Publications by authors named "Remy G"

Lithium-ion battery electrodes are typically manufactured via slurry casting, which involves mixing active material particles, conductive carbon, and a polymeric binder in a solvent, followed by casting and drying the coating on current collectors (Al or Cu). These electrodes are functional but still limited in terms of pore network percolation, electronic connectivity, and mechanical stability, leading to poor electron/ion conductivities and mechanical integrity upon cycling, which result in battery degradation. To address this, we fabricate trichome-like carbon-iron fabrics via a combination of electrospinning and pyrolysis.

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Mitochondrial dysfunctions are implicated in several pathologies, such as metabolic, cardiovascular, respiratory, and neurological diseases, as well as in cancer and aging. These metabolic alterations are usually assessed in human or murine samples by mitochondrial respiratory chain enzymatic assays, by measuring the oxygen consumption of intact mitochondria isolated from tissues, or from cells obtained after physical or enzymatic disruption of the tissues. However, these methodologies do not maintain tissue multicellular organization and cell-cell interactions, known to influence mitochondrial metabolism.

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Evaluation of cartridge cases is essential within forensic ballistic analysis and is used in an attempt to establish a connection to the weapon used to fire it. This study consists of two experiments. The aims of Experiment 1 were to establish whether micro-CT is appropriate and repeatable for ballistic cartridge case analysis and if measurements can be extracted repeatably and reliably.

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Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the inter-relations between obesity and smoking are still not fully understood. We thus developed an experimental model of high-fat diet-fed obese C57BL/6 male mice chronically exposed to cigarette smoke.

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Purpose: To linguistically and cross-culturally translate the Anterior Knee Pain Scale into French and to evaluate the reliability and validity of this translated version of the questionnaire.

Methods: The translation part was performed in six stages, according to international guidelines: (i) two initial translations from English to French; (ii) synthesis of the two translations; (iii) backward translations into the original language; (iv) expert committee to compare the backward translations with the original questionnaire; (v) pre-final version testing and (VI) expert committee appraisal. To validate the French version of the Anterior Knee Pain Scale, we assessed its validity, reliability and floor/ceiling effects.

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Background & Aims: The role of tobacco smoke in the etiology of inflammatory bowel disease (IBD) is unclear. We investigated interactions between genes and smoking (gene-smoking interactions) that affect risk for Crohn's disease (CD) and ulcerative colitis (UC) in a case-only study of patients and in mouse models of IBD.

Methods: We used 55 Immunochip-wide datasets that included 19,735 IBD cases (10,856 CD cases and 8879 UC cases) of known smoking status.

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The controlling factors that underlie the growth of tumors have often been hard to identify because of the presence in this system of a large number of intracellular biochemical parameters. Here, we propose a simplifying framework to identify the key physical parameters that govern the early growth of tumors. We model growth by means of branching processes where cells of different types can divide and differentiate.

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Progression of chronic obstructive pulmonary disease (COPD) is linked to episodes of exacerbations caused by bacterial infections due to Streptococcus pneumoniae. Our objective was to identify during COPD, factors of susceptibility to bacterial infections among cytokine network and their role in COPD exacerbations. S.

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Chronic obstructive pulmonary disease (COPD) is a major clinical challenge mostly due to cigarette smoke (CS) exposure. Invariant natural killer T (iNKT) cells are potent immunoregulatory cells that have a crucial role in inflammation. In the current study, we investigate the role of iNKT cells in COPD pathogenesis.

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Introduction: A software of computerized physician order entry [CPOE] was developed by a data-processing company in collaboration with the Mont-Godinne University Hospital By 2006, parallel to the evolution of the software, the progressive implementation of CPOE was carried out, and currently covers 16 wards, the emergency room, the recovery rooms and the center of medical care [day hospital] as well as the day surgical center

Objectives: Complete computerization of the drug supply chain, including the regulation by the physician, the pharmaceutical validation, the delivery and the follow-up of stocks by pharmacy, the validation of the administration by the nurse and the tariffing of the drugs.

Method And Results: In 2006, a working group was created in order to validate specifications allowing the development of a software of CPOE, Linked to the computerized medical record. A data-processing company was selected in order to develop this software.

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Introduction: Ophtalmic infections and inflammations are often encountered during hospitalization. They require the preparation of "fortified" ophtalmic solutions, i.e.

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Nonhuman animals in captivity can experience environmental privation that results in their exhibiting abnormal behaviors. Environmental enrichment techniques can help improve their welfare. This study investigated the behavior of 8 zoo-housed oncilla cats (Leopardus tigrinus) in response to 2 odors (catnip and cinnamon) introduced individually into the animals' enclosures for 3 consecutive days.

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The p38 mitogen-activated protein kinase (p38MAPK) signal transduction pathway is an important regulator of cell processes, whose deregulation leads to the development and progression of cancer. Defining the role of each p38MAPK family member in these processes has been difficult. To date, most studies of the p38MAPK pathways focused on function of the p38α isoform, which is widely considered to negatively regulate malignant transformation; nonetheless, few reports address the p38γ and p38δ isoforms.

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[UNICEF against the tsunami].

Med Trop (Mars)

December 2010

The southeast Asian tsunami that caused massive death and destruction in December 2004 was met by an extraordinary outpouring of international generosity. Recovery work was initially slowed by a variety of problems including poor administrative organization, lack of coordination between partners, and legal impediments. However, it is now largely completed.

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The size of urban cat colonies is limited only by the availability of food and shelter; therefore, their population growth challenges all known population control programs. To test a new population control method, a free-roaming feral cat colony at the Zoological Park in the city of Rio de Janeiro was studied, beginning in 2001. The novel method consisted of performing a hysterectomy on all captured female cats over 6 months of age.

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All four members of the mammalian p38 mitogen-activated protein kinase (MAPK) family (p38alpha, p38beta, p38gamma and p38delta) are activated by dual phosphorylation in the TGY motif in the activation loop. This phosphorylation is mediated by three kinases, MKK3, MKK6 and MKK4, at least in vitro. The role of these MKK in the activation of p38alpha has been demonstrated in studies using fibroblasts that lack MKK3 and/or MKK6.

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Article Synopsis
  • Anti-TNFalpha treatment increases the risk of tuberculosis, often developing in severe forms like extrapulmonary or disseminated TB.
  • There is a phenomenon where patients experience paradoxical reactions—worsening of symptoms—after stopping TNFalpha inhibitors, suggesting immune restoration.
  • Guidelines from French and Spanish drug agencies have been established to prevent and manage tuberculosis cases in patients undergoing anti-TNFalpha treatment, leading to reduced incidence in Spain.
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Article Synopsis
  • - The study aimed to explore how levels of apolipoproteins C3 (APOC3) and E (APOE) in the blood relate to lipid and carbohydrate metabolism issues, as well as signs of lipodystrophy in HIV-1 patients on specific antiretroviral treatment.
  • - Conducted on a subset of 1,181 HIV-1-infected adults, it found that higher levels of APOC3 were linked to increased triglycerides and cholesterol, and these levels also rose with more severe glucose metabolism problems.
  • - The findings suggest that elevated APOC3 levels may indicate lipid and glucose metabolism disorders in these patients and are associated with clinical signs of insulin resistance and lipodystrophy. *
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Hantaviruses are cosmopolite anthropozoonosis considered as an emerging disease. Four pathogenic types for humans and part of the Bunyaviridae species are hosted by rodents and have been isolated: the Sin nombre virus responsible for the severe American respiratory form; the Hantaan and Seoul viruses responsible for hemorrhagic fevers with renal syndrome (HFRS) of severe to moderate expression in Asia and also in the Balkans; the Puumala virus responsible for HFRS of moderate expression or the socalled nephropathia epidemica in Europe. The Puumala virus is responsible for a minor form of the disease that is observed in areas of the Occidental sector of the ex-URSS, in Scandinavia and in the rest of Europe, notably in the North-East of France.

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Article Synopsis
  • A 55-year-old man was admitted to the hospital with a painless frontal tumor measuring 6 cm in diameter on his left forehead.
  • Imaging tests indicated that the tumor might be a subcutaneous metastasis, with further scans revealing issues in the lung, liver, and adrenal glands.
  • A biopsy ultimately confirmed that the tumor was a metastatic hepatocellular carcinoma, originating from the liver.
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Aims: To develop a population pharmacokinetic model for pyrimethamine (PYR) and sulfadoxine (SDX) in children with congenital toxoplasmosis.

Methods: Children were treated with PYR (1.25 mg kg(-1)) and SDX (25 mg kg(-1)) (Fansidar) plus folinic acid (Lederfoline) 5 mg).

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Article Synopsis
  • * Out of 54 samples, 52% tested positive via cell culture, while 76% were positive with the in-house RT-PCR and 80% with the new Penter RT-PCR test, highlighting its higher efficacy (P = 0.003).
  • * The Penter RT-PCR test is deemed reliable for diagnosing enterovirus-related meningitis and could enhance the treatment of associated neurological issues.
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  • A study compared the effectiveness and side effects of zidovudine (AZT) and stavudine (d4T) when used with lamivudine (3TC) and indinavir in HIV-1 patients who had prior treatment experience with other drugs.
  • The primary outcome was the time to virological failure, with no significant difference found between the AZT and d4T groups after 80 weeks of treatment.
  • Both treatment regimens showed similar rates of viral suppression and immune response improvement, indicating that switching from AZT to d4T did not provide additional benefits for heavily pretreated patients.
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