Hydrochemical fingerprints and health risk assessment of groundwater contamination in the Bohai Sea region, China.

Seawater intrusion and human activities have significantly impacted coastal groundwater quality in many regions worldwide. This study systematically assessed groundwater chemistry, its suitability for drinking and irrigation (sample size, n = 3034), and exposure risks (n = 2863) across three key sub-regions of the Bohai Sea area: Bohai Bay, Liaodong Bay, and Laizhou Bay. Significant seasonal variations observed in groundwater chemistry at different depths in Bohai Bay region, with severe contamination from salinity-alkalinity and nitrogen-fluoride.

Rhodium(III)-Catalyzed Sequential Cyclization of Enaminones with 1,3-Dienes via C-H Activation for the Synthesis of Fluorenones.

An efficient method for construction of various fluorenones has been achieved via Rh(III)-catalyzed C-H activation/[4 + 2] annulation/aromatization sequences of simple and readily available enaminones and 1,3-dienes. This protocol showed good substrate compatibility as an array of structurally and electronically diverse fluorenones prepared efficiently in moderate to good yields and preparative scale utility showing very good efficiency in the late-stage functionalization of complex valuable molecules.

Knowledge, attitude, and willingness toward breast magnetic resonance imaging screening among women at high risk of breast cancer in Beijing, China.

Background: Annual breast magnetic resonance imaging (MRI) is highly recommended to assist mammography for women at high risk of breast cancer (BC). This study explored the knowledge, attitude, and willingness toward breast MRI screening among women at high risk of BC.

Methods: This cross-sectional study enrolled women at high risk of BC between August 2022 and January 2023 in Beijing, China.

Dual-Band Monopole MIMO Antenna Array for UAV Communication Systems.

This study proposes a compact, low-profile, four-port dual-band monopole multiple-input-multiple-output (MIMO) antenna array for unmanned aerial vehicle (UAV) communication systems. Each monopole antenna of the array features a modified T-shaped radiator configuration and is printed on a Rogers RT5880 substrate with compact dimensions of 134.96 mm × 134.

Strategic Multi-Omics Data Integration via Multi-Level Feature Contrasting and Matching.

The analysis and comprehension of multi-omics data has emerged as a prominent topic in the field of bioinformatics and data science. However, the sparsity characteristics and high dimensionality of omics data pose difficulties in terms of extracting meaningful information. Moreover, the heterogeneity inherent in multiple omics sources makes the effective integration of multi-omics data challenging To tackle these challenges, we propose MFCC-SAtt, a multi-level feature contrast clustering model based on self-attention to extract informative features from multi-omics data.

Potential of CO sequestration by olivine addition in offshore waters: A ship-based deck incubation experiment.

Ocean alkalinity enhancement is considered as an effective atmospheric CO removal approach, but currently, little is known about the carbon sequestration potential of implementing olivine addition in offshore waters. We investigated the effect of olivine addition on the seawater carbonate system by carrying out a deck incubation experiment in the Northern Yellow Sea; the dissolution rate of olivine was calculated based on the increase in seawater alkalinity (TA), and the CO sequestration potential was evaluated. The results showed that the dissolution of olivine increased seawater TA and decreased partial pressure of CO, resulting in oceanic CO uptake from the atmosphere through sea-air exchange; it also increased seawater pH and mitigated ocean acidification to a certain extent.

PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression.

Background: Osteosarcoma is originated from skeletal system. Recombinant human proteoglycan 4 (rhPRG4) can inhibit cell proliferation and migration in multiple cancers. This research is designed to dig out the role and mechanism of PRG4 in osteosarcoma.

Fluorescence visualization of CO-responsive phase transfer materials targeting at the heterogeneous interfacial reactions in advanced oxidation of naphthenic acid in wastewater.

Treatment of naphthenic acids (NAs) in wastewater is necessary due to its high toxicity and difficult degradation. In the heterogeneous Fenton-like advanced oxidation of organic pollutant system, the insufficient accessibility of oxidizing agent and NAs greatly hamper the reaction efficiency. CO-responsive phase transfer materials derived from polyethylene glycol (PEG)-based deep eutectic solvents were specific targeted at the immiscible-binary phase system.

Dynamic event-triggered consensus control for nonlinear multi-agent systems under DoS attacks.

In this paper, we investigated leader-following consensus control for nonlinear multi-agent systems (MASs) experiencing denial-of-service (DoS) attacks. We proposed a distributed control strategy incorporating an adaptive scheme and a state feedback control gain to eliminate the effects of system nonlinear dynamics and uncertainties. In addition, we introduced a dynamic event-triggered control (DETC) to minimize the utilization of communication resources.

Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4.

Unlabelled: Vaccinia virus (VACV) is a large DNA virus that encodes scores of proteins that modulate the host immune response. VACV protein C4 is one such immunomodulator known to inhibit the activation of both the NF-κB signaling cascade and the DNA-PK-mediated DNA sensing pathway. Here, we show that the N-terminal region of C4, which neither inhibits NF-κB nor mediates interaction with DNA-PK, still contributes to virus virulence.

Distributed Dynamic Event-Triggered Control to Leader-Following Consensus of Nonlinear Multi-Agent Systems with Directed Graphs.

This paper investigates achieving leader-following consensus in a class of multi-agent systems with nonlinear dynamics. Initially, it introduces a dynamic event-triggered strategy designed to effectively alleviate the strain on the system's communication resources. Subsequently, a distributed control strategy is proposed and implemented in the nonlinear leader-follower system using the dynamic event-triggered mechanism, aiming to ensure synchronization across all nodes at an exponential convergence speed.

The predictive value of sarcopenia and myosteatosis in trans-arterial (chemo)-embolization treated HCC patients.

Background: We conducted a meta-analysis to provide evidence-based results for the predictive values of sarcopenia, skeletal muscle index, psoas muscle index and the myosteatosis regarding the impact of survival outcomes and tumor response in patients treated by trans-arterial (chemo)-embolization (TAE/TACE), thereby optimizing therapeutic strategies and maximizing clinical benefits for hepatocellular carcinoma patients.

Methods: Qualified studies were retrieved from PubMed, the Cochrane Library, EMBASE, and Google Scholar before June 19, 2023. We investigated the relationships between sarcopenia, SMI, PMI, myosteatosis, and the overall survival of TAE/TACE-treated hepatocellular carcinoma patients with pooling data.

Bronchial balloon dilatation combined with cryotherapy for tuberculous cicatricial central airway stenosis, with Adobe Photoshop for the degree measurement: A multicenter, retrospective study.

Objective: To explore bronchial balloon dilation (BD) combined with cryotherapy and Photoshop (PS)-base image processing technology in the interventional treatment of tuberculous cicatricial central airway stenosis (CCAS).

Methods: This multicenter, retrospective study analyzed the clinical data of patients with CCAS from six hospitals in Henan, China between June 2019 and October 2022.

Results: A total of 307 patients were included, including 152 (62 males) treated with BD alone and 155 (54 males) treated with BD combined with cryotherapy.

Value of radiomics in differentiating synchronous double primary lung adenocarcinomas from intrapulmonary metastasis.

Background: Distinguishing synchronous double primary lung adenocarcinoma (SDPLA) from intrapulmonary metastasis (IPM) of lung cancer has significant therapeutic and prognostic values. This study aimed to develop and validate a CT-based radiomics model to differentiate SDPLA from IPM.

Methods: A total of 153 patients (93 SDPLA and 60 IPM) with 306 pathologically confirmed lesions were retrospectively studied.

Moyamoya disease with distal anterior choroidal artery aneurysm resected via transcallosal approach: A case report and review.

Rationale: Moyamoya disease (MMD) is a cerebrovascular structural disorder characterized by bilateral stenosis and obstruction of the internal carotid artery, anterior cerebral artery, and initial segment of a middle cerebral artery, as well as the aberrant formation of collateral arteries at the base of the brain. Moyamoya disease with distal anterior choroidal artery (AChA) aneurysm is extremely uncommon. At present, the treatment of Moyamoya disease with aneurysm mainly includes conservative treatment and surgical treatment, including revascularization, endovascular therapy and microsurgical clipping or resection.

Mechanistic insights into the lignin dissolution behavior in amino acid based deep eutectic solvents.

Deep eutectic solvents (DESs) composed by amino acids (L-arginine, L-proline, L-alanine) as the hydrogen bond acceptors (HBAs) and carboxylic acids (formic acid, acetic acid, lactic acid, levulinic acid) as hydrogen bond donors (HBDs) were prepared and used for the dissolution of dealkaline lignin (DAL). The mechanism of lignin dissolution in DESs was explored at molecular level by combining the analysis of Kamlet-Taft (K-T) solvatochromic parameters, FTIR spectrum and density functional theory (DFT) calculations of DESs. Firstly, it was found that the formation of new hydrogen bonds between lignin and DESs mainly drove the dissolution of lignin, which were accompanied by the erosion of hydrogen bond networks in both lignin and DESs.

Quantitative detection of naphthenic acids in wastewater based on superior fluorescence performance of nitrogen-rich carbon quantum dots.

With the development of the petrochemical industry, a large amount of naphthenic acids in petrochemical wastewater was accumulated in the environment, causing serious environmental pollution. Most of the commonly used methods for the determination of naphthenic acids have the characteristics of high energy consumption, complicated pretreatment, long detection cycle, and the need to send samples to analytical laboratories. Therefore, it is essential to develop an efficient and low-cost field analytical method for rapidly naphthenic acids quantify.

CAR-iNKT cells targeting clonal TCRVβ chains as a precise strategy to treat T cell lymphoma.

Introduction: Most T cell receptor (TCR)Vβ chain-expressing T cell lymphomas (TCL) including those caused by Human T cell leukaemia virus type-1 (HTLV-1) have poor prognosis. We hypothesised that chimeric antigen receptor (CAR)-mediated targeting of the clonal, lymphoma-associated TCRβ chains would comprise an effective cell therapy for TCL that would minimally impact the physiological TCR repertoire.

Methods: As proof of concept, we generated CAR constructs to target four TCRVβ subunits.

Preparation of carbon quantum dots from ionic liquid modified biomass for the detection of Fe and Pd in environmental water.

A new type of green carbon quantum dots (ILB-CQDs) was prepared by hydrothermal method using ionic liquid as a modifier and grape skin as carbon source, and was obtained from hydrogen-bonded lattice structure ionic liquid preparation, which makes the CQDs in a ring-like stable structure with a stability period of more than 90 day. There is also the catalytic effect of the ionic liquid on cellulose, which makes the prepared CQDs show good advantages, such as uniform particle size, high quantum yield (26.7%), and very good fluorescence performance.

overexpression accumulates coumarin secondary metabolites in transgenic .

Unlabelled: The dried root of is a traditional Chinese herbal medicine mainly used to treat lung diseases and plays an important role in fighting coronavirus disease 2019 pneumonia in China. This study focused on the key enzyme gene for furanocoumarin synthesis in . In the 35S: transgenic study, the -overexpressing gene was more salt-tolerant than in the blank group.

Vaccinia virus BTB-Kelch proteins C2 and F3 inhibit NF-κB activation.

Vaccinia virus (VACV) encodes scores of proteins that suppress host innate immunity and many of these target intracellular signalling pathways leading to activation of inflammation. The transcription factor NF-κB plays a critical role in the host response to infection and is targeted by many viruses, including VACV that encodes 12 NF-κB inhibitors that interfere at different stages in this signalling pathway. Here we report that VACV proteins C2 and F3 are additional inhibitors of this pathway.

Abnormal degree centrality values as a potential imaging biomarker for major depressive disorder: A resting-state functional magnetic resonance imaging study and support vector machine analysis.

Objective: Previous studies have revealed abnormal degree centrality (DC) in the structural and functional networks in the brains of patients with major depressive disorder (MDD). There are no existing reports on the DC analysis method combined with the support vector machine (SVM) to distinguish patients with MDD from healthy controls (HCs). Here, the researchers elucidated the variations in DC values in brain regions of MDD patients and provided imaging bases for clinical diagnosis.