International expert guidance for defining and monitoring small bowel strictures in Crohn's disease on intestinal ultrasound: a consensus statement.

Background: Diagnostic imaging using CT enterography, magnetic resonance enterography, and intestinal ultrasound are important tools in evaluating stricturing Crohn's disease. Definitions of strictures have been developed for CT enterography and magnetic resonance enterography. However, expert recommendations for definitions and treatment response of strictures on intestinal ultrasound are not available.

Reliability of Intestinal Ultrasound for Evaluating Crohn's Disease Activity Using Point-of-care and Central Reading.

Background & Aims: Intestinal ultrasound (IUS) is increasingly used to assess Crohn's disease (CD) activity in clinical practice. However, application in clinical trials has been limited by heterogeneous scoring methods and concerns about reliability. We aimed to determine the inter- and intra-rater reliability of locally and centrally read IUS parameters for evaluating CD using prospectively performed scans.

Reliability of CT Enterography for Describing Fibrostenosing Crohn Disease.

Background Standardized methods to measure and describe Crohn disease strictures at CT enterography are needed to guide clinical decision making and for use in therapeutic studies. Purpose To assess the reliability of CT enterography features to describe Crohn disease strictures and their correlation with stricture severity. Materials and Methods A retrospective study was conducted in 43 adult patients with symptomatic terminal ileal Crohn disease strictures who underwent standard-of-care CT enterography at a tertiary care center at the Cleveland Clinic between January 2008 and August 2016.

Reliability and Responsiveness of Histologic Indices for the Assessment of Crohn's Disease Activity.

Background & Aims: The operating properties of histologic indices for evaluating Crohn's disease (CD) activity are poorly characterized. We assessed the reliability and responsiveness of existing histologic indices/items used in CD and ulcerative colitis (UC), in addition to 3 novel items, and developed exploratory ileal, colonic, and colonic-ileal CD instruments.

Methods: Blinded central readers independently reviewed paired baseline and week 12 image sets from the EXTEND trial.

Recommendations for Standardizing MRI-based Evaluation of Perianal Fistulizing Disease Activity in Pediatric Crohn's Disease Clinical Trials.

Background: Perianal fistulas and abscesses occur commonly as complications of pediatric Crohn's disease (CD). A validated imaging assessment tool for quantification of perianal disease severity and activity is needed to evaluate treatment response. We aimed to identify magnetic resonance imaging (MRI)-based measures of perianal fistulizing disease activity and study design features appropriate for pediatric patients.

Standardizing Scoring Conventions for Crohn's Disease Endoscopy: An International RAND/UCLA Appropriateness Study.

Background And Aims: Endoscopic assessment of disease activity is integral for evaluating treatment response in patients with Crohn's disease (CD). We aimed to define appropriate items for evaluating endoscopic activity and conventions for consistent endoscopic scoring rules in CD.

Methods: A 2-round modified RAND/University of California at Los Angeles Appropriateness Method study was conducted.

Conceptualizing teachers' interactions with resources in crossing languages and cultures.

This paper introduces this special issue aiming to deepen and extend research on mathematics teachers' work, from a resource perspective, by taking language and culture into account, and exploring two questions: How are teachers' interactions with resources interpreted and modeled across contexts? And, What challenges and insights emerge through recent efforts to engage these models in cross-cultural (and linguistic) research? The fields of resources, language and culture in mathematics education are each extensive, and we do not attempt to survey comprehensively across them. We have chosen instead to propose three approaches on resources in mathematics teachers' work that developed somewhat contemporaneously from three different countries with differing linguistic, curricular, and social contexts, corresponding to the work of the three guest editors. The models developed through these approaches are driven by the educational, and so cultural and material conditions of the time and the location of each author, and allow us to propose preliminary answers to our two guiding questions.

Reliability and responsiveness of endoscopic disease activity assessment in eosinophilic esophagitis.

Background And Aims: Endoscopic outcomes have become important measures of eosinophilic esophagitis (EoE) disease activity, including as an endpoint in randomized controlled trials (RCTs). We evaluated the operating properties of endoscopic measures for use in EoE RCTs.

Methods: Modified Research and Development/University of California Los Angeles appropriateness methods and a panel of 15 international EoE experts identified endoscopic items and definitions with face validity that were used in a 2-round voting process to define simplified (all items graded as absent or present) and expanded versions (additional grades for edema, furrows, and/or exudates) of the EoE Endoscopic Reference Score (EREFS).

An expert consensus to standardise clinical, endoscopic and histologic items and inclusion and outcome criteria for evaluation of pouchitis disease activity in clinical trials.

Background: Pouchitis is a condition with large unmet medical needs and no approved therapies. Lack of validated instruments to measure disease activity and treatment response is a major barrier to drug development.

Aim: To conduct a modified RAND/University of California Los Angeles appropriateness process to produce a standardised assessment of pouchitis disease activity in clinical trials.

Use of cloud radar Doppler spectra to evaluate stratocumulus drizzle size distributions in large-eddy simulations with size-resolved microphysics.

A case study of persistent stratocumulus over the Azores is simulated using two independent large-eddy simulation (LES) models with bin microphysics, and forward-simulated cloud radar Doppler moments and spectra are compared with observations. Neither model is able to reproduce the monotonic increase of downward mean Doppler velocity with increasing reflectivity that is observed under a variety of conditions, but for differing reasons. To a varying degree, both models also exhibit a tendency to produce too many of the largest droplets, leading to excessive skewness in Doppler velocity distributions, especially below cloud base.

Using Behavior Change Techniques to Guide Selections of Mobile Applications to Promote Fluid Consumption.

Objective: To determine the extent to which validated techniques for behavior change have been infused in commercially available fluid consumption applications (apps).

Materials And Methods: Coders evaluated behavior change techniques represented in online descriptions for 50 fluid consumption apps and the latest version of each app.

Results: Apps incorporated a limited range of behavior change techniques (<20% of taxonomy).

Effectiveness of ultrasound-guided corticosteroid injection for the treatment of gluteus medius tendinopathy.

Objective: The objective of our study was to evaluate the effectiveness of ultrasound-guided corticosteroid injection for the treatment of gluteus medius tendinopathy.

Subjects And Methods: We prospectively evaluated 54 consecutive patients (48 women, six men; mean age, 54.7 years; mean body mass index, 26 kg/m2) with a clinical diagnosis of gluteus medius tendinopathy.

Numeracy and communication with patients: they are counting on us.

Patient-centered interactive communication between physicians and patients is recommended to improve the quality of medical care. Numerical concepts are important components of such exchanges and include arithmetic and use of percentages, as well as higher level tasks like estimation, probability, problem-solving, and risk assessment--the basis of preventive medicine. Difficulty with numerical concepts may impede communication.

Demonstration of a high-temperature fiber-optic gas sensor made with a sol-gel process to incorporate a fluorescent indicator.

To make a gas sensor suitable for use at high temperatures, we have used a sol-gel-processing technique to bond a copper-exchanged zeolite fluorescence indicator onto the end of an all-silica optical fiber. Experimental results from single-fiber prototype sensors show they can be used to measure either the oxygen concentration or the equivalence ratio for gas mixtures containing weak or strong reductants, respectively.

Sub-Doppler resolution limited Lamb-dip spectroscopy of NO with a quantum cascade distributed feedback laser.

A quantum cascade distributed feedback laser operating at 5.2 microm is used to obtain sub-Doppler resolution limited saturation features in a Lamb-dip experiment on the R(13.5)1/2 and R(13.

Fluorescence characteristics of Cu-ZSM-5 zeolites in reactive gas mixtures: mechanisms for a fiber-optic-based gas sensor.

In situ measurements of the fluorescence spectra, intensity, and response time were made at elevated temperatures (~500 degrees C) for samples of Cu-ZSM-5 exposed to dilute mixtures of O(2) in N(2) and to various O(2)-reductant combinations in N(2). The results of these experiments are interpreted with a physical model of the oxidation/reduction kinetics of the copper ions. The fluorescence signal depends strongly on the gas composition, providing a mechanism for a gas composition sensor.

Evanescent-wave scattering by electrophoretic microparticles: a mechanism for optical switching.

The total internal reflection of light occurring at the interface between glass and a low-index liquid containing suspended microparticles can be electrically controlled. The particles are charged and the glass is coated with a thin, transparent conductor. When the conductor is biased to attract the particles, they scatter and absorb light from the evanescent optical field near the interface, thus reducing the reflectivity.

Loss mechanisms in optical light pipes.

A geometrical optics approach is used to develop a theoretical model for analyzing loss mechanisms in optical light pipes. Five mechanisms are identified: intrinsic absorption, bulk scattering, losses that are due to roughness at the core-cladding interface, losses that are due to large-scale defects at the core-cladding interface, and losses that are due to absorption in the cladding material; and the effects of each of these on light-pipe transmission are considered. An approximate model appropriate for slightly rough surfaces is used to estimate the loss that is due to interface roughness.

High-resolution nonlinear laser spectroscopy of room-temperature GaAs quantum-well structures: observation of interference effects.

We describe frequency-domain four-wave mixing spectroscopy measurements near the fundamental band edge in room-temperature GaAs multiple quantum wells. The line-shape information gives a measure of the dynamical behavior of the material and what is to our knowledge the first observation of an interference line shape due to a dominant slow contribution to the nonlinear response.