Publications by authors named "Reka Molnar"
Article Synopsis
- * Research showed that smokers, both with and without CP, have higher sweat chloride levels and lower CFTR expression, indicating impaired CFTR activity due to smoking.
- * Exposure to cigarette smoke and associated heavy metals like cadmium harms pancreatic function by reducing fluid and bicarbonate secretion and increasing intracellular calcium and ATP depletion.
Article Synopsis
- This study explores how hypertriglyceridemia, linked to atherosclerosis, affects the function and structure of the blood-brain barrier (BBB) using a specific mouse model (APOB-100 transgenic).
- Researchers examined the role of interleukin (IL)-6, a pro-inflammatory cytokine, in impairing BBB characteristics and whether IL-10, an anti-inflammatory cytokine, could counteract these effects.
- Results showed that IL-6 increased permeability and decreased the activity of critical BBB proteins in the mice, while IL-10 helped mitigate these changes, indicating a potential therapeutic target for BBB dysfunction.
The quantitative detection of radiation caused DNA double-strand breaks (DSB) by immunostained γ-H2AX foci using direct stochastic optical reconstruction microscopy (dSTORM) provides a deeper insight into the DNA repair process at nanoscale in a time-dependent manner. Glioblastoma (U251) cells were irradiated with 250 keV X-ray at 0, 2, 5, 8 Gy dose levels. Cell cycle phase distribution and apoptosis of U251 cells upon irradiation was assayed by flow cytometry.
View Article and Find Full Text PDFKey Points: Acute biliary pancreatitis is a significant clinical challenge as currently no specific pharmaceutical treatment exists. Intracellular Ca overload, increased reactive oxygen species (ROS) production, mitochondrial damage and intra-acinar digestive enzyme activation caused by bile acids are hallmarks of acute biliary pancreatitis. Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel that has recently emerged as an important contributor to oxidative-stress-induced cellular Ca overload across different diseases.
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- The study investigates the secretory processes of pancreatic epithelial cells, noting that primary cells are hard to study and pancreatic organoid cultures might offer a better model for research.
- Researchers compared gene expression, morphology, and functionality between primary isolated pancreatic ductal cells and organoids, finding significant similarities in ion channel and transporter expression between the two.
- The results indicate that pancreatic organoids mimic primary ductal cell activities, making them a promising model for studying pancreatic ion transport and developing treatments for conditions like cystic fibrosis and chronic pancreatitis.
Article Synopsis
- A new compound, ASA-Tris, was developed from acetylsalicylic acid and Tris to have similar anti-inflammatory effects to ASA but with less damage to the digestive system.
- In a study on rats with colitis, ASA-Tris and mesalamine treatments reduced inflammation and tissue damage significantly more than ASA alone, which still caused some gastric injury.
- The findings suggest that ASA-Tris is more effective in protecting against colonic injury in inflammatory conditions compared to traditional ASA, making it a promising alternative for treatment.
Variation in nectar volume and sugar concentration of Allium ursinum L. ssp. ucrainicum in three habitats.
ScientificWorldJournal
September 2012
Floral nectar volume and concentration of ramson (Allium ursinum L. ssp. ucrainicum) were investigated in three different habitats, including two types of sessile oak-hornbeam association on brown forest soil with clay illuviation and a silver lime-flowering ash rock forest association on rendzina.
View Article and Find Full Text PDFThe present investigation describes the preparation and characterization of novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (gamma-PGA) with bivalent lead ion. The prepared nano-systems were stable in aqueous media at low pH, neutral and mild alkaline conditions. The particle size and the size of the complexes were identified by dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements.
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