Coastal ecosystems are increasingly threatened by nutrient imbalances and environmental degradation, which can compromise their stability and productivity. We analyzed the sediment characteristics, microbial community structures, and nutrient cycling across three habitats: mangrove forests, seagrass beds, and bare beaches. The physicochemical properties (including pH, total nitrogen (TN), phosphorus (P), and potassium (K)) of the sediment samples were analyzed, and the microbial diversity was assessed using high-throughput sequencing.
View Article and Find Full Text PDFWiley Interdiscip Rev Nanomed Nanobiotechnol
December 2024
In recent years, the diagnosis and treatment at the early stages significantly raise the survival rate of breast cancer patients. Moreover, antibody drugs pave the way toward precision target therapy. However, the treatment and survival of triple-negative breast cancer (TNBC) patients is still worrying, which needs further understanding and study.
View Article and Find Full Text PDFBackground: Dietary fibre can alleviate or reduce the risk of obesity and obesity-induced abnormalities in glycolipid metabolism. However, the effects of different types of dietary fibre or their combinations on obesity remain unclear. Here, we explored the effects of different ratios of inulin soluble dietary fibre (ISDF) and barley leaf insoluble dietary fibre (BLIDF) on the body weight, glycolipid metabolism and gut microbiota of obese mice.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
January 2025
Current surface modification strategies for electrospun materials always require covalent conjugation technology, which is relatively inefficient and might damage the bioactivity and structure of peptides and proteins. Here we introduce the use of surface-induced self-assembly technology to modify electrospun materials, which is a simple but efficient noncovalent-based process. Results show that the peptide NapFFGRGD forms burr-like structures on the surface of PCL fibers, reducing the water contact angle of the fibers.
View Article and Find Full Text PDFThe emergence of multidrug-resistant isolates is a growing concern for public health, necessitating new therapeutic strategies. Gallium nitrate [Ga(NO)], a medication for cancer-related hypercalcemia, has attracted great attention due to its ability to inhibit growth and biofilm formation by disrupting iron metabolism. However, the antibacterial efficacy of Ga(NO) is not always satisfactory.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
September 2024
This study aims to investigate the effects of Linggui Zhugan Decoction(LGZGD) on myocardial fibrosis(MF) and the Lats1/Yap signaling pathway in mice after myocardial infarction(MI), exploring its role and mechanism in inhibiting MF. The MI-induced ischemic mouse model was established by left anterior descending coronary artery ligation, followed by continuous intervention for six weeks. Doppler ultrasound imaging-system of small animals was used to detect left ventricular ejection fraction(LVEF), left ventricular fractional shortening(LVFS), left ventricular internal diameter at end-systole(LVIDs), and left ventricular internal diameter at end-diastole(LVIDd).
View Article and Find Full Text PDFObjectives: This study aims to develop a robust predictive model for survival in AML patients undergoing allo-HSCT.
Methods: It was performed a retrospective analysis of 336 AML patients who underwent allo-HSCT at Peking University First Hospital between September 2003 and March 2023. Univariable and multivariable Cox regression analyses were conducted to determine hazard ratios (HR) for overall survival.
IEEE Trans Neural Netw Learn Syst
September 2024
The transbronchial interventional surgery presents challenges with winding and convoluted pathways, prone to compression and friction. Current autonomous planning struggles to reach deeper bronchial positions, and hard to consider multiple conflicting goals simultaneously. This article introduces an innovative planning scheme with preference weights to achieve smooth, frictionless, and collision-free autonomous transbronchial intervention with continuum robot (CR).
View Article and Find Full Text PDFPiwi-interacting RNA (piRNA) is a type of non-coding small RNA that is highly expressed in mammalian testis. PiRNA has been implicated in various human diseases, but the experimental validation of piRNA-disease associations is costly and time-consuming. In this article, a novel computational method for predicting piRNA-disease associations using a multi-channel graph variational autoencoder (MC-GVAE) is proposed.
View Article and Find Full Text PDFTraining with soft labels instead of hard labels can effectively improve the robustness and generalization of deep learning models. Label smoothing often provides uniformly distributed soft labels during the training process, whereas it does not take the semantic difference of labels into account. This article introduces discrimination-aware label smoothing, an adaptive label smoothing approach that learns appropriate distributions of labels for iterative optimization objectives.
View Article and Find Full Text PDFShape-shifting polymers are widely used in various fields such as intelligent switches, soft robots and sensors, which require both multiple stimulus-response functions and qualified mechanical strength. In this study, a novel near-infrared-light (NIR)-responsible shape-shifting hydrogel system was designed and fabricated through embedding vinylsilane-modified carbon nanotubes (CNTs) into particle double-network (P-DN) hydrogels by micellar copolymerisation. The dispersed brittle Poly(sodium 2-acrylamido-2-methylpropane-1-sulfonate) (PNaAMPS) network of the microgels can serve as sacrificial bonds to toughen the hydrogels, and the CNTs endow it with NIR photothermal conversion ability.
View Article and Find Full Text PDFShape-shifting polymers usually require not only reversible stimuli-responsive ability, but also strong mechanical properties. A novel shape-shifting photochromic hydrogel system was designed and fabricated by embedding hydrophobic spiropyran (SP) into double polymeric network (DN) through micellar copolymerisation. Here, sodium alginate (Alg) and poly acrylate-co-methyl acrylate-co-spiropyran (P(SA--MA--SPMA)) were employed as the first network and the second network, respectively, to realise high mechanical strength.
View Article and Find Full Text PDFLysophosphoglycerides (LPLs) have been reported to accumulate in myocardium and serve as a cause of arrhythmias in acute myocardial ischemia. However, in this study we found that LPLs level in the ventricular myocardium was decreased by the onset of acute myocardial ischemia in vivo in rats. Decreasing of LPLs level in left ventricular myocardium, but not right, was observed within 26 min of left myocardial ischemia, regardless of whether arrhythmias were triggered.
View Article and Find Full Text PDFComput Struct Biotechnol J
December 2024
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs (ncRNAs) that plays important roles in many biological processes and major cancer diagnosis and treatment, thus becoming a hot research topic. This study aims to provide an in-depth review of computational piRNA-related research, including databases and computational models. Herein, we perform literature analysis and use comparative evaluation methods to summarize and analyze three aspects of computational piRNA-related research: (i) computational models for piRNA-related molecular identification tasks, (ii) computational models for piRNA-disease association prediction tasks, and (iii) computational resources and evaluation metrics for these tasks.
View Article and Find Full Text PDFPersimmons ( Thunb.) have a longstanding history of cultivation in China. Both aesthetically pleasing and edible, they often symbolize a sweet and fulfilling life.
View Article and Find Full Text PDFBackground: Several studies have reported that the mountain climate can alleviate asthma, however, the effect of tropical climate on migratory elderly, especially in people with respiratory or allergic diseases is unknown.
Objectives: This cohort study aims to explore impact of climate and environmental changes on allergic diseases in migratory old people.
Methods: In this prospective cohort study, we recruited 750 older migratory people, the majority of whom were homeowners to minimize the risk of loss to follow up.
Front Public Health
November 2023
Profound progress has been made in cancer treatment in the past three decades. However, drug resistance remains prevalent and a critical challenge. Drug resistance can be attributed to oncogenes mutations, activated defensive mechanisms, ATP-bind cassette transporters overexpression, cancer stem cells, Chinese traditional medicine toad venom has been used for centuries for different diseases, including resistant cancers.
View Article and Find Full Text PDFApple leaf diseases without timely control will affect fruit quality and yield, intelligent detection of apple leaf diseases was especially important. So this paper mainly focuses on apple leaf disease detection problem, proposes a machine vision algorithm model for fast apple leaf disease detection called LALNet (High-speed apple leaf network). First, an efficient sacked module for apple leaf detection, known as EALD (efficient apple leaf detection stacking module), was designed by utilizing the multi-branch structure and depth-separable modules.
View Article and Find Full Text PDFAdsorption of polymers on clay in aqueous solutions has wide applications in environmental, medical, and energy-related areas, but the interactions between polymers and clay under varied conditions are still not fully understood. In this study, we investigated the adsorption mechanisms of four polymers belonging to different categories, namely anionic poly(acrylic acid) (poly-AA), cationic poly(diallyldimethylammonium chloride) (poly-DADMAC), nonionic polyacrylamide (poly-AM), and the copolymer of AA and DADMAC (poly-AADADMAC). By using molecular dynamics simulations, we compared the desorption kinetics of these polymers at different temperatures and found that poly-AA and poly-AM have the weakest and strongest adsorption abilities, respectively.
View Article and Find Full Text PDFWith the exploration and development of high-temperature and high-salt deep oil and gas, more rigorous requirements are warranted for the performance of water-based drilling fluids (WBDFs). In this study, acrylamide, 2-acrylamide-2-methylpropanesulfonic acid, diallyl dimethyl ammonium chloride, and N-vinylpyrrolidone were synthesized by free radical copolymerization in an aqueous solution to form a temperature and salt-resistant zwitterionic polymer gel filtration loss reducer (AADN). The zwitterionic polymer had excellent adsorption and hydration groups, which could effectively combine with bentonite through hydrogen bonds and electrostatic attraction, strengthening the hydration film thickness on the surface of bentonite, and promoting the stable dispersion of drilling fluid.
View Article and Find Full Text PDFNatural gels are emerging as a hotspot of global research for their greenness, environmental-friendliness, and good hydrate inhibition performance. However, previous studies mostly performed experiments for simple pure water systems and the inhibition mechanism in the sediment environment remains unclear. Given this, the inhibition performance of xanthan gum and pectin on hydrate nucleation and growth in sediment environments was evaluated via hydrate formation inhibition tests, and the inhibition internal mechanisms were revealed via a comprehensive analysis integrating various methods.
View Article and Find Full Text PDFTo control the filtration loss of drilling fluids in salt-gypsum formations, a novel type of zwitterionic polymer gel (DNDAP) was synthesized by free radical polymerization, which was used as a salt- and calcium-resistant fluid loss reducer for water-based drilling fluids (WBDF). DNDAP was prepared with N, N-dimethylacrylamide (DMAA), N-vinylpyrrolidone (NVP), Diallyl dimethyl ammonium chloride (DMDAAC), 2-acrylamide-2-methylpropaneonic acid (AMPS), and isopentenol polyether (TPEG) as raw materials. Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance (H-NMR) were used to characterize the composition and structure of the DNDAP copolymer.
View Article and Find Full Text PDFCaCO filler masterbatch (CFM) is one of the most commonly used fillers in polypropylene (PP) and polyethylene (PE) products, and its is used to enhance the toughness of the polymer matrix. This is the first study to investigate the loss of CaCO and its impact on the adsorption ability of microplastics from plastic woven bags throughout the natural aging process. PP wire (PPw, 85% PP + 15% CFM) and PE film (PEf, 80% PE + 20% CFM) samples from plastic woven bags underwent a 250 d aging process in an open-air environment.
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