Context: There is contradictory information regarding the prognostic importance of adipocytokines, hepatic and inflammatory biomarkers on the incidence of type 2 diabetes. The objective was to assess the prognostic relevance of adipocytokine and inflammatory markers (C-reactive protein - CRP; interleukin-1beta - IL-1β; interleukin-6- IL-6; tumour necrosis factor-α - TNF-α; leptin and adiponectin) and gamma-glutamyl transpeptidase (γGT) on the incidence of type 2 diabetes.
Methods: Prospective, population-based study including 3,842 non-diabetic participants (43.
Context: Several genetic risk scores to identify asymptomatic subjects at high risk of developing type 2 diabetes mellitus (T2DM) have been proposed, but it is unclear whether they add extra information to risk scores based on clinical and biological data.
Objective: The objective of the study was to assess the extra clinical value of genetic risk scores in predicting the occurrence of T2DM.
Design: This was a prospective study, with a mean follow-up time of 5 yr.
Objective: To compare in the Swiss population the results of several scores estimating the risk of developing type 2 diabetes.
Research Design And Methods: This was a single-center, cross-sectional study conducted between 2003 and 2006 in Lausanne, Switzerland. Overall, 3,251 women and 2,937 men, aged 35-75 years, were assessed, of which 5,760 (93%) were free from diabetes and included in the current study.