Fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants.

Background: Fungal infections are common cause of morbidity and mortality in very low birth weight Infants

Objectives: To evaluate the efficacy of prophylactic Fluconazole in preventing fungal colonization and invasive fungal infection in VLBW infants.

Design: Prospective, randomized, double blind placebo controlled clinical trial.

Setting: Tertiary level Neonatal intensive care unit.

Room air vs. 100 per cent oxygen for neonatal resuscitation: a controlled clinical trial.

The aim of the study was to determine whether neonates resuscitated with room air compared with 100 per cent oxygen in the delivery room were less likely to have hypoxic ischemic encephalopathy and/or death before discharge. A controlled clinical trial was carried out at a tertiary care institute. All newborns weighing 1000 g or more with apnea or gasping respiration and/or heart rate less than 100 beats/min requiring positive pressure ventilation after initial steps of resuscitation were included.

Sirenomelia apus with vestigial tail.

Sirenomelia is an exceptionally rare congenital malformation characterized by complete or near complete fusion of lower limbs. A newborn with clinical features of sirenomelia including fused lower limbs in medial position, absent fibula, anal atresia, complete absence of urogenital system (bilateral renal agenesis, absent ureters, urinary bladder, absent internal and external genitalia), a single umbilical artery and a vestigial tail is reported. Association of vestigial tail with sirenomelia is not described in the literature.

Fanconi's anemia in newborn.

Fanconi's anemia (FA) is a paradigm for congenital anomalies, aplastic anemia and predisposition to malignancies. Identification of the disease at birth is based on characteristic physical malformations, as hematologic manifestations at birth are extremely rare. We report a case of FA in a newborn who presented with anophthalmia, unilateral radial ray defect, hemivertebrae and thrombocytopenia.

Analgesic effect of oral glucose in preterm infants during venipuncture--a double-blind, randomized, controlled trial.

The aim of the present study was to evaluate the effect of different concentrations of glucose on measures of neonatal pain during venipuncture. A randomized, double-blind, placebo controlled trial was carried out at the neonatal intensive care unit at the King Edward Memorial Hospital. Sixty healthy preterm infants of gestation age 28-37 weeks and postnatal age 2-28 days were randomized to receive 2 ml of one of three solutions (sterile water, 10 per cent wt/vol.