Notch Signaling Is Associated with Pulmonary Fibrosis in Patients with Pigeon Breeder's Lung by Regulating Oxidative Stress.

This study explored the molecular mechanism underlying the association of Notch signaling and oxidative stress with the occurrence of pulmonary fibrosis in patients with pigeon breeder's lung (PBL). Rat models of fibrotic PBL were constructed with freeze-dried protein powder, and the animals were divided into the control (intratracheal instillation of normal saline;  = 9), M (PBL model; intratracheal instillation of freeze-dried protein powder;  = 9), and M + D (PBL+ the Notch inhibitor DAPT;  = 9) groups. Immunohistochemistry was employed to observe the protein levels of pathway factors and -SMA, and the levels of ROS, GSH-PX, SOD, and MDA were observed using ELISA.