Rutin ameliorates calcium oxalate crystal-induced kidney injury through anti-oxidative stress and modulation of intestinal flora.

Kidney stones are a common urological disease. Although there are many ways to treat them, their high recurrence rate remains unresolved. Research has demonstrated that Lysimachia christinae Hance influences kidney stone development; however, the exact mechanism remains unclear.

Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD).

This review explores the therapeutic potential of resveratrol, focusing on its molecular and cellular effects on Chronic Obstructive Pulmonary Disease (COPD), bioavailability enhancement strategies, and development challenges for applications in food, pharmaceuticals, and postharvest sectors. Resveratrol protects lungs by activating SIRT1, reducing oxidative stress via ROS regulation through Nrf2-mediated antioxidant enzymes. It shows promise as an alternative to corticosteroids in COPD and cancer treatment.

Integrated immunological analysis of single-cell and bulky tissue transcriptomes reveals the role of prognostic value of T cell-related genes in cervical cancer.

The relationship between cervical cancer (CESC) and T cells is mainly seen in the anti-tumor functions of T cells. This study aims to identify prognostic genes associated with CESC and T cells, providing a foundation for developing immunotherapy strategies. This study used data from public databases to identify T cell-related prognostic genes for CESC patients through differential expression analysis and single-cell clustering.

The Role of Chemokine (C-C Motif) Ligand 7 (CCL7) in Hepatocellular Carcinoma: Expression, Function, and Mechanisms.

Aim: AHepatocellular carcinoma (HCC) is a malignant neoplasm characterized by a poor prognosis, with its incidence rising globally. Chemokine (C-C motif) ligand 7 (CCL7), a chemokine protein, has been implicated in the progression of various cancers. Nonetheless, the specific role of CCL7 in HCC has yet to be elucidated.

Right Aortic Arch With Kommerell Diverticulum and a Rare Type of Isolated Left Subclavian Artery.

The isolated left subclavian artery is a rare congenital variation of the vascular structure. Herein, we report the case of a 10-year-old boy with a rare isolated left subclavian artery. The left subclavian artery evolved from stenosis to atresia, resulting in subclavian steal syndrome.

Filling the Gaps: Tracing 12 Types of Non-commodity Plastics in China's Plastic Socioeconomic Metabolism.

Recent plastic flow research has largely focused on commodity plastics (PE, PP, PVC, PS, ABS), yet a sizable share of other polymer types remains understudied. These non-commodity plastics suffer from inconsistent definitions, complex classifications, and data gaps, which hinder accurate assessment of their production, use, and end-of-life management. This study develops dynamic material flow analysis to investigate 12 key "non-commodity" plastics in China─including PET, PU, seven engineering plastics, and three thermosetting plastics─and addresses these knowledge gaps.

Construction of a user-friendly software-defined networking management using a graph-based abstraction layer.

The software-defined networking (SDN) paradigm relies on the decoupling of the control plane and data plane. Northbound interfaces enable the implementation of network services through logical centralised control. Suitable northbound interfaces and application-oriented abstractions are the core of the SDN ecosystem.

Association of ANA and SSA autoantibodies with progression-free survival in multiple myeloma: a retrospective cohort study.

Objective: This study aimed to investigate the relationship between autoantibodies, specifically Antinuclear Antibody (ANA) and anti-Sjögren's-syndrome-related antigen A (SSA), and progression-free survival (PFS) in multiple myeloma (MM) patients.

Methods: A retrospective cohort study was conducted on 304 MM patients diagnosed between 2010 and 2020 at Shanghai Changzheng Hospital, with follow-up until October 2023. Patients were stratified based on ANA and SSA positivity.

Cohort Profile: TRacing Etiology of Non-communicable Diseases (TREND): Rationale, Progress and Perspective.

Unlabelled: The TRacing Etiology of Non-communicable Diseases (TREND) cohort is a prospective longitudinal cohort and biobank that is mainly based in Ma'anshan, Anhui Province, China. The primary aim of the study is to decipher comprehensive molecular characterization and deep phenotyping for a broad spectrum of chronic non-communicable diseases (NCDs), which focuses on providing mechanistic insights with diagnostic, prognostic and therapeutic implications. The recruitment was initiated in 2023 and is expected to complete in 2025 with 20,000 participants originated from urban and rural area.

Crop Wild Relatives (CWRs) in the United Arab Emirates: Resources for Climate Resilience and Their Potential Medicinal Applications.

Global climate change threatens the production, growth, and sustainability of plants. Crop wild relatives (CWRs) offer a practical and sustainable solution to these climatic issues by boosting genetic diversity and crop resilience. Even though CWRs are wild relatives of domesticated plants, they are nevertheless mostly neglected.

Shortening the recipient warm ischemia time could be a strategy for expanding the liver donor pool.

Background: Shortening the recipient warm ischemia time (rWIT) has been proven to be effective for improving the short- and long-term outcomes after liver transplantation (LT) and offsets the negative impact of an extended cold ischemia time. However, few studies have been conducted to explore the prognostic effects of shortening the rWIT in transplantations using a liver graft from an extended-criteria donor (ECD).

Aim: To investigate whether shortening the rWIT could improve the outcomes of ECD LT.

The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.

Background: Macrophages are highly plastic cells, and macrophage-derived exosomes (M-Exos) have been implicated in inflammation-related pathophysiologies, such as tissue injury and fibrosis repair. This study aimed to investigate the possible effects of M-Exos on the initiation and development of urethral fibrosis and stricture after injury, and to elucidate the underlying mechanisms.

Methods: In this study, we used time-tracking immunofluorescence staining for M1 and M2 macrophage markers to characterize sequential properties in the site of injured urethra.

Evaluating the predictive value of clinical models for HBV-related hepatocellular carcinoma: A meta-analysis.

Objectives: Chronic viral hepatitis B (CHB) is a prevalent liver disease with primary hepatic carcinoma (HCC) as a severe complication. Clinical prediction models have gained attention for predicting HBV-related HCC (HBV-HCC). This study aimed to evaluate the predictive value of existing models for HBV-HCC through meta-analysis.

Clinical patterns in a neuroimaging-based predictive model of self-reported dissociation.

Objective: Assessment of trauma-related dissociation has been historically challenging given its subjective nature and the lack of provider education around this topic. Recent work identified a promising neural biomarker of trauma-related dissociation, representing a significant step toward improved assessment and identification of dissociation. However, it is necessary to better understand clinical factors that may be associated with this biomarker.

Effect of adipose-derived stem cells exosomes cross-linked chitosan-αβ-glycerophosphate thermosensitive hydrogel on deep burn wounds.

Background: Burn wound management is challenging, and while mesenchymal stem cell-derived exosomes show therapeutic potential, optimal delivery methods are unclear.

Aim: To study chitosan (CS)-αβ-glycerophosphate (CS-αβ-GP) hydrogel crosslinked with adipose-derived stem cell exosomes (ASC-Exos) for healing deep burn injuries.

Methods: Rats with deep burn injuries were divided into the CS + ASCs-Exos group, the ASCs-Exos group, the CS group, and the control group.

Corrigendum: Correlation between CT-derived fractional flow reserve and myocardial strain in ischemic heart disease patients with single coronary artery stenosis assessed based on CCTA.

[This corrects the article DOI: 10.3389/fcvm.2025.

Membrane modification strategies for virus removal from water.

Membrane technology, through innovative approaches such as nanocomposite membranes, membrane bioreactors, and electrocatalytic membrane reactors, offers a synergistic platform for pathogen removal. This review examines recent advancements in membrane modifications aimed at optimizing virus removal efficiency. It outlines various mechanisms employed in these innovations, including size exclusion, electronic interactions, hydrophobic and hydrophilic interactions, and pathogen inactivation.

Evolution of the Pore-Fracture System of Coal: A Case Study of Zhaozhuang Colliery, Qinshui Basin.

The structure and evolution of coal are intricately linked to its properties at both nanometer and micrometer scales. The refinement of pores and fractures is crucial for assessing outburst risks, evaluating coalbed methane (CBM) reservoirs, and improving the CBM recovery efficiency. This study involved collecting four different coal-body structure samples from the Zhaozhuang colliery in the southern Qinshui Basin.

Effectiveness Evaluation on Network Fracturing in Ultra-Deep and Extremely Thick Reservoirs in Kuqa Piedmont-A Case Study of Well KS2-A.

In the Keshen Gas Field in Kuqa Piedmont, the Cretaceous Bashijiqike formation is the main producing layer. The deepest exploratory wells exceed 8000 m, with reservoir pressures reaching 150 MPa, temperatures peaking at 190 °C, and formation thicknesses ranging from 100 to 300 m. The extreme operating conditions and well-controlled risks limit the testing methods after stimulation.

Mixture Effects of Polystyrene Microplastics on the Gut Microbiota in C57BL/6 Mice.

Microplastics are plastic particles with sizes of less than 5 mm. The ubiquity of microplastics in the environment has raised serious public health concerns. Microplastics could disturb the composition of the gut microbiota due to both chemical composition and physical interactions, which might further influence the metabolism and immune function of the host.

Activity of human-specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X Syndrome.

Astrocytes, a type of glial cells, have multiple roles in regulating neuronal development and homeostasis. In addition to the typical mammalian astrocytes, in the primate cortex interlaminar astrocytes are located in the superficial layer and project long processes traversing multiple layers of the cerebral cortex. Previously, we described a human stem cell based chimeric mouse model where interlaminar astrocytes develop.

Linear dicentric chromosomes in bacterial natural isolates reveal common constraints for replicon fusion.

Unlabelled: Multipartite bacterial genome organization can confer advantages including coordinated gene regulation and faster genome replication but is challenging to maintain. lineages often contain a circular chromosome (Ch1), a linear chromosome (Ch2), and multiple plasmids. We previously observed that in some stocks of the lab model strain C58, Ch1 and Ch2 were fused into a linear dicentric chromosome.

Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion Machinery.

Loop-extrusion machinery, comprising the cohesin complex and CCCTC-binding factor CTCF, organizes the interphase chromosomes into topologically associating domains (TADs) and loops, but acute depletion of components of this machinery results in variable transcriptional changes in different cell types, highlighting the complex relationship between chromatin organization and gene regulation. Here, we systematically investigated the role of 3D genome architecture in gene regulation in mouse embryonic stem cells under various perturbation conditions. We found that acute depletion of cohesin or CTCF disrupts the formation of TADs, but affects gene regulation in a gene-specific and context-dependent manner.

AggreBots: configuring CiliaBots through guided, modular tissue aggregation.

Ciliated biobots, or CiliaBots, are a class of engineered multicellular tissues that are capable of self-actuated motility propelled by the motile cilia located on their exterior surface. Correlations have been observed between CiliaBot motility patterns and their morphology and cilia distribution. However, precise control of these structural parameters to generate desired motility patterns predictably remains lacking.

Study on the pharmacodynamics and related mechanism of Tangningtongluo tablet on prediabetes mice based on the theory of "liver controlling dispersion".

Background And Aim: Prediabetes is an unavoidable process and a high risk factor for developing of type 2 diabetes. Tangningtongluo (TNTL) tablet is a kind of pure plant preparation in hospital and used for the diabetes (, xiāo kě bìng) caused by deficiency of both Qi and Yin (，qì yīn liǎng xū). However, the effect of TNTL tablet on prediabetes has not been reported for now.