Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5.

Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of malignant tumors in adults, while clear cell renal cell carcinoma accounts for 70-85% of kidney cancer cases, with an increasing incidence worldwide. G9a is the second histone methyltransferase found in mammals, catalyzing lysine and histone methylation. It regulates gene transcription by catalyzing histone methylation and interacting with transcription factors to alter the tightness of histone-DNA binding.

Comparison of Intraperitoneal and Intratesticular GYY4137 Therapy for the Treatment of Testicular Ischemia Reperfusion Injury in Rats.

The efficacy of intraperitoneal GYY4137 therapy and intratesticular GYY4137 therapy in an experimental rat model was investigated. Four groups were set up as the sham-operation group, torsion/detorsion (T/D) group, T/D plus intraperitoneal GYY4137 (G-IP) group, and T/D plus intratesticular GYY4137 (G-IT) group. In order to establish a testicular T/D model, the left testis was operated and the rotation reached 720° clockwise which lasted 1 h before reperfusion.

[Whole genome sequencing reveals the distribution of resistance and virulence genes of pathogenic CCHTP from giant panda].

Pathogenic is the most common pathogen causing urinary tract infection in animals. We investigated the antibiotic resistance and virulence genes of pathogenic CCHTP derived from urine with occult blood of the giant panda by whole genome sequencing. The flanking sequencing of resistance and virulence genes in genomic islands were also analyzed.

Improving Species Identification of Ancient Mammals Based on Next-Generation Sequencing Data.

The taxonomical identification merely based on morphology is often difficult for ancient remains. Therefore, universal or specific PCR amplification followed by sequencing and BLAST (basic local alignment search tool) search has become the most frequently used genetic-based method for the species identification of biological samples, including ancient remains. However, it is challenging for these methods to process extremely ancient samples with severe DNA fragmentation and contamination.

A deep study of the protection of Lithium Cobalt Oxide with polymer surface modification at 4.5 V high voltage.

Charging the cells above a conventional voltage of 4.2 V is a promising attempt to increase the energy density of Lithium Cobalt Oxide (LCO), however, the problem of crystal instability at high voltage that leading deterioration of cycle performance needs to be urgently resolved. In this work, as an effective and easy approach to improve the cycle performance and crystal stability of LCO cycling at 4.

[Effects of wilderness-training Ailuropoda melanoleuca's feeding and artificial harvesting on population structure of Fargesia robusta clone].

From 2003 to 2007, the methods of plot sampling and positioning observation were adopted to investigate the population density, basal diameter, and plant height of Umbrella bamboo (Fargesia robusta) clone in the Wolong Natural Reserve of China. In the meantime, the effects of wilderness-training Ailuropoda melanoleuca's feeding and artificial harvesting on the population regeneration of the clone were studied, and the responses of the population structure (age-, size-, and height-class distribution) to different management modes (A. melanoleuca's feeding, artificial harvesting, control) were approached with the scale- and shape-parameters of Weibull distribution function.