Publications by authors named "Rekhadevi Perumalla Venkata"
Article Synopsis
- Repeated heating of cooking oils, particularly sunflower oil, generates harmful substances called polycyclic aromatic hydrocarbons (PAHs) that can cause cancer.
- A study conducted on Wistar rats showed that consuming food cooked in oils heated multiple times resulted in significant DNA damage and increased genetic abnormalities in their blood and bone marrow.
- The findings suggest that dietary habits involving the use of repeatedly heated oils can lead to serious long-term health risks due to the genotoxic effects of PAHs and the free radicals they create.
Increased utilization and exposure levels of Magnesium oxide (MgO) nanoparticles (NPs) to humans and environment may raise unexpected consequences. The goal of this study was to evaluate the toxicological implications of MgO NPs and MPs after 28 day repeated oral administration in Wistar rats with three different doses (250, 500, and 1000 mg/kg). The MgO particles were characterised systematically in order to get more insights of the toxicological behaviour.
View Article and Find Full Text PDFConsumption of repeatedly heated cooking oil has been a regular practice without knowing the harmful effects of use. The present study is based on the hypothesis that, heating of edible oils to their boiling points results in the formation of free radicals that cause oxidative stress and induce damage at the cellular and molecular levels. Peroxide value of heated oil, histopathological alterations, antioxidant enzyme levels and blood biochemistry were determined in Wistar rats treated with the .
View Article and Find Full Text PDFObjective: This study was designed to determine the genotoxic effect of exposure to a mixture of pesticides in 106 female agricultural workers employed in cotton fields from India.
Methods: Comet, micronucleus and chromosomal aberrations tests were carried out in peripheral blood lymphocytes. Micronucleus test was also performed in buccal epithelial cells.
Objective: We aimed to study the genotoxic effects in traffic police who are occupationally exposed due to higher free radical generation.
Methods: Ambient and breathing zone air samples were analyzed blood samples were collected for analysis of antioxidant enzymes Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and free radicals - nitric oxide (NO) and malondialdehyde (MDA) levels using a spectrophotometer. DNA damage was measured with the comet assay.
Objectives: Biomonitoring of exposure in workplaces has gained importance in evaluation of human health hazards. Since occupational exposure to petroleum hydrocarbons may have deleterious effects, genotoxicity risk among 200 fuel filling station attendants (FFSAs) and 200 matched controls was investigated.
Methods: The probable genetic damage was determined by comet assay and micronucleus test in peripheral blood lymphocytes (PBL) of study subjects.