Sublingual Edaravone Dexborneol for the Treatment of Acute Ischemic Stroke: The TASTE-SL Randomized Clinical Trial.

Importance: Sublingual edaravone dexborneol, which can rapidly diffuse and be absorbed through the oral mucosa after sublingual exposure, is a multitarget brain cytoprotection composed of antioxidant and anti-inflammatory ingredients edaravone and dexborneol.

Objective: To investigate the efficacy and safety of sublingual edaravone dexborneol on 90-day functional outcome in patients with acute ischemic stroke (AIS).

Design, Setting, And Participants: This was a double-blind, placebo-controlled, multicenter, parallel-group, phase 3 randomized clinical trial conducted from June 28, 2021, to August 10, 2022, with 90-day follow-up.

Efficacy and safety of Y-2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double-blind placebo-controlled multicentre trial.

Background And Purpose: Clinical studies have demonstrated that edaravone dexborneol can improve the functional outcomes in patients with acute ischaemic stroke (AIS). The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outcome in patients with AIS.

Methods And Design: This is a randomised, double-blind, placebo-controlled, multicentre, parallel-group trial of Y-2 sublingual tablet on patients with AIS.

Partial Consistency for Stabilizing Undiscounted Reinforcement Learning.

Undiscounted return is an important setup in reinforcement learning (RL) and characterizes many real-world problems. However, optimizing an undiscounted return often causes training instability. The causes of this instability problem have not been analyzed in-depth by existing studies.

Orientation-Preserving Rewards' Balancing in Reinforcement Learning.

Auxiliary rewards are widely used in complex reinforcement learning tasks. However, previous work can hardly avoid the interference of auxiliary rewards on pursuing the main rewards, which leads to the destruction of the optimal policy. Thus, it is challenging but essential to balance the main and auxiliary rewards.

Research on Tire Marking Point Completeness Evaluation Based on K-Means Clustering Image Segmentation.

The tire marking points of dynamic balance and uniformity play a crucial guiding role in tire installation. Incomplete marking points block the recognition of tire marking points, and then affect the installation of tires. It is usually necessary to evaluate the marking point completeness during the quality inspection of finished tires.

Preparation and characterization of N-succinyl-N'-octyl chitosan micelles as doxorubicin carriers for effective anti-tumor activity.

N-Succinyl-N'-octyl chitosan (SOC) was prepared and characterized by elemental analysis, FTIR, (1)H NMR, WAXD and TG. An anticancer drug, doxorubicin (DOX), was incorporated into polymeric micelles forming by SOC in aqueous solutions. Critical micelle concentrations (CMC) of SOC were determined by fluorescence spectroscopy.