Development and validation of a pentaplex PCR assay for rapid detection of bla bla, bla bla and the PBP3 insert in Enterobacterales.

Background: There is a high diversity of beta-lactamases in gram negative pathogens, making them difficult to treat. In the presence of OXA-1 and ampC, PTZ is no longer clinically relevant when treating Enterobacterales expressing ESBLs. Further, MBL infections are often treated with the combination of ceftazidime/avibactam with aztreonam.

Implementation of positive psychology to surmount demoralization caused by a cataclysm in select works of Svetlana Alexievich.

Background: Cataclysm refers to a large-scale and violent event involving disaster, catastrophe, calamity, and tragedy. The recent surge of a pandemic (coronavirus disease 2019 (COVID-19)), humanitarian crisis in Sudan, civil unrest, and war, such as the attacks in Syria and Ukraine, reiterate the need to address the trauma attached to such catastrophes. This study focuses on adapting positive psychology, one of the newest branches of psychology to emerge, to help human beings prosper and lead healthy, happy lives.

Activity of Two Cefepime-Based Novel Combinations, Cefepime/Taniborbactam and Cefepime/Zidebactam, against Carbapenemase-Expressing Collected in India.

In recent times, discovery efforts for novel antibiotics have mostly targeted carbapenemase-producing Gram-negative organisms. Two different combination approaches are pertinent: β-lactam-β-lactamase inhibitor (BL/BLI) or β-lactam-β-lactam enhancer (BL/BLE). Cefepime combined with a BLI, taniborbactam, or with a BLE, zidebactam, has been shown to be promising.

A comprehensive study and extensive review of morphological variations of liver with new insights.

Purpose: Liver is divided into four anatomical lobes presenting minor fissures and invisible major fissures. The prevalence of Accessory Fissures in liver ranges widely from 6 to 94%. The morphometric analysis of individual lobes is also scarce in literature.

Perceptions of Medical Undergraduate Students on Curricular Changes in Anatomy: An Embedded Design Mixed Method Study.

Introduction: Implementation of competency-based medical education (CBME) offers challenges to the faculty and students. As a part of the new curriculum by the National Medical Council of India, we introduced certain teaching and assessment modifications in anatomy. There are few studies on the actual implementation of CBME.

SKINTED: A Rare Complication After Total Knee Arthroplasty.

Background: Surgery of the knee, injury to the infrapatellar branch of the saphenous nerve, traumatic eczematous dermatitis is a neuropathic dermatitis specific to total knee arthroplasty (TKA), occurring around the healed surgical scar area. Very few case reports exist in orthopaedic literature regarding this rare skin complication after TKA. We report a series of cases and estimated the incidence of this condition in our institute.

The identity of Rasbora neilgherriensis (Teleostei: Danionidae), with a re-description.

Rasbora neilgherriensis Day, long considered a synonym of Rasbora daniconius or Rasbora dandia, is re-described and shown to be a valid species based on an examination of type and recently-acquired topotypical specimens from the Western Ghats of India. The species is characterised by a complete lateral line with 32-34 pored scales on body, ½5-6/1/2½ scales in transverse line on body, a mid-lateral stripe that is 2½ scales wide anterior to the pelvic fin and 1-1½ scales wide on the caudal peduncle, and a caudal fin that is emarginate to forked with broadly rounded lobes. The species was recorded from the Cauvery River Basin in Kerala and Tamil Nadu, India, at elevations ranging from 710 m to 2015 m above sea level, in stream stretches with relatively denser riparian canopy cover.

Infusing the axioms of clinical reasoning while designing clinical anatomy case vignettes teaching for novice medical students: a randomised cross over study.

The clinical reasoning skills is often gained when the biomedical knowledge is broadened and deepened alongside exposure to patients. The 'ideal' blend of axioms of clinical reasoning and case based learning would establish the pedagogical bridges right from the first year of medical education. So this study aimed to investigate the perceived importance and efficacy of teaching clinical reasoning skills among first year medical students, as this has not previously been described.

Evaluating the effectiveness of integrating radiological and cross-sectional anatomy in first-year medical students - A randomized, crossover study.

Context: Radiological anatomy (RA) knowledge is essential for the current-day clinical practice due to the rapid development in imaging technologies. As there is a long interval between learning RA in the 1 year and applying it in their clinical disciplines impedes their functional understanding, this study has been planned to provide the students with a right mix of anatomy and radiology in order to promulgate deeper medical comprehension.

Aim: This study aimed to evaluate the effectiveness of integrated RA in honing the radiological reasoning abilities in 1 year medical students and to develop critical thinking skills through small-group, case-based learning experience.

Are Footedness and Lateral Postures Better Predictors of Hemispheric Dominance Than Handedness: A Cross-sectional Questionnaire-Based Clinical and Pedigree Study.

 Approximately 9 out of 10 individuals show right-hand dominance. The remaining 10% include left-hand dominant and mixed handed/ambidextrous individuals. Laterality, lateral postures or lateral preference is defined by various authors as the most comfortable posture that an individual prefers to assume.

Pregnancy among unmarried adolescents and young adults.

Objectives: To determine the risk factors for pregnancy among unmarried adolescents and young adults.

Methods: Case-control study was done over a period of 2 years. Data collected from 181 unmarried abortion seekers and 181 unmarried non-pregnant controls (≤24 years) attending three Medical Colleges of Kerala.

Cytokinesis blocked micronucleus assay of peripheral lymphocytes revealing the genotoxic effect of formaldehyde exposure.

Formaldehyde (FA), which is said to be a carcinogenic agent, is commonly used in anatomy laboratories. This study used the cytokinesis blocked micronucleus assay (CBMN) to assess DNA damage due to FA exposure by measuring the frequency of micronuclei (MN) in lymphocytes. The extent of DNA damage was assessed with respect to the duration of exposure.

Androgen insensitivity syndrome: ten years of our experience.

Abnormalities of secondary sexual differentiation manifest in varying degrees depending upon the severity of the underlying cause. Primary amenorrhea in phenotypic females is caused by several different factors, including hormonal imbalance, nutritional deficiency and sex differentiation abnormalities. Androgen insensitivity syndrome (AIS) accounts for a large proportion of such cases in phenotypic females but genetically male individuals.

Mucosal disorders with oral epithelial dysplasia risk--development of a simple screening tool for general health care setting.

Objectives: Oral visual screening can avert oral cancer mortality. Oral premalignancies are currently considered as separate, individual disorders. The objective was to develop a simple clinical screening tool to detect oral premalignancies in general health care setting and validate diagnostic accuracy against Oral Medicine specialist examination as gold standard.

Bilateral Variability of the Quadriceps Angle (Q angle) in an Adult Indian Population.

Objectives: The objective of this study was to document and explain bilateral differences in the Q angle.

Materials And Methods: Two hundred limbs of healthy adult Indian volunteers were studied. The Q angle was measured using a goniometric method with the subjects supine, quadriceps relaxed and lower limbs in neutral rotation.

Domino alkylation/oxa-Michael of 1,3-cyclohexanediones: steering the C/O-chemoselectivity to reach tetrahydrobenzofuranones.

An unprecedented domino synthesis of tetrahydrobenzofuran-4-ones is described implicating chemoselective alkylation of various 1,3-cyclohexanediones with bromocrotonate or crotonitrile followed by oxa-Michael cyclization. Further transformations of this core to reach molecular diversity are also presented.

Utilization of rehabilitation services by rural households with disabled preschool children.

We conducted this study to find the extent of utilization of services and, identification of factors which determine the use of such services in rural families with disabled preschool children. Participants included disabled children in a Unicef supported cross sectional survey conducted in a rural ICDS block. The overall proportion of non-utilization of services was found to be 52.

Incidence of morphological variants of mandibular lingula.

The ligual of mandible is a tongue shaped bony projection on the medical surface of the ramus close to the posterior margin of the mandibular foramen. Since the inferior alveolar nerve enters the mandibular foramen to supply the strctures of the lower jaw, the relationship of lingula to the inferior alveolar nerve is of clinical significance to dental surgeons. It becomes a necessety to know the morphology of linguls so as to preserve the important structures during surgical interference of mandible around the lingula region.