Prognostic Significance of C-MYC and EGFR Overexpression in Gastrointestinal Stromal Tumors: An Immunohistochemical Study.

Introduction: In addition to mutations in KIT and PDGFRA, many other genetic alterations have been described in gastrointestinal stromal tumors (GISTs), including amplifications of C-MYC and EGFR, which are often associated with increased protein expression. The main of this study was to investigate the prognostic significance of C-MYC and EGFR expression in GISTs using immunohistochemistry (IHC).

Methods: We collected all GIST cases over a 16-year period.

Prognostic significance of tumor suppressor protein p53 in prostate cancer.

Introduction: The p53 gene mutation is one of the most common genetic alterations in many cancers. In prostate cancer (PCa), it has been associated with a poor prognosis, tumor progression and aggressiveness. P53 mutation induces an abnormal protein expression in related tissues.

Prognostic significance of E-Cadherin and B-Catenin in non-muscle invasive bladder cancer.

Non muscle invasive bladder cancer (NMIBC) has unpredictable outcomes with a variable risk of recurrence and progression. Many clinic-pathological prognostic factors have been identified but remain insufficient, raising the need to investigate new biomarkers. The aim of our study was to assess the prognostic value of the immunohistochemical (IHC) markers E-Cadherin and B-Catenin in NMIBC.

Immunochemistry-based quantification of tumor-infiltrating lymphocytes and immunoscore as prognostic biomarkers in bladder cancer.

Background: Tumor-infiltrating lymphocytes (TILs) and the derived immunoscore (IS) have gained considerable attention over the last decade as prognostic markers in many solid cancers. However, in bladder cancer (BC), their prognostic value is not clearly established.

Methods: The present study aimed to quantify the TILs rates in BC, assess the derived immunoscore, and investigate their prognostic value.

Impact of respiratory muscle training on clinical and functional parameters in COVID-19 recovered patients.

Introduction: early respiratory rehabilitation is required for patients with coronavirus virus disease 2019 (COVID-19) sequelae to reduce the risk of serious disabilities after hospital discharge.

Methods: it was a comparative prospective study including patients with persistent symptoms one month after discharge. The patients were hospitalized at the pneumology department D of Abderahman Mami hospital for COVID-19 pneumonia.

Immunohistochemical analysis of myeloperoxidase expression in cutaneous leucocytoclastic vasculitis.

Myeloperoxidase (MPO) is a pro-oxidant enzyme mainly found in the azurophilic granules of neutrophils. It not only displays a key role in the intracellular microbial killing process but also contributes to the extracellular clearance of several pathogens. This study aimed to detect MPO in cutaneous leukocytoclastic vasculitis (LCV) using immunohistochemistry.

Correction to "Adsorption of Methyl Orange from an Aqueous Solution onto a BPPO-Based Anion Exchange Membrane".

[This corrects the article DOI: 10.1021/acsomega.2c03148.

Reclassification of papillary thyroid microcarcinoma (pMCT) according to the "Porto proposal" criteria.

Introduction: pMCT is defined as a variant of papillary carcinoma that measures≤1 cm in diameter and which is characterized by an excellent prognosis. Recently, a proposal has been advanced to use the designation of papillary mirotumour (pMT) for pMCTs with no risk factors .

Aim: In this study, we aimed to reclassify pMCTs according to the Porto proposal(Pp) criteria.

Bone metastatic carcinoma coexisting with plasma cell myeloma: a case report.

Objective: Multiple myeloma is a clonal plasma cell proliferation often causing bone lytic lesions. It is sometimes challenging to differentiate these lytic lesions associated with multiple myeloma from bone destruction due to a metastasis. Although coexistence of solid tumors and plasma cell myeloma in one patient has been described, synchronous skeletal metastases from both neoplasms occurring in the same bone lesion is exceptional.

Adsorption of Methyl Orange from an Aqueous Solution onto a BPPO-Based Anion Exchange Membrane.

In this research, the development of a novel brominated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO)-based homogeneous anion exchange membrane (AEM) via the solution casting method was reported. Fourier transform infrared spectroscopy was used to confirm the successful development of the BPPO-based AEM. The prepared AEM showed excellent thermal stability.

Prognostic value of CD44s expression in urothelial bladder tumors.

Unlabelled: Urothelial bladder carcinoma (UBC) includes a large group of malignancies with a variable clinical behavior. Despite remarkable developments in recognition of bladder carcinogenesis and prognostic factors, the recurrence rate is still high. Thus, identification of novel biomarkers involved in tumor cell invasion and metastatic dissemination is a constant challenge.

Cyclin D1: potential utility as marker for Langerhans cell histiocytosis.

Langerhans cell histiocytosis (LCH) is a rare disorder of unknown etiopathogenesis. Diagnosis is based on the identification of CD1a positive histiocytic infiltrate. Activation of the mitogen-activated-protein-kinase (MAPK) is constantly observed in LCH and therefore downstream markers such as cyclin D1 may be a useful marker for LCH.

Comparative expression profile of CD10 and cyclin D1 in cutaneous histiocytofibroma and dermatofibrosarcoma.

Dermatofibrosarcoma protuberans (DFSP) and histiocytofibroma (HF) are two rare fibrohistiocytic tumors, with some overlapping pathologic features. Immunohistochemistry is very useful in these cases. CD34 is a commonly used marker.

SARS-CoV-2 vaccine induced Sweet syndrome : a case report.

Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis is a rare cutaneous disorder characterized by specific clinical, biological and microscopic findings. Although the exact cause of SS is still unknown, it may be triggered by infections, malignancies and drugs but also occurring after vaccinations such as bacille calmette guerin vaccination and influenza vaccine. While the recently discovered SARS COV2 vaccines are almost safe, many cutaneous and extracutaneous minor adverse effects are reported.

EpCAM (MOC-31) - immunohistochemical expression in papillary thyroid carcinoma and non invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).

Introduction: Ep-CAM, is a cell adhesion glycoprotein located on the basolateral cell membrane surface and in the cytoplasm of most normal epithelial cells. It has also been described to be expressed in several malignancies such as lung, digestive, prostate and renal carcinomas suggesting it has a potential role in carcinogenesis.  In thyroid carcinoma, Ep-CAM expression has rarely been studied especially in papillary thyroid carcinoma.

A remarkable concept of learning in times of educational confinement Social media and pathologist.

Social media are inevitably becoming part of our lives. The increasing popularity of these platforms revolutionized communication among healthcare workers and has irrevocably changed the terms of classic learning models. Pathologists all over the world are very active on social media making it a new pedagogical paradigm in pathology education.

[Orthodontic intrusion using mini-screws].

Introduction: Dental intrusion has long been considered one of the most difficult movements to induce in orthodontics. Using conventional mechanics, the main difficulty lies in the need to ensure anchorage control, which is highly complicated to achieve, so as to avoid parasitic movements. In this framework, mini-screws have proven to offer a very effective means of anchorage, allowing greater control over intrusion of the anterior and posterior teeth and a simpler biomechanical movement opening up new therapeutic perspectives for the orthodontist.

Mixed tumor of the kidney.

Mixed epithelial and stromal tumour (MEST) of the kidney, is a recently recognized and rare entity .We herein reported the case of a 56 years old post-menopausal woman who presented with right abdominal pain. Her physical examination was unremarkable.

Autoimmune gastritis: assessment of OLGA and OLGIM staging systems.

Background: Autoimmune gastritis present a risk of cancer related to atrophy and intestinal metaplasia. Two recent classifications OLGA (Operative Link on Gastritis Assessment) and OLGIM (Operative Link on Gastritic Intestinal Metaplasia assessment) have been proposed to reveal the high progressive risk forms (stages III and IV).

Aim: To evaluate the OLGA and OLGIM staging systems in chronic autoimmune gastritis.

Analysis of Expression during the Infectious Cycle of Reveals Population Heterogeneity.

Using the model host/pathogen pair /, we have shown that these bacteria could kill their insect host, survive in its cadaver and form spores by sequentially activating virulence, necrotrophism and sporulation genes. However, the population isolated from the cadavers was heterogeneous, including non-sporulating cells in an unknown physiological state. To characterize these bacteria, we used a transcriptional fusion between the promoter of a gene expressed during early exponential growth () and a reporter gene encoding a destabilized version of GFP, in combination with a fluorescent reporter of the necrotrophic state.

The impact of sewage sludge and compost on winter triticale.

There is an increasing interest in the agricultural application of organic waste such as soil amendment, due to the possibility of recycling valuable components, organic matter, and nutrient elements necessary for plant growth. The present study was carried out to evaluate the effects of sewage sludge, and green waste compost application, on a forage crop, triticale "X Triticosecale Wittmack" compared to unfertilized control. The experimental design was installed in the glasshouse conditions at the Regional Field Crop Research Center in Beja, Tunisia.