Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors.

To evaluate the comparative efficacy of Ticagrelor and Clopidogrel in treating patients with coronary heart disease and unstable angina, as well as their effects on serum inflammatory factors, thereby providing a solid foundation for future clinical diagnosis and treatment. The frequency of angina attacks in the Ticagrelor group was lower than in the Clopidogrel group (P<0.05).

PLZF-expressing CD4 T cells promote tissue-resident memory T cells in breaking immune tolerance in allergic asthma via IL-15/IL-15Rα signaling.

Background: Allergic asthma is a chronic airway disease characterized by an allergic response and altered immune tolerance. CD4 tissue-resident memory T (TRM) cells are crucial in the chronic and relapsing pathogenesis of asthma. Furthermore, promyelocytic leukemia zinc finger (PLZF) is an essential transcription factor involved in asthmatic tolerance and has been implicated in the regulation of CD4CD44 memory T cells.

Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study.

Objective: To evaluate the association between the LHCGR rs2293275 (N312S) genotype and ovarian aging phenotypes in Han Chinese women, focusing on diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI).

Study Design: This multicenter population-based study included 1,240 women aged 18-40 years diagnosed with DOR (n = 711) or POI (n = 529), alongside 72,846 ethnically and regionally matched controls from the Han Chinese Genomes Database (PGG.Han).

Genome-wide exploration and characterization of the RALFs and analysis of its role in peanut (Arachis hypogaea L.).

Background: Rapid alkalinization factors (RALFs) are small peptides hormones that regulate plant growth and stress responses. Although RALFs have been identified in a broad range of land plant species, their roles in peanuts (Arachis hypogaea L.) remain largely unexplored.

Identification and validation of a major QTL, QFhb-6AL, for Fusarium head blight resistance on chromosome 6AL in wheat.

A novel major QTL, QFhb-6AL, accounting for 34.6% phenotypic variation for FHB resistance, was identified in the Chinese cultivar Xunong 029, and a near-diagnostic marker was developed for marker-assisted selection. Fusarium head blight (FHB) is a destructive disease in wheat (Triticum aestivum L.

A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat.

Fusarium crown rot (FCR) is a serious underlying disease to threaten wheat yield and quality recently. Here, we identify a catalase antioxidant enzyme (TaCAT2) through genome wide association study (GWAS) and whole-exome sequencing (WES) in two nested bi-parental populations. We verify the function of TaCAT2 regulating wheat FCR resistance by genetic transformation.

Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.

Previous studies have demonstrated that silica can activate the NLRP3 inflammasome, and that macrophage phagocytosis is an essential step in this process. Although carbon is the primary component of coal dust particles, it also contains other impurities such as free silica, clay, sulfides, and carbonate minerals. Additional research is still necessary to discover if NLRP3 can be triggered due to the low silica content of coal dust particles.

Thyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis.

Multiple sclerosis (MS) is a prevalent neurological disorder with a complex etiology, often associated with thyroid function. However, the causal relationship between these two conditions remains poorly understood. This study aimed to elucidate the causal relationship between thyroid function and MS using a bidirectional Mendelian randomization (MR) approach and to investigate the potential mediating role of immune cells.

Core N-DRC components play a crucial role in embryonic development and postnatal organ development.

Motile cilia and flagella are evolutionarily conserved organelles, and their defects cause primary ciliary dyskinesia (PCD), a disorder characterized by systemic organ dysfunction. The nexin-dynein regulatory complex (N-DRC) is a crucial structural component of motile cilia and flagella, present across various species from Chlamydomonas to humans. Defects in N-DRC components lead to multiple PCD symptoms, including sinusitis and male infertility.

IRE1α/TRAF2/NF-κB pathway promotes apoptosis via regulating inflammatory cytokines and aggravates brain injury after SAH.

Objectives: To investigate the effect of IRE1α/TRAF2/NF-κB pathway on early brain injury.

Methods: An endovascular puncture model of subarachnoid hemorrhage (SAH) was developed and SAH grading was performed. The following groups of experimental animals were randomly assigned: Blank group, Sham group, SAH+ DMSO group, SAH+STF-083010(IRE1α inhibitor) group, and SAH+BAY11-7082(NF-κB inhibitor) group.

Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway.

Bisphenol AF (BPAF), one of the most common bisphenol analogues, has been reported to exhibit higher estrogenic activity compared to bisphenol A (BPA) due to the presence of additional hydrophobic groups. To comprehensively understand the male reproductive toxicity of BPAF, TM3 Leydig cells were used to investigate the effects of BPAF on cell proliferation, apoptosis, and cell cycle arrest. The underlying mechanisms of cellular responses induced by BPAF were examined through analysis of target mRNA and protein expression.

Reevaluating the Role of Pou3f1 in Striatal Development: Evidence from Transgenic Mouse Models.

The striatum, a critical component of the basal ganglia, is essential for motor control, cognitive processing, and emotional regulation. Medium spiny neurons (MSNs) are the primary neuronal population in the striatum, classified into D1 and D2 subtypes. The transcription factor Pou3f1 has been hypothesized to play a crucial role in the development of pyramidal neurons.

Associations between major depressive disorders and Parkinson's Disease and impact of their comorbidity sequence.

Background: The comorbidity of major depressive disorder (MDD) and Parkinson's disease (PD) were prevalent and has a profound impact on patients. However, whether this comorbidity results from specific pathological processes or a mutual cause-and-effect relationship was largely controversial. Additionally, although MDD can appear before or after PD, the health impact of the comorbidity sequence is poorly understood.

Apigenin attenuated sepsis induced acute lung injury via polarizing macrophage towards M2 by blocking miR-146a →TLR7 interaction.

TLR7 (Toll-like receptor 7) has been indicated as an important sensor for single -stranded RNA contributes to systemic inflammation and mortality in acute lung injury (ALI), which is an acute diffuse inflammatory lung injury. Cumulative results show that macrophages contribute to the development and progression of ALI through the secretion of inflammatory cytokines/chemokines. Here we show that macrophage polarizes towards M1 phenotype and TLR7 signaling is activated in septic mice.

Bacillus licheniformis and Wickerhamiella versatilis: Sources of the pleasant smoky and fruity flavors of soybean paste.

4-Vinylguaiacol (4-VG) and 4-Ethylguaiacol (4-EG) are key aromatic compounds that contribute to the characteristic smoky and soy-like aromas of soybean paste, thereby influencing its overall flavor. 4-EG in soybean paste reached 13.76 mg/kg through the inoculation of two bacterial strains: Bacillus licheniformis, which promotes the production of 4-VG, and Wickerhamiella versatilis, which enhances the generation of 4-EG.

Naturally inspired chimeric quinolone derivatives to reverse bacterial drug resistance.

Antimicrobial resistance poses an urgent threat to global health, underscoring the critical need for new antibacterial drugs. Ciprofloxacin, a third-generation quinolone antibiotic, is used to treat different types of bacterial infections; however, it often results in the rapid emergence of resistance in clinical settings. Inspired by low susceptibility to antimicrobial resistance of natural antimicrobial peptides, we herein propose a host defense peptide-mimicking strategy for designing chimeric quinolone derivatives which may reduce the likelihood of antibacterial resistance.

Reactive bio-based flame retardant derived from chitosan, phytic acid, and epoxidized soybean oil for high-performance biodegradable foam.

Due to the shortage of global petrochemical resources, preparing biodegradable polyurethane foam (PUF) with excellent strength and resistance against fire is an important way for sustainable development. A reactive all bio-based flame retardant CPE was prepared using chitosan (CS), phytic acid (PA), and epoxidized soybean oil (ESO) as raw materials. Meanwhile, the bio-based PUF matrix, named ERP, was prepared with ESO, ricinoleic acid (RA) and 4,4-diphenylmethane diisocyanate (PMDI).

Gastric mucosal CD8T cells are recruited through CXCR5-CXCL13 axis in Helicobacter pylori infected subjects.

Gastric mucosal CD8 tissue-resident memory T (CD8T) cells are increased in Helicobacter pylori (H. pylori) infected subjects, but the characteristics and chemotactic mechanism of CD8T cells remain unknown. We demonstrated that C-X-C chemokine receptor 5 (CXCR5) was upregulated on gastric mucosal CD8T cells, and gastric CXCL13 was dominantly secreted by dendritic cells and macrophages in H.

Global, regional, and national burden of congenital heart disease, 1990-2021: a systematic analysis for the global burden of disease study 2021.

Unlabelled: Congenital heart disease (CHD) is a major birth defect characterized by structural and functional heart abnormalities. This study provides updated estimates of CHD prevalence, mortality, and disability using the Global Burden of Disease (GBD) 2021 database. We examined the age-standardized rates of CHD prevalence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021, stratified by gender, age group, and region.

A scalable strategy of "ball-milling-assisted laser scanning method" to achieve Cr2Ni3 catalyst: An unprecedented robust anode for oxygen evolution reaction.

Industrial water-alkali splitting is facing high energy consumption due to the high overpotential of commercial Ni mesh anode in oxygen evolution reaction (OER) processing. Herein, a simple ball-milling-assisted laser scanning strategy was employed to introduce the hardest Lewis acid chromium (Cr) into the Ni matrix to form Cr2Ni3 catalysts supported by Ni mesh, endowing such NiCr/Ni mesh anode a robust OER performance at a low-cost. It is shown that facilitating the self-adsorption of oxygen species and promoting the leaching of soluble Cr cations aids in reconstructing Ni cations into active (oxy)hydroxide species.

A Single HS-Releasing Nanozyme for Comprehensive Diabetic Wound Healing through Multistep Intervention.

Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive wound environments, such as hyperglycemia, bacterial infection, and impaired angiogenesis. However, current multistep interventions are complicated and need on-demand sequential release and synergy of multicomponents. Herein, a HS-releasing cascade nanozyme (FeS@Au), which is composed of ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), is developed as a single component to regulate glucose level, eliminate infection, and promote angiogenesis, achieving multistep interventions for comprehensive diabetic wound treatment.

Knockdown of ANXA3 regulates NF-κB/STAT3 pathway to alleviate inflammation and hyperproliferation in psoriasis models.

Psoriasis is an immune-mediated inflammatory skin disorder and its pathological mechanism remains incompletely understood. Detailed exploration of this mechanism is crucial to identify key regulatory molecules influencing its progression. In previous studies, Annexin A3 (ANXA3), a calcium-dependent phospholipid-binding protein from the annexin family, has been linked to psoriasis progression.

Metabolic regulation of amino acids provides an important basis for individualized nutritional therapy for patients with gastric cancer during the perioperative period.

Background: Gastric cancer is a prevalent malignancy worldwide, with early detection and treatment being vital to improving patient outcomes. Amino acids (AAs), as essential regulators in cancer cell metabolism, are implicated in the progression and response to treatment.

Methods: This study aimed to investigate the dynamics of plasma AA levels in gastric cancer patients preoperatively, postoperatively, and following nutritional intervention, comparing them to healthy controls.

Evaluation of respiratory muscle dysfunction in patients with idiopathic pulmonary fibrosis: a prospective observational study with magnetic resonance imaging.

Objective: Respiratory muscle dysfunction in patients with idiopathic pulmonary fibrosis (IPF) is a big challenge for treatment and rehabilitation. To quantitatively assess diaphragm and chest wall dysfunction using dynamic Magnetic Resonance Imaging (Dyn-MRI) in patients with IPF.

Methods: Ninety-six patients with IPF and 50 gender- and age-matched controls were prospectively included and underwent D-MRI with a dynamic fast spoiled gradient-recalled echo sequence.