolites were identified in Maxim pericarps based on chromatography and mass spectrometry dual detection platform.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
October 2022
Through synaptic connections, long-range circuits transmit information among neurons and connect different brain regions to form functional motifs and execute specific functions. Tracing the synaptic distribution of specific neurons requires submicron-level resolution information. However, it is a great challenge to map the synaptic terminals completely because these fine structures span multiple regions, even in the whole brain.
View Article and Find Full Text PDFLiposomes are the most widely used nanocarrier platform for the delivery of therapeutic and diagnostic agents, and a number of liposomes have been approved for use in clinical practice. After systemic administration, most liposomes are cleared by macrophages in the mononuclear phagocyte system, such as the liver and bone marrow (BM). However, the majority of studies have focused on investigating the therapeutic results of liposomal drugs, and too few studies have evaluated the potential side effects of empty nanocarriers on the functions of macrophages in the mononuclear phagocyte system.
View Article and Find Full Text PDFBackground: Danqi soft capsule (DQ) is a Chinese herb medicine with a remarkable protective effect on cardio-cerebrovascular diseases.
Purpose: The study aimed to investigate the role and mechanism of DQ on left atrial (LA) remodeling and atrial fibrillation (AF) occurrence in rats with post-myocardial infarction (MI) induced heart failure (HF).
Methods: MI in rats was established by ligation of the left anterior descending coronary artery.
Photoelectrocatalytic technology has proven to be an efficient way of degrading organic contaminants, including dyes. Graphene (GR) -based catalysts have been frequently used in photoelectrocatalysis, due to their excellent catalytic performances. In this work, the GR/beta-cyclodextrin (GR/β-CD) composite was prepared and used for a widely used triphenylmethane dye (bromophenol blue, BPB) photoelectrocatalytic degradation.
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