Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4,6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl]pyrrolo[3,4-]pyrrole-1,3(2,5)-diones as Anti-Inflammatory Agents with Dual Inhibition of COX and LOX.

In the present study, we characterize the biological activity of a newly designed and synthesized series of 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl] derivatives of pyrrolo[3,4-]pyrrole -. The compounds were obtained with good yields of pyrrolo[3,4-]pyrrole scaffold - with secondary amines in CHOH. The chemical structures of the compounds were characterized by H-NMR, C-NMR, FT-IR, and MS.