Publications by authors named "Remus Sebastian Sipos"

Bone is a complex tissue that fulfills the role of a resistance structure. This quality is most commonly assessed by bone densitometry, but bone strength may not only be related to bone mineral density but also to the preservation of bone cytoarchitectonics. The study included two groups of rats, ovariectomized and non-ovariectomized.

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The ongoing concern of the medical profession regarding chronic medication is related to increasing patient adherence and compliance to treatment and reducing medication side effects. In this respect, drugs represented by fixed-dose combinations of active substances within the same tablet have emerged. Such a principle can be extrapolated by following the potential beneficial effects that a chronic medication can have on chronic pathologies affecting different systems.

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Classical histological methods such as hematoxylin-eosin staining, have been, and in some areas still are, an important benchmark for the evaluation of biological tissues. However, the current method of assessment is primarily a qualitative assessment of the tissue under investigation. The aim of this paper is to contribute to the improvement of classical histological methods, by applying physical techniques that allow objective, quantitative data to be added to qualitative assessments, especially in areas where conflicting results are available.

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Article Synopsis
  • The study investigates how simvastatins and fenofibrates affect the femur bones of ovariectomized and non-ovariectomized Wistar albino rats using 1D 1H-NMR T2-distribution methods.
  • A total of 72 rats were divided into six groups and were analyzed at different time intervals after ovariectomy, with bone samples collected for analysis of moisture and pore distribution.
  • Results indicated that the effects of the drugs on bone structure varied significantly with treatment duration, emphasizing that treating healthy bones with these lipid-lowering medications is generally not advisable.
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