Publications by authors named "Remi Eyraud"
Article Synopsis
- Primary open-angle glaucoma (POAG) is a common cause of blindness, linked to increased intraocular pressure and damage to the optic nerve and retinal cells, making early detection crucial for preserving vision.
- Traditional diagnosis is challenging due to the disease's asymptomatic nature in its early stages, but recent research indicates that analyzing tear fluid (TF) for protein changes can provide valuable biomarkers.
- A new method using differential scanning fluorimetry (nanoDSF) identified distinct TF protein profiles in 311 patients, allowing for a 70% identification rate of POAG, while machine learning minimized false positives to 13.5%, revealing significant changes in specific proteins and ligands associated with glaucoma.
Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults. Recently, we demonstrated that plasma denaturation profiles of glioblastoma patients obtained using Differential Scanning Fluorimetry can be automatically distinguished from healthy controls with the help of Artificial Intelligence (AI). Here, we used a set of machine-learning algorithms to automatically classify plasma denaturation profiles of glioblastoma patients according to their EGFR status.
View Article and Find Full Text PDFGlioblastoma is the most frequent and aggressive primary brain tumor. Its diagnosis is based on resection or biopsy that could be especially difficult and dangerous in the case of deep location or patient comorbidities. Monitoring disease evolution and progression also requires repeated biopsies that are often not feasible.
View Article and Find Full Text PDFPurpose: The Grade Group (GG) classification is recommended by guidelines as a reliable prognostic factor of prostate cancer. However, most studies have been performed on the Caucasian population. Our objective was to validate GG classification as a safe way to classify intermediate- and high-risk patients with African ancestry.
View Article and Find Full Text PDFPurpose: Active surveillance is a treatment option for favorable risk prostate cancer. However, data are missing on populations of African descent. We evaluated the safety and benefit of active surveillance in an African Caribbean cohort with favorable risk prostate cancer.
View Article and Find Full Text PDFPurpose: To evaluate the feasibility of perineal robot-assisted laparoscopic radical prostatectomy (P-RALP) in the cadaver model.
Methods: The prostate was assessed by ultrasonography and cystoscopy in the lithotomy position. After incision and subcutaneous dissection, a single-port device was placed and the robot was docked.
Objective: To compare the outcomes of active surveillance (AS) series between African American men (AAM) and non-AAM diagnosed with low-risk prostate cancer at 3 medical centers.
Methods: Between 2005 and 2012, 214 men accepted AS on the basis of favorable clinical features and parameters after initial and repeat biopsy. Failure was defined as increase in Gleason score >6, total positive cores >33%, maximum cancer volume in any core >50%, or a prostate-specific antigen >10 ng/mL.
Objective: To analyse the outcomes of robot-assisted partial nephrectomy (RAPN) for completely endophytic renal tumours.
Patients And Methods: Medical records of patients who had undergone RAPN for a completely endophytic (i.e.
Background: With the wider adoption of minimally invasive partial nephrectomy (PN), intermediate- and long-term outcomes data are needed to make firm conclusions about oncologic and functional efficacy, especially for robot-assisted PN (RPN).
Objective: To report intermediate-term oncologic and renal functional outcomes of RPN.
Design, Setting, And Participants: We performed a chart review of patients who had undergone RPN since June 2006; patients with a minimum of 2 yr of follow-up were included in this study.
Objective: To compare perioperative outcomes of robot-assisted partial nephrectomy (RAPN) for hilar vs nonhilar tumors.
Materials And Methods: The study retrospectively reviewed 364 patients with available computed tomography scans undergoing RAPN. Demographic data and perioperative outcomes results were compared between the hilar (group 1, n = 70) and nonhilar tumors (group 2, n = 294).
Objective: To demonstrate the feasibility, and to report our single-centre perioperative outcomes of repeat robot-assisted partial nephrectomy (RAPN).
Patients And Methods: From June 2006 to June 2012, 490 patients underwent RAPN for a renal mass at our centre. Of these patients, nine who had undergone previous ipsilateral nephron-sparing surgery (NSS) were included in the analysis.
Objective: To evaluate the feasibility of pure robotic natural orifice translumenal endoscopic surgery (R-NOTES) nephrectomy.
Methods: Two R-NOTES nephrectomy approaches were attempted in 3 female cadavers. A single-port device was inserted through an incision in the posterior vaginal fornix.
Objective: To assess the feasibility of robotic transrectal hybrid natural orifice translumenal endoscopic surgery (NOTES) nephrectomy and adrenalectomy.
Materials And Methods: A male cadaver was used for the present investigation and placed in lithotomy position. An 8- and 12-mm port was inserted through the same periumbilical skin incision.
Purpose: We report a comparative analysis of a large series of laparoscopic and robotic partial nephrectomies performed by a high volume single surgeon at a tertiary care institution.
Materials And Methods: We retrospectively reviewed the medical charts of 500 patients treated with minimally invasive partial nephrectomy by a single surgeon between March 2002 and February 2012. Demographic and perioperative data were collected and statistically analyzed.
Objective: To assess the impact of imperative or elective indications on the perioperative outcomes of patients undergoing robotic partial nephrectomy.
Materials And Methods: Between January 2008 and August 2011, 381 consecutive robotic partial nephrectomies were retrospectively included. Two groups of patients were identified: those who underwent the procedure for an imperative indication (n = 98) and those who underwent the procedure for an elective indication (n = 283).
Purpose: We evaluated the change in renal function after renal cryoablation and partial nephrectomy based on tumor complexity according to the R.E.N.
View Article and Find Full Text PDFBackground And Purpose: Ureteroneocystostomy can be used for the treatment of patients with a wide variety of ureteral pathology. Over the last decade, robot-assisted surgery has become more commonly used as a minimally invasive approach for reconstructive upper urinary tract procedures. The aim of this study is to present our experience with robot-assisted ureteroneocystosctomy (RUNC) with a comparison with that of open ureteroneocystostomy (OUNC).
View Article and Find Full Text PDFContext: Centres worldwide have been performing partial nephrectomies laparoscopically for greater than a decade. With the increasing use of robotics, many centres have reported their early experiences using it for nephron-sparing surgery.
Objective: To review published literature comparing robotic partial nephrectomy (RPN) with laparoscopic partial nephrectomy (LPN).
Background: Recent studies showed that robotic partial nephrectomy (RPN) offered outcomes at least comparable to those of laparoscopic partial nephrectomy (LPN). LPN can be particularly challenging for more complex tumors.
Objective: To compare the perioperative outcomes of patients undergoing LPN or RPN for a single renal mass of moderate or high complexity.