Publications by authors named "Remco R Makkinje"
Purpose: Overall survival in patients with osteosarcoma is only 60%. Poor response to chemotherapy is the dominant risk factor for poor survival. Pharmacogenetic research can offer possibilities to optimize treatment and improve outcome.
View Article and Find Full Text PDFThe highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts.
View Article and Find Full Text PDFBackground: Treatment strategies blocking tumour necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA). However, a significant subset of patients does not respond for unknown reasons. Currently, there are no means of identifying these patients before treatment.
View Article and Find Full Text PDFArticle Synopsis
- - We conducted a large genome-wide association study on bladder cancer involving 3,532 cases and 5,120 controls, then replicated with an additional 8,382 cases and 48,275 controls across multiple studies.
- - We discovered three new regions linked to bladder cancer on specific chromosomes, which could help identify risk factors and mechanisms behind the disease.
- - The study also confirmed four previously known associations and revealed interactions between certain genetic factors and smoking, enhancing our understanding of bladder cancer risk.