Design, Synthesis, and Pharmacological Evaluation of Novel Tacrine Derivatives as Multi-target ANTI-Alzheimer's Agents In Rat Models.

Background: Alzheimer's disease is a progressive neurodegenerative disorder for which no curative drugs are available and treatment available is just palliative.

Objectives: Current research focused on design of Tacrine-Flavone hybrids as multitargeted cholinesterase and monoamine oxidase B inhibitors.

Methods: A total of 10 Tacrine- Flavone hybrids were designed, synthesized and characterized.

Ayurvedic management central serous retinopathy - A case report.

Background: Central Serous Retinopathy (CSR) is an eye disease that causes visual impairment ascribable to fluid accumulation in the retina's macular area. CSR leads to the blurring of vision associated with metamorphopsia. The cause of the disease is unknown.

Design Synthesis and Evaluation of Tacrine-flavone Hybrids as Multifunctional Cholinesterase Inhibitors for Alzheimer's Disease.

Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. The multifactorial etiology of AD has led to the design of multitarget directed ligands (MTDL) for AD. Tacrine an acetylcholinesterase (AChE) inhibitor was the first FDA approved drug for AD but is discontinued due to hepatotoxicity.

Multitarget Directed Ligand Approaches for Alzheimer's Disease: A Comprehensive Review.

Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disease, and a drug which targets a single protein would not provide a cure for this disease. Currently available drugs for AD are all palliative rather than curative. FDA approved only five drugs for the treatment of AD, which include tacrine, donepezil, galantamine, rivastigmine, and memantine.

Impact of land cover and land use change on runoff characteristics.

Change in Land Cover and Land Use (LCLU) influences the runoff characteristics of a drainage basin to a large extent, which in turn, affects the surface and groundwater availability of the area, and hence leads to further change in LCLU. This forms a vicious circle. Hence it becomes essential to assess the effect of change in LCLU on the runoff characteristics of a region in general and of small watershed levels (sub-basin levels) in particular.